Enwere ike iji nri ketogenic dị ka ọgwụgwọ dị irè maka ịṅụbiga mmanya ókè?

Otu RCT nke izu 3 mere site na National Institute of Alcohol Abuse and Alcoholism chọpụtara na nri ketogenic nwere ike ibelata mkpa ọgwụ detox, belata mgbaàmà ịṅụ mmanya na-aba n'anya, ma belata agụụ mmanya. Ndị nyocha ahụ chọpụtakwara na nyocha ụbụrụ nke ndị sonyere na-eji nri ketogenic belatara mbufụt ma nwee mgbanwe dị mma na metabolism ụbụrụ.

Okwu Mmalite

Na blọọgụ a, abụ m ọ bụghị na-aga ịkọwapụta mgbaàmà ma ọ bụ ọnụ ọgụgụ nke ịṅụbiga mmanya ókè na-adịghị ala ala. Emebere akwụkwọ ozi a ka ọ bụrụ nyocha ma ọ bụ mmụta n'ụzọ ahụ. Ihe m ga - eme bụ ịgwa gị gbasara ihe ọmụmụ nke ọma nke ọma, nke dị elu site na iji nri ketogenic dị ka ọgwụgwọ maka ịṅụbiga mmanya ókè. Anyị ga-atụlekwa ihe usoro ọgwụgwọ na-eji nri ketogenic nwere ike ịdabere n'ihe dị adị na akwụkwọ nyocha.

Nri ketogenic na-agwọ mgbaàmà mwepu mmanya n'ime mmadụ

The National Institute of Alcohol Abuse and Alcoholism mere a 3-izu ọmụmụ inpatient nke ala ala ndị aṅụrụma. A nabatara ndị sonyere na ngalaba ụlọ ọgwụ wee wepụsịa ya. E kenyere ha na-enweghị usoro ma ọ bụ nri ndị America ma ọ bụ nri ketogenic iji hụ ma ọ nwere ike ime mgbanwe.

Ha chọpụtara na ndị nwetara nri keto chọrọ obere ọgwụ detox (dịka ọmụmaatụ, benzodiazepines), akara ngosi mmịnye mmanya na-adị ole na ole, agụụ mmanya na-aba n'anya, na nyocha ụbụrụ ha gosipụtara mbelata mbufụt na mgbanwe nke ụbụrụ metabolism. (Ị nwere ike ịgụ ihe ọmụmụ ahụ Ebe a.)

Dị ka a ga - asị na nsonaazụ ndị ahụ ezughị oke, enwere ogwe aka anụmanụ nke nyocha nke gosipụtara na oke nyere nri ketogenic belatara ịṅụ mmanya.

Ndị mmadụ na-enwe mgbagwoju anya banyere otu nri ketogenic nwere ike isi nyere ndị aṅụrụma na-adịghị ala ala (hardcore), ndị na-enweghị ike ịkwụsị ịṅụ mmanya, na-emebi ndụ ha, mmekọrịta, na ahụ ha. Kedu ka enyemaka nri dị ka nri ketogenic ga-esi nyere aka na ogo a?

Kedu ihe ụfọdụ n'ime usoro ọgwụgwọ dị n'okpuru nwere ike ịbụ?

Ka anyị tinye ụfọdụ n'ime ihe anyị maralarị gbasara ka nri ketogenic nwere ike isi nyere aka gwọọ ọrịa uche site na blọgụ blọgụ mbụ.

Kedu ihe ndị neurobiological anyị na-ahụ na ịṅụbiga mmanya ókè?

Na aga post, anyị tụlere usoro nke nri ketogenic nwere ike gbanwee mgbaàmà nke nchekasị. N'akwụkwọ ọzọ, anyị tụlere ka ọ ga-esi gwọọ ịda mbà n'obi. Na post a, anyị ga-ahụ ma a na-ahụ akụkụ anọ nke pathology na mmanya mmanya:

  • Hypometabolism nke glucose
  • Mmetụta neurotransmitter
  • mbufụt
  • oxidative nchegbu

Alcoholism na glucose hypometabolism

Glucose hypometabolism eguzobewo nke ọma dị ka usoro ọrịa na-egbu egbu na mmanya. Anyị na-ahụ hypometabolism na fronto-cerebellar sekit na Ọrụ sekit Papez na n'azụ azụ, premotor, na parietal cortices. Mgbe ụbụrụ enweghị ike iji mmanụ ọkụ nke ọma, anyị ga-ahụkarị mbelata n'ụdị ụbụrụ. Mbelata n'ụdị ụbụrụ bụ ihe si na hypometabolism ụbụrụ na-adịte aka. N'ime ụbụrụ aṅụrụma, anyị na-ahụ mbelata siri ike n'ụdị ụbụrụ ndị a:

  • cerebellum (nguzozi, ọnọdụ, mmụta moto, mmegharị ahụ)
  • cingulate cortex (nchịkwa nchịkwa, ebe nchekwa na-arụ ọrụ, na mmụta; njikọ njikọ nke mmetụta uche, mmetụta na omume)
  • thalamus (ọtụtụ ọrụ, gụnyere Circadian rhythms)
  • hippocampus (ncheta)

Mgbe mmadụ bụ onye aṅụrụma na-adịghị ala ala, isi iyi mmanụ ụbụrụ ha na-esi n'iji glucose eme ihe dị ka mmanụ ọkụ gaa n'ihe a na-akpọ acetate.

