Enwere ihe mejupụtara mkpụrụ ndụ ihe nketa na ọrịa bipolar?

N'ezie, enwere ihe mejupụtara mkpụrụ ndụ ihe nketa na ọrịa bipolar. A na-eche na ihe nketa ga-adị n'etiti 60-85%. Achọpụtala ụfọdụ mkpụrụ ndụ ihe nketa dị ka ebumnuche dị mkpa maka itinye aka na ọgwụ. Ketones bụ ndị ogbugbo na-arụsi ọrụ ike na ụfọdụ ụzọ mkpụrụ ndụ ihe nketa ndị a, ma n'okwu ma ọ bụ n'okwu n'ihu n'ihu. A na-enyocha nri ketogenic ugbu a dị ka ọgwụgwọ maka ọrịa bipolar.

Okwu Mmalite

Ọtụtụ mgbe, mgbe m na-ede banyere ọrịa uche na iji nri ketogenic dị ka ọgwụgwọ, m na-elekwasị anya na akụkụ nke glucose hypometabolism, neurotransmitter imbalances, mbufụt, na oxidative stress. Mana n'ime nyocha m maka blọgụ blọgụ na ọrịa bipolar, enwere m obi ụtọ ịhụ ọtụtụ nyocha ka a na-eme na usoro mkpụrụ ndụ ihe nketa. Ka m na-agụ site na ụfọdụ mkpụrụ ndụ ihe nketa ndị a chọpụtara, achọpụtara m ọtụtụ n'ime ha ma ọ bụ ụzọ ha na-emetụta ka ketone na-emetụta ya.

Mkpụrụ ndụ ihe nketa biochemistry abụghị ihe m ga-akpọ siri ike. Ma ekpebiri m na n'ihi na a na-achọpụta na ọrịa bipolar na nsogbu ọnọdụ uche na-esote nwere nnukwu ihe nketa, ọ nwere ike inye aka ikwu banyere ya.

Na ndabere nke ejima na ọmụmụ ezinụlọ, a na-eme atụmatụ nketa nke BD na 60-85%.

Mullins, N. et al., (2021). Ọmụmụ ihe gbasara mkpokọta genome nke ihe karịrị 40,000 ọrịa ọrịa bipolar na-enye nghọta ọhụrụ na bayoloji dị n'okpuru.
https://doi.org/10.1038/s41588-021-00857-4

Kedu ihe kpatara m ga-eji chọọ ikwu maka mmetụta mkpụrụ ndụ ihe nketa na ọrịa bipolar?

N’ihi na mgbe ụfọdụ mgbe a gwara anyị na ọrịa uche anyị sitere na mkpụrụ ndụ ihe nketa, ọ na-adị anyị ka anyị enweghị ike ịgbanwe ihe mgbaàmà. Ma ọ bụrụ na m nwere ike ime ka ị kwenye na ọ dị ihe ị nwere ike ime iji mee ka ụfọdụ mkpụrụ ndụ ihe nketa nke a na-ahụ na ọrịa ahụ na-arịa ọrịa bipolar jikọtara ya nke ukwuu, ọ nwere ike ime ka obi dịkwuo gị mma.

Amaara m na ọ bụrụ na ị nwere ọrịa bipolar ma na-agụ blọgụ a, ị nwere ike ịbụ otu n'ime ụzọ abụọ n'ụzọ atọ nke ndị na-arịa BPD bụ ndị, mgbe ha na-agwọ ọrịa, ka na-enwe mgbaàmà prodromal na ọbụna ịda mbà n'obi episodic. Ya mere, n'ihi na achọrọ m ka ị mata ụzọ niile ị ga-esi na-enwekwu obi ụtọ, m ga-agwa gị ihe m mụtara.

Ka ị na-agụ n'okpuru ebe a, buru n'uche na ụbụrụ bipolar na-agbasi mbọ ike na ọkwa dị elu nke mbufụt na nrụgide oxidative, ume ụbụrụ (glucose hypometabolism), na nkwụsị nke neurotransmitter. Nke a ga-enyere gị aka ịghọta otú nri ketogenic na mmetụta ya na akara ngosi mkpụrụ ndụ ihe nketa na mmetụta bara uru nke ala nwere ike inye nhọrọ ọgwụgwọ dị irè.

