Nri ketogenic ọ nwere ike ịgwọ ọrịa bipolar?

Ihe akaebe na-arị elu na-akwado iji nri ketogenic eme ihe maka ọrịa bipolar n'ihi ikike nri ketogenic iji gbanwee usoro ọrịa ndị dị n'okpuru dị ka ụbụrụ hypometabolism, neurotransmitter imbalances, mbufụt ụbụrụ, na nrụgide oxidative. Enwere ọtụtụ akụkọ gbasara akụkọ ihe mere eme, akwụkwọ akụkọ ndị e bipụtara na akwụkwọ akụkọ ndị ọgbọ na-enyocha, isiokwu na-enyocha akwụkwọ ndị dị na isiokwu ahụ, na nyocha ndị a na-achịkwa nke a na-achịkwa na-enyocha nri ketogenic dị ka ọgwụgwọ maka ọrịa bipolar.

Okwu Mmalite

A na-ewerekarị ihe omume manic na BPD ka a na-ejikwa ọgwụ eme ihe nke ọma. Mana nnukwu ọnọdụ ịda mbà n'obi ka na-ewere dị ka ihe na-eme ugboro ugboro yana nnukwu ihe ịma aka ụlọ ọgwụ. Ndị mmadụ na-arịa ọrịa bipolar na-ata ahụhụ site na nnukwu mgbaàmà ịda mbà n'obi, ọbụlagodi maka ndị ọrịa ahụ na-enwe mmetụta nke ọgwụ na-achịkwa nke ọma.

Usoro ndị a nwere ike ịmepụta nrụrụ arụ ọrụ na nkwarụ na-adịgide adịgide ma mee ka ohere igbu onwe ya dịkwuo elu. Ịdabere na ọgwụ ndị na-adịghị arụ ọrụ iji gwọọ akụkụ ịda mbà n'obi nke ọrịa bipolar bụ ma obi ọjọọ ma nwee ike dị ize ndụ. Ọ bụrụgodị na ọ bụ ụkpụrụ nlekọta. Ndị na-eme ka ọnọdụ uche dị ugbu a maka oge ịda mbà n'obi nke ọrịa bipolar na-arụ ọrụ naanị na 1/3 nke ndị na-arịa ọrịa bipolar na ndị na-ahụ maka antidepressants na-egosi ugboro ugboro na-egosi uru na RCT maka ọnọdụ a ma nwee ike ime ka ọnọdụ ahụ dịkwuo njọ. A na-akọ na antipsychotics atypical na-arụ ọrụ nke ọma mana ha na-enwe mmetụta na-emebi emebi metabolic nke na-eme ka ojiji ogologo oge adịghị mma yana mmetụta-adịghị mma maka ndị ọrịa.

Edere m ihe a dị n'elu iji gosi ọnọdụ nke ọtụtụ ndị na-arịa ọrịa bipolar, na ịkọwapụta na ọ bụrụgodị na onye nwere ọrịa bipolar enwetala mgbaàmà manic ha na-achịkwa na ọgwụ (ọtụtụ enweghị), a ka nwere akụkụ dị ịrịba ama nke bipolar. ndị mmadụ na-ata ahụhụ site na mgbaama mpụta.

Ha kwesịkwara ịma ụzọ niile ha ga-esi na-enwekwu obi ụtọ.

Atụpụtala ọtụtụ usoro ndu dị ka ihe nwere ike ịkpata BD. Ndị a gụnyere arụrụ arụ mitochondrial, nrụgide oxidative na ọgba aghara neurotransmitter.

Yu, B., Ozveren, R., & Dalai, SS (2021). Nri ketogenic dị ka ọgwụgwọ metabolic maka ọrịa bipolar: mmepe ụlọ ọgwụ. https://www.researchsquare.com/article/rs-334453/v2

Dị ka anyị na-atụle glucose hypometabolism, neurotransmitter adịghị mma, mbufụt, nrụgide oxidative, na otú nri ketogenic si agbanwe ihe ndị ahụ, ị ​​ga-amalite ịghọta ihe mere ndị mmadụ ji eme nri ketogenic maka ọrịa bipolar.