A mara na isi iyi nke acetate n'ime ahụ sitere na nbibi nke mmanya na-aba n'anya na imeju, nke na-eduga n'ịba ụba acetate ọbara ngwa ngwa.

https://www.news-medical.net/news/20191024/Acetate-derived-from-alcohol-metabolism-directly-influences-epigenetic-regulation-in-the-brain.aspx

Kedu ka nri ketogenic ga-esi agwọ hypometabolism glucose na mmanya na-adịghị ala ala?

A naghị eme acetate naanị site na mmanya na-agbaji na imeju. Ọ bụkwa otu n'ime ahụ ketone atọ a na-eme na ketosis. Ya mere, maka ụbụrụ aṅụrụma, nke nwere nnukwu glucose hypometabolism na nke na-adabere na acetate maka mmanụ ụgbọala, ọ bụ ihe ezi uche dị na ya na nri ketogenic nwere ike inye nnapụta ike maka hypometabolism anyị na-ahụ na ndị a.

Anyị chere na mgbanwe mberede na-etolite ụbụrụ na-eri ahụ ketone, nke na-eme na mmanya mmanya na-aba n'anya (AUD) dị ka mgbanwe maka ịṅụ mmanya na-aba n'anya ugboro ugboro, iji glucose dị ka isi iyi ike, nke na-emeghachi na nsị, nwere ike itinye aka na mmanya na-aba n'anya. mwepụ ọrịa.

https://www.science.org/doi/abs/10.1126/sciadv.abf6780

N'ikwu ya n'ụzọ ọzọ, ọ bụrụ na ụbụrụ gị na-eji otu mmanụ ọkụ (acetate) wee wepụ kpamkpam isi mmanụ mmanụ ya masịrị ya, ọ bụ ihe ezi uche dị na ya na ọchịchọ gị maka mmanụ ahụ ga-abawanye. Na nsogbu ike ga-eme na ụbụrụ. Ma ọ bụrụ na ị dochie mmanụ ụgbọala ahụ n'ụzọ ọzọ, nke na-adịghị ebibi ahụ gị na ụbụrụ gị, site na nri ketogenic, ụbụrụ gị na-enweta mmanụ ọkụ mgbe ahụ na ụbụrụ gị na-arụ ọrụ siri ike nke ọgwụgwọ. Na n'ikpeazụ, ka ahụ ike metabolic nke ụbụrụ na ahụ gị na-akawanye mma, ụbụrụ gị nwere ike iji glucose nke ọma dị ka mkpụrụ. Mana ruo mgbe nke ahụ mere, ịchọrọ mmanụ mgbapụta yiri ya. Na nri ketogenic na-enye nke ahụ.

Alcoholism na Neurotransmitter adịghị mma

Ụfọdụ n'ime adịghị mma nke neurotransmitter a na-ahụ na ịṅụbiga mmanya ókè gụnyere dopamine, serotonin, glutamate, na GABA.

Dopamine na-akwalite mkpali anyị ma nwee ọrụ dị mkpa na ụlọ ọrụ ụgwọ ọrụ anyị. A na-ahụta ya dị ka onye na-ekere òkè na ịṅụbiga mmanya ókè ma na-abawanye nanị na atụmanya nke ịṅụ mmanya. Mgbe ndị mmadụ na-ewepụ mmanya na-aba n'anya, a na-ebelata ọrụ dopamine, nke nwere ike itinye aka na mgbaàmà nkwụsị na ịlaghachi azụ mmanya.

A na-ahụta ụbụrụ ndị aṅụrụma ka ọ na-agwụ na serotonin, a na-eche na nke a na-enye aka na omume gburugburu enweghị mmasị na ịṅụ mmanya.

Ịṅụ mmanya na-aba n'anya na-abawanye ọrụ GABA. GABA bụ neurotransmitter inhibitory nke anyị na-achọkarị ntakịrị karịa n'ihi na ọ na-eme ka anyị nwee ahụ iru ala. Ma na ụbụrụ aṅụrụma, ka ha na-aga site na nkwụsị, GABA na-agbadata, nke pụtara na ị nweghị ike imezu ya.