Genes, ketones na ọrịa bipolar

Ọ bụ nnukwu mmasị ịmara, na a na-achọta mkpụrụ ndụ ihe nketa metụtara BPD ma chọpụta oge niile. Anọ n'ime ebumnuche kachasị mma maka mmepe ọgwụ ọhụrụ maka BPD na-emetụta β-Hydroxybutyrate ma ọ bụ ahụ ketone ndị ọzọ. Ma ọ na-eme na a na-emepụta ketones dịka akụkụ nke nri ketogenic. Nnyocha nke akwụkwọ ndị ahụ gosiri na mmetụta ndị ahụ bụ kpọmkwem ma ọ bụ nke dị n'okpuru na-emetụta usoro yiri ya nke a na-ahụ na pathology nke ọrịa bipolar. Ndị a gụnyere GRIN2A, CACNA1C, SCN2A, na HDAC5.

HDAC5

β-Hydroxybutyrate, ahụ ketone, na-ebelata mmetụta cytotoxic nke cisplatin site na ịgbalite HDAC5. Egosiputa mgbochi nke HDAC5 ka ọ bụrụ neuroprotective site na igbochi ụzọ apoptosis. Kedu ihe kpatara ketones agaghị enyere aka n'ịgwọ ụdị mkpụrụ ndụ ihe nketa nke HDAC5 site na ịkpata mmetụta neuroprotective? Anyị kwesịrị n'ezie ọgwụ ọhụrụ iji metụta mmụgharị HDAC5 iji gwọọ ọrịa bipolar?

Mgbanwe HDAC5 na mmetụta neuroprotective nke ketone n'ụzọ a nwere ike ịbụ otu n'ime usoro na-eme ọgwụgwọ nri ketogenic maka ọrịa bipolar? Echere m na ọ nwere ike ịbụ. Ma ndị a bụ ajụjụ niile m na-atụ anya ịhụ ka a na-arụrịta ụka ma zaa ya n'akwụkwọ nyocha n'ime afọ iri na-abịanụ.

GRIN2A

Ka anyị tụleghachi mkpụrụ ndụ ihe nketa GRIN2A. Mkpụrụ ndụ ihe nketa a na-eme protein GRIN2A. Protein a bụ akụkụ nke ndị na-anabata N-methyl-D-aspartate (NMDA) (ọwa ion). A na-achịkwa ndị na-anabata NMDA, n'otu akụkụ, site na glutamate ma na-eziga mgbama na-akpali akpali na ụbụrụ. Ndị na-anabata NMDA na-etinye aka na synapti plasticity (mmụta na ebe nchekwa) ma na-ekere òkè na ụra miri emi. M na-agụnye mmetụta nke ketones na ụzọ NMDA ebe a, nke ka ukwuu n'ihi na ndị na-anabata ya na-achịkwa glutamate.

Mana enwere m ike itinye ya ngwa ngwa na mpaghara mbufụt ma ọ bụ oxidative nke post a. N'ihi na mgbe glutamate dị elu, ọ na-abụkarị n'ihi neuroinflammation na-emetụta mmepụta na nguzozi nke neurotransmitter. Mara na ahaghị nhata na sistemu neurotransmitter (dịka ọmụmaatụ, mmụba glutamate na ọrụ nnabata NMDA; mmụba NMDA-excitotoxicity) jikọtara ya na ọrịa bipolar. Ketones na-edozi mbufụt ozugbo ma na-emetụta mmepụta glutamate nke mere na a na-ebelata mbufụt ma mee glutamate n'ụzọ ziri ezi na oke.