Ka anyị malite!

Ọrịa Bipolar na Hypometabolism

Isi ihe na-akpata ọrịa metabolic chere na ọ ga-ekere òkè gụnyere arụ ọrụ nke metabolism ike.

Yu, B., Ozveren, R., & Dalai, SS (2021). Ojiji nke obere carbohydrate, nri ketogenic na ọrịa bipolar: nyocha usoro. https://www.researchsquare.com/article/rs-334453/v1

Gịnị bụ ụbụrụ hypometabolism? Ma ndị nwere ọrịa bipolar hà nwere hypometabolism?

Ụbụrụ hypometabolism pụtara nanị na mkpụrụ ndụ ụbụrụ anaghị eji ike eme ihe nke ọma n'akụkụ ụfọdụ nke ụbụrụ ma ọ bụ n'ụdị ụfọdụ. 

  • hypo = obere
  • metabolism = ume eji eme ihe

Ndị nwere ọrịa bipolar nwere mpaghara ụbụrụ hypometabolism, nke pụtara na akụkụ ụbụrụ ndị ahụ anaghị arụ ọrụ dịka ha kwesịrị ịdị. Ụbụrụ hypometabolism bụ n'ezie banyere arụ ọrụ mitochondrial, nke bụ isi ka ụbụrụ si eji mmanụ ọkụ na otú o si emepụta ike.

Ọ bụghị naanị otu akụkụ nke ụbụrụ anyị na-ahụ mịtochondrial dysfunction na-arụ ọrụ dị ka ụkọ ume. Ụfọdụ akụkụ ụbụrụ ndị a chọpụtara dị ka hypometabolic site na teknụzụ neuroimaging dị iche iche gụnyere insula, ụbụrụ ụbụrụ, na cerebellum.

Enwekwara ihe akaebe zuru oke nke hypometabolism na-akpata ọgba aghara n'ime ihe ọcha dị n'ihu. Mgbagha ndị a nke nhazi cell na metabolism na-apụta n'ime ihe ọcha nke ụbụrụ n'etiti netwọk ihu-limbic. Maka ndị ọhụrụ na aha nhazi ụbụrụ ndị a, usoro limbic gị bụ etiti mmetụta uche nke ụbụrụ. Ma ọ dị mkpa ịghọta na mmetụta uche gị nwere ike ịbịa site na nyocha gị banyere ọnọdụ (oh nke ahụ bụ agụ na ha na-eri ndị mmadụ!) Na ozi ahụ na-aga na usoro limbic gị iji malite nzaghachi (RUN!). N'ọgba aghara bipolar, anyị na-ahụ nsogbu njikọta ihe ọcha na netwọkụ isi ọgụgụ isi nke gụnyere dorsolateral prefrontal cortex, mpaghara oge na parietal. Nke bụ isi akụkụ niile dị oke mkpa ịchọrọ ịrụ ọrụ ma gbaa ume nke ọma.

Ebe ndị a chọpụtara na ụbụrụ ụbụrụ hypometabolism abụghị ihe ijuanya mgbe anyị na-eche banyere mpụta nke mmetụta mmetụta na àgwà mgbaàmà na ọrịa bipolar. Ọmụmaatụ:

  • mebie njikọ n'etiti cingulate cortex dorsal, na precuneus, cuneus.
    • A na-eche na njikọ a mebiri emebi nwere ike iso na-esote ngafe-mmeghachi omume n'oge nhazi mmetụta uche na ndị ọrịa bipolar
  • nnukwu cortex prefront
    • na-achịkwa ọrụ ndị isi dị ka ịhazi atụmatụ, ebe nchekwa ọrụ, na nlebara anya nhọrọ.
  • dorsal cingulate cortex
    • nchịkwa nchịkwa (nke ịkwesịrị ịhazi mmetụta uche), mmụta, na njide onwe onye.
    • A na-ahụ hypometabolism na cortex cingulate na ndị nwere nsogbu iji ihe eme ihe
  • precuneus
    • nghọta nke gburugburu ebe obibi, ihe ngosi mmeghachi omume, atụmatụ echiche echiche, ncheta episodic iweghachite, na mmeghachi omume na-emetụta mgbu.