A na-agbanwe usoro GABA na ụbụrụ n'ọnọdụ mmanya na-adịghị ala ala. Dịka ọmụmaatụ, n'akụkụ ụfọdụ nke ụbụrụ, okwu nke mkpụrụ ndụ ihe nketa nke na-etinye ihe ndị na-anabata GABAA na-emetụta n'ihi mmanya.

Banerjee, N. (2014). Neurotransmitters na mmanya na-egbu egbu: nyocha nke neurobiological na mkpụrụ ndụ ihe nketa. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4065474/

Ndị nnata ahụ anaghị arụ ọrụ site na ịṅụ mmanya na-adịghị ala ala. Nke a bụ ya mere anyị na-enyekarị benzodiazepines iji nyere aka na ndọrọ ego na ndị mmadụ na-anwa ịzere. Ọ bụ mbọ iji dozie ahaghị nhata nke neurotransmitter nke na-abịa site na mwepụ.

N'aka nke ọzọ, a na-ebelata glutamate n'oge ịṅụ mmanya. Na posts ndị ọzọ na nsogbu ndị ọzọ, karịsịa nsogbu nchekasị, anyị na-ahụ glutamate na-achịkwa steeti neurotransmitter. Nke a nwere ike ịbụ ihe kpatara na ọtụtụ mmadụ na-eji mmanya na-aba n'anya na-aṅụ ọgwụ onwe ha (dịka ọmụmaatụ, nchegbu ọha mmadụ). N'ime ụbụrụ aṅụrụma, a na-eche na glutamate na-enye aka na nhazigharị nke ụbụrụ nke na-emepụta hyperexcitability na agụụ n'oge ịṅụ mmanya na-aba n'anya.

Kedu ka nri ketogenic ga-esi nyere aka na-agwọ adịghị mma nke neurotransmitter hụrụ na mmanya na-adịghị ala ala?

Nri ketogenic na-achịkwa mmepụta nke ọtụtụ neurotransmitters maka ụbụrụ aṅụrụma na-aga site na mwepụ. E gosipụtara nri ketogenic iji mee ka mmepụta serotonin dịkwuo elu, mụbaa GABA, nguzozi glutamate na ọkwa dopamine.

Otu n'ime ụzọ a na-esi eme nke a bụ site na mbelata mbufụt, nke anyị ga-atụle na ngalaba na-esote. Mgbe ụbụrụ na-ata ahụhụ site na neuroinflammation (spoiler: ụbụrụ aṅụrụma n'ezie nwere mbufụt) ọ na-akpaghasị nguzozi na ọrụ nke neurotransmitters. Ụzọ ọzọ aṅụrụma na-adịghị ala ala nwere ike imebi nguzozi nke neurotransmitter bụ site na erighị ihe na-edozi ahụ. Vitamin B, magnesium, na ọtụtụ ndị ọzọ dị mkpa micronutrient cofactors na-agwụcha na ọ dịghị mfe eweghachi. Ndị na-aṅụ mmanya na-aba n'anya nwere ike ọ gaghị ebute ụzọ maka nri dị mma, ọ bụrụgodị na ha emee, enwere mgbanwe na-eme na eriri afọ microbiome nke nwere ike ibelata absorption nke vitamin na mineral ndị dị mkpa. Enweghị oriri amino acid na-esite na ịhọrọ mmanya na-edozi ahụ nwere ike imebi ikike ụbụrụ ịmepụta neurotransmitters ma mepụta enzymes na-achịkwa ọrụ neurotransmitter.

Alcoholism na Neuroinflammation

Neuroinflammation na-eme mgbe enwere mwakpo na neurons. Nke a nwere ike ịbụ site na mmerụ ahụ nke isi, ihe ndị na-esi na mgbochi ụbụrụ ụbụrụ na-agbapụta, ma ọ bụ ịṅụ mmanya na-adịghị ala ala. Ọrịa a, mgbe ọ na-apụ apụ, ga-ebute ọnwụ nke mkpụrụ ndụ, na-adịkarị n'akụkụ ibe ya. Selụ ndị a zaa aza ma igwe n'ime ha na-akụrisị. N'ikpeazụ, mkpụrụ ndụ ndị a na-emebi emebi na-enweghị atụ site na mbufụt, ga-agbawa ma kwafuo ihe mkpofu ebe ha na-abụghị. Nke a abụghị usoro ọnwụ cell nkịtị ma ọ bụ ahụike. Ya mere, irighiri ihe ga-eduga na usoro mkpali mpaghara ka ahụ na-anwa ikpochapụ ọgbaghara ahụ.

Enwere mmetụta kpọmkwem nke mmanya (aka ethanol) nwere na ụbụrụ nke na-ebute neuroinflammation.