SCN2A

SCN2A bụ mkpụrụ ndụ ihe nketa na-enye ntụziaka maka ịmepụta protein ọwa sodium a na-akpọ NaV1.2. Protein a na-enye neuron ohere iji akara eletrịkị nke a na-akpọ ike ịkparịta ụka. A na-eji nri ketogenic eme ogologo oge iji gwọọ ọrịa akwụkwụ ma jiri ya mee ihe kpọmkwem iji gwọọ ndị nwere mmụgharị mkpụrụ ndụ ihe nketa na SCN2A. Ekwetaghị m na ọ bụ ihe na-enweghị ezi uche na-agbatị iche n'echiche na nri ketogenic nwere ike inye aka na-emeso mgbanwe dị iche iche nke mkpụrụ ndụ ihe nketa na SCN2A gene nke anyị na-ahụ na ndị bipolar.

CACNA1C

Achọpụtakwara CACNA1C dị ka inwe mmekọrịta siri ike na ọrịa bipolar. Ọ na-emetụtakwa ọwa calcium na-adabere na voltaji, nke dị mkpa maka ọrụ akpụkpọ anụ na neuron. Ị chọrọ akpụkpọ ahụ cell neuronal ahụike iji mezuo ebumnuche dị mkpa dị ka nchekwa nri, mmepụta neurotransmitter, na nkwurịta okwu n'etiti sel.

CACNA1C na-enyere aka na ọrụ subunit alpha1 calcium channel. Ma ọ bụ ezie na ọkwa dị ugbu a nke mkpụrụ ndụ ihe nketa biochemistry adịghị ekwe ka m chọta ụzọ a nke ọma, amaara m na ihe a na-akpọ paroxysmal depolarization shifts (PDS) na-eche na ọ na-etinye aka na nkwụsị nke epileptic. Nri ketogenic na-egosi na ọ na-eme ka mgbanwe depolarization na ndị mmadụ nwere ọrịa akwụkwụ kwụsie ike, a na-eche na nke a bụ otu n'ime usoro nri ketogenic na-arụ ọrụ na ọnụ ọgụgụ a. Na site na ọrụ, m na-ekwu n'ezie belata na mgbe ụfọdụ kwụsị ọdịdọ.

Mweghachi nke ọma na nkwụsi ike akpụkpọ ahụ nwekwara ike ime na-apụtaghị ìhè site n'ịbawanye ike cell na ịgafe metabolism nke ụbụrụ na-adịghị arụ ọrụ. Ketones na-enye isi iyi ike a ka mma, yabụ na ketones nwere ike ọ gaghị emetụta okwu ụzọ CACNA1C ozugbo, ha nwere ike inye ọgwụgwọ maka mmetụta nke CACNA1C snip na-emetụta akara ngosi bipolar.

A na-agwọ ọrịa ọdịdọ site na iji nri ketogenic kemgbe 1920, na mmetụta ndị a ka edekọtara nke ọma na enweghị mgbagha n'oge a. Mmetụta nke ketones na ọwa calcium na repolarization nke neuronal membranes bụ nke a na-edepụta nke ọma na akwụkwọ akwụkwụ.

Mana isi ihe m na-ekwu bụ na nri ketogenic na-agwọ ọnya ọwa calcium na-emeziwanye ahụike na arụ ọrụ neuronal. Ya mere, gịnị kpatara na ọ gaghị arụ ọrụ inyere ndị nwere ọrịa bipolar aka? Nke a enweghị ike ịbụ usoro ọzọ nke nri ketogenic nwere ike inye aka belata mgbaàmà bipolar?

mmechi

Ndị a bụ ihe atụ nke mkpụrụ ndụ ihe nketa amata dị ka ndị nwere mmetụta na usoro ọrịa nke ọrịa bipolar, enwere ike ịhazi ya site na omume ketones ozugbo ma ọ bụ ala na ngwaahịa ndị na-arụ ọrụ ndụ nke a na-eme yana otu esi eji ha. Ya mere, ọ bụ ezie na e nwere akụkụ dị ịrịba ama nke mkpụrụ ndụ ihe nketa na-akpata ọrịa bipolar, e nwekwara ụzọ isi metụta mkpụrụ ndụ ihe nketa ndị ahụ na otú e si akọwa ha, na-agbanwe otú e si egosipụta ha n'ụzọ ndị dị mkpa.