Ma chere otu nkeji, ị nwere ike ikwu. Mmeghachi omume karịrị akarị? Kedu ka nke ahụ nwere ike isi mee na ụbụrụ nwere hypometabolism mgbe anyị na-atụ anya na enweghi ike zuru oke maka imebiga ihe ókè? Ọzọkwa, ọ bụ na akụkụ ụfọdụ nke ọrịa bipolar adịghị eme ka onye ọ bụla nwee ụdị iwe ọkụ? Dị ka ha enweghị ike ịkwụsị ma ọ bụ hie ụra? Kedu ka nke a si emetụta?

Ọfọn, azịza ya bụ ntakịrị ihe mgbagwoju anya. Mgbe ụfọdụ akụkụ ụbụrụ na-enweghị ike zuru ezu iji rụọ ọrụ, ọ nwere ike ịkpata mmetụta ala nke na-akpaghasị nguzozi neuronal na mpaghara ndị ọzọ. Yabụ hypometabolism n'akụkụ ụfọdụ nke ụbụrụ na-atụpụ sistemu ahụ siri ike nke ụbụrụ, ọ na-ejedebe na-adịgide adịgide nke neurotransmitter n'akụkụ niile ma ọ bụ n'akụkụ akụkụ, na-eme ka hyperexcitability na ọkwa neurotransmitter. nke anyị ga-atụle karịa na ngalaba ndị ọzọ (lee Neurotransmitter Imbalances). Hypometabolism n'otu akụkụ nke ụbụrụ nwere ike ime ka ụbụrụ nwee ọtụtụ njikọ na akụkụ ụbụrụ ndị ọzọ, na-agbalị ịkwụ ụgwọ. Ị nwere ike mechie site na njikọta n'etiti mpaghara ndị na-abụghị ezigbo njikọ.

Enweghi ike nke mkpụrụ ndụ ụbụrụ inwe ike zuru oke site na isi iyi mmanụ ọkụ kwụsiri ike na-eme ka arụ ọrụ mitochondrial dịgidere. Mitochondria bụ batrị nke mkpụrụ ndụ gị, ọ dịkwa ha mkpa iji mezuo ihe niile neuron kwesịrị ime. Ọ bụrụ na mmanụ ụbụrụ gị anaghịzi arụ ọrụ maka gị, nke n'ihe gbasara glucose na ọrịa bipolar nwere ike bụrụ nke ọma, batrị ndị ahụ enweghị ike ịrụ ọrụ. Neurons enweghị ike zuru oke iji rụọ ọrụ wee malite ịrụ ọrụ nke ọma! Neuron na-arụ ọrụ na-adịghị mma enweghị ike ịrụ ọrụ ụlọ cell bụ isi, mee neurotransmitters, ma ọ bụ ọbụna debe neurotransmitters ahụ maka oge kwesịrị ekwesị na synapse, ma ọ bụ ọbụna nwee ike ịkparịta ụka nke ọma na sel ndị ọzọ.

N'ihi na ha nọ n'ahụhụ, ha na-emepụta ọkwa ha nke mbufụt na oxidation, na-eji ihe ndị dị oké ọnụ ahịa (vitamin na mineral) na-agbalị ịlụso mbufụt na-eme n'ihi na cell nọ na nhụjuanya site na ụkọ ike. Na-ebelata cell n'ihu ma na-agbakwunye na ike adịghị ike na neuron.  