Nzaghachi usoro neuroimmune maka oriri ethanol, na mpaghara ụbụrụ ụfọdụ dị ka amygdala, hippocampus na frontal cortex [na ​​ụmụ oke], na-etinye aka na riri ahụ na ụkọ omume a na-ahụ na ịṅụbiga mmanya ókè.

Haorah, J., Knipe, B., Leibhart, J., Ghorpade, A., & Persidsky, Y. (2005). Nchegbu oxidative kpatara mmanya na-akpata na mkpụrụ ndụ endothelial ụbụrụ na-akpata arụrụ ọrụ mgbochi ụbụrụ ọbara. http://dx.doi.org/10.14748/bmr.v28.4451.

Neurodegeneration hụrụ na ịṅụbiga mmanya ókè na-adịghị ala ala sitere na neuroinflammation na-adịghị ala ala. Nzaghachi neuroinflammatory a bụ n'ihi akara nke mkpụrụ ndụ glial (TLR4) bụ ndị na-ebute ụdị ọnwụ cell a.

Kedu ka nri ketogenic si ebelata neuroinflammation na ndị nwere mmanya na-adịghị ala ala?

E gosipụtara nri ketogenic iji belata cytokines TLR4 kpọmkwem, yana ịhazi usoro mkpali. Ọ na-eme nke a site n'ịbụ molekul na-egosi nke nwere ike ịgbanwuo ma gbanyụọ mkpụrụ ndụ ihe nketa iji dozie mbufụt. Nke a na-eme ka mbufụt na-agbada. Na ụbụrụ nke kpugheere mmanya na-adịghị ala ala bụ nke na-agba ọkụ.

Nri ketogenic nwere ike inye aka belata mbufụt a ngwa ngwa, na-eme ka ụbụrụ nwee ike ịrụzi, weghachi na ịgwọ ọrịa. Dị ka anyị mụtara na ngalaba nguzozi nke neurotransmitter, mbufụt ga-agbadarịrị ka e wee mee ka ndị na-ahụ maka neurotransmitters dị n'ụdị kwesịrị ekwesị na nguzozi.

Akpụkpọ anụ Neuronal, nke bụ akụkụ dị mkpa nke mkpụrụ ndụ ụbụrụ, enweghị ike ịrụ ọrụ nke ọma ma ọ bụrụ na ha fụrụ akpụ ma na-emeso ọnwụ cell na-abịanụ. Iweda mbufụt site na enyemaka dị ike na-egbochi mkpali, dị ka nri ketogenic, nwere ike ịba uru naanị. Ndị sonyere n'ọmụmụ ihe ahụ nwere obere mbufụt karịa ndị na-ahụ maka njikwa yana mbelata nke mbufụt nwere ike ịbụ ihe nyeere ndị sonyere ọmụmụ ihe aka inweta nsonaazụ dị mma ka ha na-agabiga mmanya ókè.

Mmanya na-egbu egbu na nrụgide Oxidative

Ọkwa siri ike nke nrụgide oxidative na-eme na ịṅụbiga mmanya ókè. Nchegbu oxidative na-ezo aka n'ibu arọ nke na-eme mgbe ike anụ ahụ nwere ime ihe banyere ụdị oxygen na-emeghachi omume (ROS) enweghị nguzozi. Ndị na-adịghị aṅụ mmanya na-emepụta ụfọdụ ụdị oxygen na-emeghachi omume nanị iku ume na ịmepụta ume na ịdị ndụ. Mana n'ime ndị ahụ siri ike, a na-edozi ibu ROS a nke ọma na ọ dịghị ka ọ na-enye aka na steeti ọrịa nnukwu (ọ bụ ezie na anyị ka na-aka nká, ọ dị mwute ikwu). Dị ka ị nwere ike iche n'echiche, aṅụrụma na-adịghị ala ala na-atụ aro nguzozi a n'ụzọ na ROS na-abawanye.

Obere nrụgide oxidative ga-adị mma nye onye ọ bụla, mana ọ dị mma karịsịa maka ndị aṅụrụma. Gịnị kpatara? N'ihi na mmanya na-aba n'anya na-akasị mma na-emebi ihe mgbochi ụbụrụ-ọbara.

Ya mere, nrụgide oxidative nke sitere na metabolism mmanya na ụbụrụ microvascular endothelial cell nwere ike iduga nkwụsị nke ụbụrụ ụbụrụ na ịṅụbiga mmanya ókè, na-eje ozi dị ka ihe na-eme ka ọ dịkwuo njọ na ọrịa neuroinflammatory.