Ọ dị m mkpa na ị maara ụzọ niile ị ga-esi nweta ahụ iru ala, na ị ghọtara na naanị n'ihi na ihe bụ mkpụrụ ndụ ihe nketa, ọ pụtaghị na ị gaghị agbanye ụfọdụ mkpụrụ ndụ ihe nketa ndị ahụ site n'ụdị ndụ gị ma ọ bụ ihe ndị ọzọ. Ma ọ pụtaghị na mkpụrụ ndụ ihe nketa gị ga-ekpebi ọdịnihu gị ma a bịa n'ọrịa na-adịghị ala ala - ọbụlagodi ọrịa mgbaka na-adịghị ala ala, dị ka ọrịa bipolar.

Ọgba aghara bipolar (BD) bụ nsogbu mgbaka mgbaka siri ike nke a na-eji steeti manic na nkụda mmụọ na-ese okwu ugboro ugboro. Na mgbakwunye na ihe mkpụrụ ndụ ihe nketa, Mgbagwoju anya mkpụrụ ndụ ihe nketa gburugburu ebe obibi, nke na-agbanwe ọnọdụ epigenetic na ụbụrụ, na-enye aka na etiology na pathophysiology nke BD..

(agbakwunyere ike) Sugawara, H., Bundo, M., Kasahara, T. et al., (2022). https://doi.org/10.1186/s13041-021-00894-4

Ọ bụrụ na ị nwere mmasị na blọọgụ a gbasara ihe mkpụrụ ndụ ihe nketa na ọrịa bipolar, ị ga-ahụta ọkwa blọgụ m na nri ketogenic maka ọrịa bipolar na-enyere aka.

Dị ka ihe ị na-agụ na blọgụ? Chọrọ ịmụta maka webinars na-abịa, nkuzi na ọbụna na-enye nkwado na iso m na-arụkọ ọrụ maka ebumnuche ọdịmma gị? debanye aha!

Ị nwekwara ike ịhụ na blọgụ ndị a na-enye aka na njem ọgwụgwọ gị:

Dị ka mgbe niile, blọọgụ a abụghị ndụmọdụ ahụike.


References

Beurel, E., Grieco, SF, & Jope, RS (2015). Glycogen synthase kinase-3 (GSK3): Iwu, omume, na ọrịa. Nkà ọgwụ na ọgwụgwọ, 0, 114. https://doi.org/10.1016/j.pharmthera.2014.11.016

Bhat, S., Dao, DT, Terrillion, CE, Arad, M., Smith, RJ, Soldatov, NM, & Gould, TD (2012). CACNA1C (Cav1.2) na pathophysiology nke ọrịa psychiatric. Ọganihu na Neurobiology, 99(1), 1-14. https://doi.org/10.1016/j.pneurobio.2012.06.001

Chen, S., Xu, D., Fan, L., Fang, Z., Wang, X., & Li, M. (2022). Ọrụ N-Methyl-D-Aspartate Nnabata (NMDARs) na Akwụkwụ na-adọ. Frontiers na Molecular Neuroscience, 14, 797253. https://doi.org/10.3389/fnmol.2021.797253

Cohen, P., & Goedert, M. (2004). GSK3 inhibitors: Mmepe na ike ọgwụgwọ. Nlebanya okike. Nchọpụta ọgwụ, 3, 479-487. https://doi.org/10.1038/nrd1415

Conde, S., Pérez, DI, Martínez, A., Perez, C., & Moreno, FJ (2003). Thienyl na phenyl alpha-halomethyl ketones: Ndị na-egbochi glycogen synthase kinase (GSK-3beta) ọhụrụ sitere na ọbá akwụkwọ nke nyocha ngwa. Journal of Medicinal Chemistry, 46(22), 4631-4633. https://doi.org/10.1021/jm034108b

Erro, R., Bhatia, KP, Espay, AJ, & Striano, P. (2017). Akwụkwụ na-adọ na nke na-adịghị na ya nke paroxysmal dyskinesias: Channelopathies, synaptopathies, na transportopathies. Nsogbu ndị na-eme njem, 32(3), 310-318. https://doi.org/10.1002/mds.26901