Otu n'ime echiche kpatara nke a ji eme bụ na metabolism nke glucose na-emebi ụbụrụ n'ihi ngbanwe na-adịghị mma nke enzyme dị mkpa a na-akpọ pyruvate dehydrogenase complex (PDC). Nsogbu dị n'ịgbanwe glucose dị ka isi iyi mmanụ ọkụ maka ụbụrụ ụbụrụ nwere nnukwu nsonaazụ.

Nke a hypometabolism, na mitochondrial dysfunction na-esote, dị mkpa na ụbụrụ bipolar, na ndị nchọpụta nwere ike ime ụmụ oke transgenic na ụbụrụ ụbụrụ mitochondrial kpọmkwem, na-emepụtaghachikwa ihe mgbaàmà nke mmadụ bipolar na-enweta!

Na, mgbe ha na-agwọ ụmụ oke transgenic ndị a na lithium ma ọ bụ ọbụna antidepressants mgbe niile, ha na-emeghachi omume n'otu ụzọ ahụ ndị ọrịa bipolar mmadụ na-eme ọgwụ ndị ahụ.

Ya mere, okwu m bụ nke a. Hypometabolism bụ nnukwu ihe na-eme ka e kee ihe na-aga n'ihu na mgbaàmà bipolar. Ọ kwesịrị nlebara anya dị ka ihe mgbaru ọsọ kpọmkwem nke ntinye aka na ọrịa bipolar.

Ugbu a, ka anyị tụlee ka nri ketogenic, ọgwụgwọ a ma ama maka ọrịa metabolic, nwere ike isi nyere aka.

Otu keto si agwọ ọrịa hypometabolism na ọrịa bipolar

Nri ketogenic bụ ezigbo enyi neuron. Ọbụghị naanị na ha na-enye isi iyi mmanụ ọzọ maka glucose n'ụdị ketones, ike ketone a na-adaba na neuron, na-agafe usoro enzyme pụrụ iche ma ọ bụ ọrụ ụgbọ njem na-ezighi ezi. Nke a na-emeziwanye ike metabolism na-enye ụbụrụ bipolar ume ime ihe niile ọ chọrọ ime, nke ka mma karịa ka ọ nwere na mbụ.

Dị ka a ga-asị na inwe mmanụ mmanụ ka mma nke ụbụrụ nwere ike iji nke ọma ezughị, ketone n'onwe ya bụ ahụ na-egosi mkpụrụ ndụ ihe nketa. nke a pụtara na ha nwere ike ịgbanwuo ma gbanyụọ mkpụrụ ndụ ihe nketa n'ụzọ dị iche iche. Otu n'ime ihe ndị a ketone na-eme bụ ịgba mkpụrụ ndụ ume ka ọ na-emekwu mitochondria. Ketones na-abawanye ike ụbụrụ n'ụzọ nkịtị site n'ịmepụta ọtụtụ batrị cell ahụ wee nye mmanụ ọkụ n'ime ha.

Ọ bụrụ na ị ka na-ekwenyeghị na nri ketogenic kwesịrị ka a na-ewere dị ka ọgwụgwọ maka hypometabolism a na-ahụ na ọrịa bipolar, ọ nwere ike ịbara gị uru ịmụta otú ụfọdụ mgbaàmà nke ọrịa bipolar si yie ihe anyị na-ahụ na ọrịa neurodegenerative.

Usoro nke hypometabolism na ụbụrụ na ọrịa bipolar, yiri ọrịa Alzheimer, na n'ime ndị ọrịa meworo agadi, nchọpụta dị iche na-esiri ike ma mgbe ụfọdụ ọ gaghị ekwe omume.