Abbott, NJ, Patabendige, AA, Dolman, DE, Yusof, SR, & Begley, DJ (2010). Nhazi na ọrụ nke mgbochi ụbụrụ ọbara.  https://doi.org/10.1189/jlb.0605340

Na na mgbochi ọbara-ụbụrụ dị oke mkpa maka ịrụ ọrụ ụbụrụ dị mma. Ọ bụ nchebe site na mwakpo nke ụbụrụ na-adabere na ya, na mgbe njikọ ndị ahụ siri ike na-atọpụ ma hapụ ihe ndị ahụ na-agaghị adị, ọ na-ebute nzaghachi neuroinflammatory dị ize ndụ. Nzaghachi neuroinflammatory na-adịghị akwụsị akwụsị na-ebelata nri na-edozi ahụ na-agbalị ịlụso ha ọgụ, na-afụ mkpụrụ ndụ, ma mee ka cytokines na-egbuke egbuke na-amụba mbufụt. Ka ụdị oxygen na-emeghachi omume na-arị elu ike ahụ ijikwa ya na-agbada, na-ebute mmụba nke nrụgide oxidative.

Ndị na-aṅụ mmanya na-aba n'anya nwere ọtụtụ nrụgide oxidative na-eme na ụbụrụ, ma ha nwekwara ya na ahụ ha. A na-ahụ ọrịa imeju na-egbu egbu na-aba n'anya, usoro ọrịa na-agbawa obi nke na-eme na ịṅụbiga mmanya ókè na-adịghị ala ala, ka a na-ahụ ka ọ na-emepụta nnukwu nrụgide oxidative.

Ọgwụ ethanol siri ike na nke na-adịghị ala ala na-abawanye mmepụta nke ROS, na-ebelata ọkwa antioxidant cell, ma na-akwalite nrụgide oxidative n'ọtụtụ anụ ahụ, karịsịa imeju.

Wu, D., & Cederbaum, AI (2009, Mee). Oxidative nchekasị na ọrịa imeju aṅụrụma. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0029-1214370

Kedu ka nri ketogenic ga-esi belata nrụgide oxidative na ndị nwere mmanya?

Nri ketogenic na-ebelata nchekasị oxidative n'ọtụtụ ụzọ, ụfọdụ n'ime ha anyị tụlere na ngalaba ndị gara aga. Cytokines nke na-akpasu iwe na-ebute mbelata mbufụt ma mepụta ụdị ikuku oxygen na-adịghị arụ ọrụ ka ọ bụrụ nke a ga-ewepụ. Otu n'ime ụzọ o si eme ya bụ imeziwanye (ime ka karịa) ihe na-egbochi oxidant nke a na-akpọ glutathione. Nke a bụ ihe mgbochi antioxidant siri ike nke ị na-enweta karịa na nri ketogenic.

Egosiputara metabolism nke ketones nke cerebral iji meziwanye ike cellular, na-abawanye ọrụ glutathione peroxidase, belata ọnwụ cell ma nwee ikike mgbochi mkpali na antioxidant na ha abụọ. in vitro na in vivo ụdị.

Greco, T., Glenn, TC, Hovda, DA, & Prins, ML (2016). Nri ketogenic na-ebelata nrụgide oxidative ma kwalite ọrụ mgbagwoju anya nke mitochondrial. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5012517/

Ketones na-eme nke a site n'ịbawanye ihe mkpụrụ ndụ chọrọ n'ezie na nke nwere ike ibelata na ọrịa na-adịghị ala ala dị ka ịṅụbiga mmanya ókè. Ihe dị mkpa a na-akpọ nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) ma ị nwere ike iche banyere ya dị ka ihe na-emekọ ihe, nke pụtara na mkpụrụ ndụ chọrọ ya iji mee ihe. Ihe ndị ọzọ na-emekọ ihe na-enyere ahụ gị aka iji enzymes rụọ ọrụ antioxidants dị ike n'ime ahụ gị, dị ka glutathione.

Ụzọ ndị ọzọ nri ketogenic na-esi eme ka nrụgide oxidative dịkwuo mma bụ ọrụ akpụkpọ anụ cell na-emeziwanye nke anyị tụlere. Ọrụ akpụkpọ ahụ cell a na-eme ka ọ dịkwuo mma na-eduga n'ịhazi synaptic ka mma, na-emepụta nhazi nke neurotransmitter ka mma. Mmụba nke mitochondria, ụlọ ọrụ ike nke mkpụrụ ndụ neuronal, na-enye cell ahụ ike karịa maka nrịbama cell ka mma na ike zuru oke iji hichaa na idobe sel na akụkụ ya niile.

mmechi

Nri ketogenic abụghị naanị usoro ọgwụgwọ maka nsogbu ịṅụ mmanya na-aba n'anya. Ọ bụ olile anya m na ndị mmadụ ga-eji usoro nri a siri ike na nri enyere ha aka na njem mgbake ha. Karịsịa na ndị gbalịsiri ike ma ọ bụ daa n'oge gara aga na-eji usoro ọgwụgwọ dị ugbu a.