Ghasemi, M., & Schachter, SC (2011). Ihe mgbagwoju anya NMDA dị ka ebumnuche ọgwụgwọ na Akwụkwụ na-adọ: nyocha. Akwụkwụ na-adọ & Omume, 22(4), 617-640. https://doi.org/10.1016/j.yebeh.2011.07.024

Mkpụrụ ndụ GRIN2A: MedlinePlus Genetics. (nd). Eweghachitere Jenụwarị 29, 2022, site na https://medlineplus.gov/genetics/gene/grin2a/

Haggarty, SJ, Karmacharya, R., & Perlis, RH (2021). Ọganihu na ọgwụgwọ ziri ezi maka ọrịa bipolar: Mechanisms & molecules. Ọrịa na-enweghị isi, 26(1), 168-185. https://doi.org/10.1038/s41380-020-0831-4

Hensley, K., & Kursula, P. (2016). Collapsin Response Mediator Protein-2 (CRMP2) bụ Factor Etiological Plausible na Pụrụ Iche Therapeutic Target na Ọrịa Alzheimer: Ntụle na Ntule na Microtubule-Associated Protein Tau. Akwụkwọ nke Ọrịa Alzheimer, 53(1), 1-14. https://doi.org/10.3233/JAD-160076

Jope, RS, Yuskaitis, CJ, & Beurel, E. (2007). Glycogen Synthase Kinase-3 (GSK3): Mbufụt, Ọrịa, na Ọgwụgwọ. Nnyocha Neurochemical, 32(4–5), 577 . https://doi.org/10.1007/s11064-006-9128-5

Knisatschek, H., & Bauer, K. (1986). Mgbochi a kapịrị ọnụ nke proline cleaving enzyme site na benzyloxycarbonyl-Gly-Pro-diazomethyl ketone. Nyocha Mgbasa Ozi na Biophysical Research, 134(2), 888-894. https://doi.org/10.1016/s0006-291x(86)80503-4

Ko, A., Jung, DE, Kim, SH, Kang, H.-C., Lee, JS, Lee, ST, Choi, JR, & Kim, HD (2018). Ịdị irè nke nri Ketogenic maka mmụgharị mkpụrụ ndụ ihe nketa akọwapụtara na mmepe na Epileptic Encephalopathy. Ala dị ala na Neurology, 9. https://doi.org/10.3389/fneur.2018.00530

Kubista, H., Boehm, S., & Hotka, M. (2019). The Paroxysmal Depolarization Shift: Ịtụleghachi Ọrụ Ya na Akwụkwụ na-adọ, Epileptogenesis na Gafe. Akwụkwọ bụ International Journal of Scholarships, 20(3), 577. https://doi.org/10.3390/ijms20030577

Lett, TAP, Zai, CC, Tiwari, AK, Shaikh, SA, Likhodi, O., Kennedy, JL, & Müller, DJ (2011). ANK3, CACNA1C na ZNF804A gene variants in bipolar disorders and psychosis subphenotype. Akwụkwọ bụ World Journal of Biological Psychiatry, 12(5), 392-397. https://doi.org/10.3109/15622975.2011.564655

Lund, TM, Ploug, KB, Iversen, A., Jensen, AA, na Jansen-Olesen, I. (2015). Mmetụta metabolic nke β-hydroxybutyrate na neurotransmission: Mbelata glycolysis na-eme mgbanwe na nzaghachi calcium na mmetụta uche nke ọwa KATP. Akwụkwọ Neurochemistry, 132(5), 520-531. https://doi.org/10.1111/jnc.12975

Marx, W., McGuinness, AJ, Rocks, T., Ruusunen, A., Cleminson, J., Walker, AJ, Gomes-da-Costa, S., Lane, M., Sanches, M., Diaz, AP , Tseng, P.-T., Lin, P.-Y., Berk, M., Clarke, G., O'Neil, A., Jacka, F., Stubbs, B., Carvalho, AF, Quevedo, J., … Fernandes, BS (2021). Ụzọ kynurenine na nnukwu nsogbu ịda mbà n'obi, ọrịa bipolar, na schizophrenia: meta-analysis nke ọmụmụ 101. Ọrịa na-enweghị isi, 26(8), 4158-4178. https://doi.org/10.1038/s41380-020-00951-9