Nsonaazụ anyị na-ekpughe ihe njirimara neurocognitive na-ahụkarị na ndị ọrịa bipolar nwere nkwarụ ọgụgụ isi nke a na-enyo enyo na neurodegenerative sitere na ha na-atụ aro itinye aka na ọrịa dị iche iche na-akpata…

Musat, EM, et al., (2021). Àgwà nke ndị ọrịa bipolar nwere nkwarụ ọgụgụ isi nke mmalite Neurodegenerative a na-enyo enyo: Otu ìgwè Multicenter. https://doi.org/10.3390/jpm11111183

N'ezie, ọrịa bipolar na-egosipụta ọtụtụ ihe na-adịghị mma, ma na ụbụrụ metabolism na ụzọ mgbaàmà dị ka ọtụtụ ọrịa neurodegenerative, gụnyere ọrịa Alzheimer (AD), Lewy Body Dementia, na ọbụna akụkụ ụfọdụ nke ọrịa Parkinson.

Nri ketogenic bụ ọgwụgwọ dabere na ọrịa Alzheimer, yana ọtụtụ RCT na-egosi uru. Gịnị kpatara na ọ gaghị enyere otu mpaghara ụbụrụ aka na-alụ ọgụ na ike na metabolism? Karịsịa mgbe anyị nwere ike ịhụ na ọtụtụ mpaghara ụbụrụ na-emetụta.

Olee otú anyị si mara nke a? Anyị nwere ọmụmụ ihe onyonyo ụbụrụ RCT ma na-egosi ọrụ dị mma na ụbụrụ kpọmkwem na ndị nwere ọrịa bipolar bụ ndị na-eri nri ketogenic? Ọ bụghị na m hụrụ. Mana ejiri m n'aka na ha na-abịa. N'ihi na anyị na-ahụ nnukwu mbelata na mgbaàmà n'ọtụtụ ndị nwere ọrịa bipolar na-akwaga na nri ketogenic. Ma ụfọdụ n'ime mbelata mgbaàmà ahụ na-esite n'ike ụbụrụ ka mma.

Nri ketogenic na-enye ohere ka ụbụrụ bipolar na-ebuli ketones maka mmanụ ọkụ ma jiri ya mee ihe kama isi glucose maka mmanụ. Nke a na-abawanye mmanụ ọkụ bụ usoro nnapụta maka ụbụrụ ụbụrụ. Ịnyekwu ume n'ime cell na-enye ohere ịrụzi cell, mmezi, mgbasa ozi neuron ka mma, ikike ime ihe ka mma, ị kpọrọ ya aha. Ụbụrụ gị chọrọ ume zuru oke iji mee ya.

Enwere ebe dị ụtọ na nyocha n'ọdịnihu iji kpachapụ mmekọrịta nke metabolism na sistemu neurotransmitter dị iche iche. N’ihi ya, ruo mgbe a ga-eme nnyocha ahụ, anyị ga na-atụle nke ọ bụla n’akụkụ dị iche iche. Ọ bụ oge ịkwaga site na hypometabolism gaa na ahaghị nhata nke neurotransmitter.

Ọrịa BIpolar na Neurotransmitter enweghị atụ

Enwere ọtụtụ ụdị kemịkalụ neurotransmitter dị n'ụbụrụ. Ndị neurotransmitters etinyere na ọrịa bipolar gụnyere dopamine, norepinephrine, serotonin, GABA (gamma-aminobutyrate), na glutamate. Acetylcholine na-etinyekwa aka mana agaghị enyocha ya na blọgụ a. Mgbe anyị na-ekwu maka ahaghị nhata nke neurotransmitter, ọ dị mkpa ịghọta na ọ bụghị naanị na anyị na-ekwu maka oke ma ọ bụ obere nke ọ bụla. 

Nke ahụ nwere ike ịdị otú ahụ ruo n'ókè ụfọdụ, na ime ka otu na nke ọzọ dị ntakịrị nwere ike inye aka. Mana ihe anyị na-ekwu bụ ka e si emepụta neurotransmitters ma jiri ya. Emebere ndị na-anabata ya ka ha were ndị neurotransmitters banye na sel na-arụ ọrụ nke ọma? Akpụkpọ ahụ cell nwere ike ime akụkụ ya n'ịmepụta neurotransmitter ma ọ bụ na-echekwa nri ọ chọrọ iji mee neurotransmitters? 