Site n'enyemaka nke nbibi nke ọgwụ na-ahụ maka ahụike, nri ketogenic na-agwọ aṅụrụma ma eleghị anya, dị ka akụkụ ọmụmụ anụmanụ nke nyocha a, na-enyere aka melite ohere nke nlọghachi azụ.

Achọrọ m ịgba gị ume ka ị mụtakwuo gbasara nhọrọ ọgwụgwọ gị site na nke ọ bụla n'ime ihe ndị a blog posts. Ana m ede maka usoro dị iche iche n'ọkwa dị iche iche nke nkọwa nke ị nwere ike ịhụ na ọ na-enyere gị aka ịmụta na njem ahụike gị. Ị nwere ike ịnụ ụtọ ya Ọmụmụ ihe gbasara Ketogenic ibe iji mụta ka ndị ọzọ siri jiri nri ketogenic agwọ ọrịa uche na omume m. Ma ị nwere ike irite uru na nghọta ka iso onye ndụmọdụ ahụike uche na-arụ ọrụ mgbe ị na-atụgharị na nri ketogenic nwere ike inye aka ebe a.

Kekọrịta ozi blọgụ a ma ọ bụ ndị ọzọ gị na ndị enyi na ezinụlọ na-arịa ọrịa uche. Mee ka ndị mmadụ mara na olileanya dị.

Ị nwere ike ịmụtakwu gbasara m Ebe a. Ọ bụrụ na ị ga-achọ ịkpọtụrụ m ị nwere ike ime ya Ebe a. Ọ bụ ihe ùgwù m ịgwa gị ụzọ niile dị iche iche ị ga-esi na-adị gị mma.

Dị ka ihe ị na-agụ na blọgụ? Chọrọ ịmụta maka webinars na-abịa, nkuzi na ọbụna na-enye nkwado na iso m na-arụkọ ọrụ maka ebumnuche ọdịmma gị? debanye aha!


References

Acetate sitere na mmanya na-aba n'anya metabolism na-emetụta usoro epigenetic ozugbo na ụbụrụ. (Ọktoba 2019, 24). Akụkọ-Medical.Net. https://www.news-medical.net/news/20191024/Acetate-derived-from-alcohol-metabolism-directly-influences-epigenetic-regulation-in-the-brain.aspx

Banerjee, N. (2014). Neurotransmitters na mmanya na-egbu egbu: nyocha nke neurobiological na mkpụrụ ndụ ihe nketa. Akwụkwọ akụkọ India nke Human Genetics, 20(1), 20. https://doi.org/10.4103/0971-6866.132750

Castro, AI, Gomez-Arbelaez, D., Crujeiras, AB, Granero, R., Aguera, Z., Jimenez-Murcia, S., Sajoux, I., Lopez-Jaramillo, P., Fernandez-Aranda, F. , & Casanueva, FF (2018). Mmetụta nke nri Ketogenic dị obere kalori na agụụ nri na mmanya na-aba n'anya, omume anụ ahụ na nke mmekọahụ, nsogbu ụra, na ogo ndụ na ndị ọrịa buru ibu. Nri, 10(10), 1348. https://doi.org/10.3390/nu10101348

Cingulate Cortex—Nlebanya | Isiokwu ScienceDirect. (nd). Eweghachitere Disemba 31, 2021, site na https://www.sciencedirect.com/topics/neuroscience/cingulate-cortex

Da Eira, D., Jani, S., & Ceddia, RB (2021). Obesogenic na nri ketogenic na-achịkwa nke ọma SARS-CoV-2 protein ntinye ACE2 na TMPRSS2 na sistemu Renin-Angiotensin na akwara oke na akwara obi. Nri, 13(10), 3357. https://doi.org/10.3390/nu13103357

Dahlin, M., Elfving, A., Ungerstedt, U., & Amark, P. (2005). Nri ketogenic na-emetụta ọkwa nke amino acids excitatory na inhibitory na CSF n'ime ụmụaka nwere Akwụkwụ na-atụgharị. Nnyocha Akwụkwụ na-adọ, 64(3), 115-125. https://doi.org/10.1016/j.eplepsyres.2005.03.008

de la Monte, SM, & Kril, JJ (2014). Neuropathy metụtara mmanya mmadụ. Ọrụ Neuropathologica, 127(1), 71-90. https://doi.org/10.1007/s00401-013-1233-3

Dencker, D., Molander, A., Thomsen, M., Schlumberger, C., Wortwein, G., Weikop, P., Benveniste, H., Volkow, ND, & Fink-Jensen, A. (2018). Nri Ketogenic na-egbochi ọrịa ịwepu mmanya na-aba n'anya na oke. Alcoholism: Nnyocha Nlekọta Ọgwụ na Ule, 42(2), 270-277. https://doi.org/10.1111/acer.13560