Mikami, D., Kobayashi, M., Uwada, J., Yazawa, T., Kamiyama, K., Nishimori, K., Nishikawa, Y., Morikawa, Y., Yokoi, S., Takahashi, N., Kasuno, K., Taniguchi, T., & Iwano, M. (2019). β-Hydroxybutyrate, ahụ ketone, na-ebelata mmetụta cytotoxic nke cisplatin site na ịgbalite HDAC5 n'ime mkpụrụ ndụ epithelial gbasara akụrụ mmadụ. Nkà Mmụta Ndụ, 222, 125-132. https://doi.org/10.1016/j.lfs.2019.03.008

Mullins, N., Forstner, AJ, O'Connell, KS, Coombes, B., Coleman, JRI, Qiao, Z., Als, TD, Bigdeli, TB, Børte, S., Bryois, J., Charney, AW , Drange, OK, Gandal, MJ, Hagenaars, SP, Ikeda, M., Kamitaki, N., Kim, M., Krebs, K., Panagiotaropoulou, G., … Andreassen, OA (2021). Ọmụmụ ihe gbasara mkpokọta genome nke ihe karịrị 40,000 ọrịa ọrịa bipolar na-enye nghọta ọhụrụ na bayoloji dị n'okpuru. Nature Genetics, 53(6), 817-829. https://doi.org/10.1038/s41588-021-00857-4

Nyegaard, M., Demontis, D., Foldager, L., Hedemand, A., Flint, TJ, Sørensen, KM, Andersen, PS, Nordentoft, M., Werge, T., Pedersen, CB, Hougaard, DM, Mortensen, PB, Mors, O., & Børglum, AD (2010). CACNA1C (rs1006737) jikọtara ya na schizophrenia. Ọrịa na-enweghị isi, 15(2), 119-121. https://doi.org/10.1038/mp.2009.69

SCN2A.com. (nd). Ụlọ ọrụ SCN2A.Com. eweghachite Jenụwarị 29, 2022, site na https://scn2a.com/scn2a-overview/

Sugawara, H., Bundo, M., Kasahara, T. et al. Ụdị cell-kpọmkwem DNA methylation nyocha nke cortices ihu nke mutant Ugbogho 1 ụmụ oke transgenic nwere mkpokọta neuronal nke DNA mitochondrial ehichapụ. Mol Brain 15, 9 (2022). https://doi.org/10.1186/s13041-021-00894-4

Thaler, S., Choragiewicz, TJ, Rejdak, R., Fiedorowicz, M., Turski, WA, Tulidowicz-Bielak, M., Zrenner, E., Schuettauf, F., & Zarnowski, T. (2010). Neuroprotection site na acetoacetate na β-hydroxybutyrate megide NMDA-ebutere RGC mmebi na oke - Ntinye aka nke kynurenic acid enwere ike. Ebe nchekwa Graefe maka ụlọ ọgwụ na nyocha anya = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 248(12), 1729-1735. https://doi.org/10.1007/s00417-010-1425-7

Ọtụtụ ihu Beta-hydroxybutyrate (BHB). (2021, Septemba 27). KetoNutrition. https://ketonutrition.org/the-many-faces-of-beta-hydroxybutyrate-bhb/

Tian, ​​X., Zhang, Y., Zhang, J., Lu, Y., Men, X., & Wang, X. (2021). Nri Ketogenic n'ime ụmụ ọhụrụ nwere Encephalopathy Epileptic mmalite mmalite yana Mgbanwe SCN2A. Akwụkwọ akụkọ Ahụike Yonsei, 62(4), 370-373. https://doi.org/10.3349/ymj.2021.62.4.370

β-Hydroxybutyrate Modulate N-Type Calcium Channels na Rat Sympathetic Neurons site na-eme dị ka Agonist maka G-Protein-Coupled Nnabata FFA3-PMC. (nd). Eweghachitere Jenụwarị 29, 2022, site na https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3850046/

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