Dowis, K., & Banga, S. (2021). Uru ahụike enwere ike nke nri Ketogenic: Nyochaa Akụkọ. Nri, 13(5). https://doi.org/10.3390/nu13051654

Ubi, R., Ubi, T., Pourkazemi, F., & Rooney, K. (2021). Nri ketogenic na sistem ụjọ: nyocha nyocha nke nsonaazụ akwara sitere na ketosis nri na ọmụmụ anụmanụ. Nyocha nyocha ihe oriri, 1-14. https://doi.org/10.1017/S0954422421000214

Gano, LB, Patel, M., & Rho, JM (2014). Nri ketogenic, mitochondria, na ọrịa akwara ozi. Akwụkwọ akụkọ nke Lipid Research, 55(11), 2211-2228. https://doi.org/10.1194/jlr.R048975

Greco, T., Glenn, TC, Hovda, DA, & Prins, ML (2016). Nri ketogenic na-ebelata nrụgide oxidative ma kwalite ọrụ mgbagwoju anya nke mitochondrial. Akwụkwọ nke Ọrịa Ọbara Ọkụ & Metabolism, 36(9), 1603. https://doi.org/10.1177/0271678X15610584

Haorah, J., Knipe, B., Leibhart, J., Ghorpade, A., & Persidsky, Y. (2005). Nchegbu oxidative na-akpata mmanya na-akpata na mkpụrụ ndụ endothelial ụbụrụ na-akpata arụrụ ọrụ mgbochi ụbụrụ ọbara. Akwụkwọ akụkọ Leukocyte Biology, 78(6), 1223-1232. https://doi.org/10.1189/jlb.0605340

Jumah, FR, & Dossani, RH (2021). Neuroanatomy, Cingulate Cortex. N'ime StatPearls. Mbipụta StatPearls. http://www.ncbi.nlm.nih.gov/books/NBK537077/

Koh, S., Dupuis, N., & Auvin, S. (2020). Ketogenic nri na Neuroinflammation. Nnyocha Akwụkwụ na-adọ, 167, 106454. https://doi.org/10.1016/j.eplepsyres.2020.106454

Loguercio, C., & Federico, A. (2003). Oxidative nchekasị na viral na mmanya ịba ọcha n'anya. Biology na Medicine Free Radical, 34(1), 1-10. https://doi.org/10.1016/S0891-5849(02)01167-X

Masino, SA, & Rho, JM (2012). Usoro nke Ketogenic Diet Action. Na JL Noebels, M. Avoli, MA Rogawski, RW Olsen, & AV Delgado-Escueta (Eds.), Usoro ntọala nke Jasper nke Epilepsy (edemede nke anọ). National Center for Biotechnology Information (US). http://www.ncbi.nlm.nih.gov/books/NBK98219/

Morris, A.A. M. (2005). Cerebral ketone metabolism. Akwụkwọ nke Ọrịa Metabolic Nketa, 28(2), 109-121. https://doi.org/10.1007/s10545-005-5518-0

Newman, JC, & Verdin, E. (2017). β-Hydroxybutyrate: Metabolite na-egosi. Nlebanya nke nri kwa afọ, 37, 51. https://doi.org/10.1146/annurev-nutr-071816-064916

Norwitz, NG, Dalai, Sethi, & Palmer, CM (2020). Nri ketogenic dị ka ọgwụgwọ metabolic maka ọrịa uche. Echiche dị ugbu a na Endocrinology, ọrịa shuga na oke ibu, 27(5), 269-274. https://doi.org/10.1097/MED.0000000000000564

Rehm, J., & Imtiaz, S. (2016). Nyochaa akụkọ banyere ịṅụ mmanya na-aba n'anya dị ka ihe ize ndụ maka ibu ọrịa zuru ụwa ọnụ. Ọgwụgwọ, Mgbochi, na Iwu Mmejọ Ihe, 11(1), 37. https://doi.org/10.1186/s13011-016-0081-2

Rheims, S., Holmgren, CD, Chazal, G., Mulder, J., Harkany, T., Zilberter, T., & Zilberter, Y. (2009). Omume GABA na akwara neocortical neocortical akabeghị aka na-adabere na nnweta ahụ ketone. Akwụkwọ Neurochemistry, 110(4), 1330-1338. https://doi.org/10.1111/j.1471-4159.2009.06230.x

Ritz, L., Segobin, S., Lannuzel, C., Boudehent, C., Vabret, F., Eustache, F., Beaunieux, H., & Pitel, AL (2016). ntụnyere voxel kpọmkwem n'etiti ihe isi awọ na-ebelata na hypometabolism glucose na mmanya na-adịghị ala ala. Akwụkwọ nke Cerebral Blood Flow and Metabolism: Akwụkwọ edemede nke International Society of Cerebral Blood Flow and Metabolism, 36(9), 1625-1640. https://doi.org/10.1177/0271678X15611136

Rothman, DL, De Feyter, HM, de Graaf, RA, Mason, GF, & Behar, KL (2011). 13C MRS ọmụmụ nke neuroenergetics na neurotransmitter ịgba ígwè na ụmụ mmadụ. NMR na Biomedicine, 24(8), 943-957. https://doi.org/10.1002/nbm.1772

Shimazu, T., Hirschey, MD, Newman, J., He, W., Shirakawa, K., Moan, NL, Grueter, CA, Lim, H., Saunders, LR, Stevens, RD, Newgard, CB, Farese , RV, Jr, Cabo, R. de, Ulrich, S., Akassoglou, K., & Verdin, E. (2013). Mgbochi nke nrụgide Oxidative site na β-Hydroxybutyrate, ihe mgbochi Histone Deacetylase. Sayensị (New York, NY), 339(6116), 211. https://doi.org/10.1126/science.1227166

Sullivan, EV, & Zahr, NM (2008). Neuroinflammation dị ka usoro neurotoxic na mmanya na-egbu egbu: nkọwa na "MCP-1 na-abawanye na microglia na mpaghara dị iche iche nke ụbụrụ aṅụrụma mmadụ." Neurology nnwale, 213(1), 10-17. https://doi.org/10.1016/j.expneurol.2008.05.016

Tabakoff, B., & Hoffman, PL (2013). Neurobiology nke ịṅụ mmanya na-aba n'anya na ịṅụbiga mmanya ókè: akụkọ ihe mere eme. Usoro ọgwụ na ọgwụ nje na ọgwụ, 113, 20-37. https://doi.org/10.1016/j.pbb.2013.10.009

Tomasi, DG, Wiers, CE, Shokri-Kojori, E., Zehra, A., Ramirez, V., Freeman, C., Burns, J., Kure Liu, C., Manza, P., Kim, SW, Wang, G.-J., & Volkow, ND (2019). Njikọ n'etiti Mbelata Glucose Metabolism Brain na Cortical Ọkpụrụkpụ na Mmanya: Ihe akaebe nke Neurotoxicity. International Journal of Neuropsychopharmacology, 22(9), 548-559. https://doi.org/10.1093/ijnp/pyz036

Volkow, ND, Wiers, CE, Shokri-Kojori, E., Tomasi, D., Wang, G.-J., & Baler, R. (2017). Neurochemical na metabolic mmetụta nke nnukwu mmanya na-adịghị ala ala na ụbụrụ mmadụ: Ọmụmụ ihe na positron emission tomography. Neuropharmacology, 122, 175-188. https://doi.org/10.1016/j.neuropharm.2017.01.012

Wiers, CE, Vendruscolo, LF, Veen, J.-W. van der, Manza, P., Shokri-Kojori, E., Kroll, DS, Feldman, DE, McPherson, KL, Biesecker, CL, Zhang, R., Herman, K., Elvig, SK, Vendruscolo, JCM, Turner , SA, Yang, S., Schwandt, M., Tomasi, D., Cervenka, MC, Fink-Jensen, A., … Volkow, ND (2021). Nri ketogenic na-ebelata akara ngosi mmịnye mmanya n'ime mmadụ yana ịṅụ mmanya na-aba n'anya na òké. Ọganihu Sayensị. https://doi.org/10.1126/sciadv.abf6780

Wu, D., & Cederbaum, AI (2009). Nchegbu Oxidative na Ọrịa imeju na-egbu egbu. Ọmụmụ ihe na ọrịa imeju, 29(2), 141-154. https://doi.org/10.1055/s-0029-1214370

Yamanashi, T., Iwata, M., Kamiya, N., Tsunetomi, K., Kajitani, N., Wada, N., Iitsuka, T., Yamauchi, T., Miura, A., Pu, S., Shirayama, Y., Watanabe, K., Duman, RS, & Kaneko, K. (2017). Beta-hydroxybutyrate, onye na-eme ihe na-eme ka ọ bụrụ ihe na-adịghị mma nke NLRP3 endogenic, na-eme ka mmeghachi omume na-akpata nchekasị na-akpata. Akụkọ sayensị, 7(1), 7677. https://doi.org/10.1038/s41598-017-08055-1

Zehra, A., Lindgren, E., Wiers, CE, Freeman, C., Miller, G., Ramirez, V., Shokri-Kojori, E., Wang, G.-J., Talagala, L., Tomasi , D., & Volkow, ND (2019). Njikọ akwara nke anya na nsogbu ịṅụ mmanya na-aba n'anya. Ọgwụ na Alcohol aṅụrụma, 194, 430-437. https://doi.org/10.1016/j.drugalcdep.2018.10.032

Nkume a-aza

Ebe a na-eji Akismet iji belata spam. Mụta otu esi etinye usoro data gị.