Enwere ọtụtụ ndị nnabata maka otu ụdị neurotransmitter? Ọ bụrụ otú ahụ, gịnị ka nke ahụ pụtara ruo ogologo oge onye neurotransmitter na-anọ gburugburu na synapse ka ọ baara uru? Enwere polymorphisms mkpụrụ ndụ ihe nketa na-emetụta enzymes ndị kwesịrị ime ka ndị na-ahụ maka akwara ozi ma ọ bụ na-arụ ọrụ nke imebi ha azụ?

Ị nweta echiche ahụ. Ihe m na-ekwu bụ na mgbe m na-atụle ụfọdụ neurotransmitters n'okpuru ebe a, m na-ede banyere usoro mgbagwoju anya. Na usoro echiche na-ewe mgbanwe n'echiche. Ya mere buru nke ahụ n'uche ka ị na-agụ maka adịghị mma nke neurotransmitter na ọrịa bipolar.

Sistemụ Dopaminergic

Dopamine (DA) ndị na-anabata ihe na ndị na-ebugharị na-arụ ọrụ dị mkpa na pathophysiology nke ọrịa bipolar na steeti manic na ịda mbà n'obi.
Otu nchoputa na-agbanwe agbanwe sitere na agonists dopaminergic na ọmụmụ nyocha. Dopaminergic agonists na-egbochi ndị na-anabata dopamine, yabụ dopamine na-anọ ogologo oge na synapse ahụ ma na-enwe mmetụta dị ukwuu karị. Mgbe ndị na-eme nchọpụta na-eme nke a, ha nwere ike ịmegharị ihe ngosi nke mania ma ọ bụ hypomania na ndị ọrịa bipolar, ma ọ bụ ọbụna ndị nwere ihe na-akpata ọrịa ahụ.

Ụfọdụ nnyocha achọpụtala na ndị ọrịa bipolar nwere ọrụ usoro dopaminergic dị elu yana na ọrụ a nwere ike ịbụ n'ihi ụbara ntọhapụ nke neurotransmitter na nsogbu ijikwa ya site na ọrụ synapti. Enwere ike jikọta ihe ndị a na mgbaàmà manic na-etolite na ndị ọrịa bipolar. Ma ọ dị mkpa iburu n'uche na ụbara ogo nke dopamine ejikọtawo na mmụba nke nrụgide oxidative. Ọ bụ ezie na nke a abụghị akụkụ nrụgide oxidative nke blọọgụ, nrụgide oxidative dị oke mkpa na sistemụ neurotransmitter. Ọ na-egbochi usoro enzymatic dị mkpa ma na-emepụta ụdị ikuku oxygen na-emeghachi omume, nke a na-akpaghasịkwa gburugburu ebe obibi nke neurotransmitters na-agbalị ime, na-enwe mmetụta dị ala.

Sistemụ Norepinephrinergic

Norepinephrine bụ isi neurotransmitter na ọrịa bipolar. Dopamine na-agbanwe na norepinephrine site na enzyme Dopamine-β-hydroxylase (DβH). Mgbe enwere obere ọrụ enzyme a, yabụ obere dopamine tụgharịrị ghọọ norepinephrine, ndị na-amụ ihe na-akọpụta akara ngosi bipolar dị elu na ndenye nlele.

MHPG, ngwaahịa sitere na usoro metabolic nke imepụta norepinephrine (nke a na-akpọ metabolite), ka a na-ewere dị ka ihe nwere ike ime ihe maka ịchọpụta ọnọdụ ọnọdụ. A na-atụ aro metabolite a ka ọ nọchite anya njirimara ụlọọgwụ ka onye ọrịa bipolar na-agbanwe n'etiti steeti dara mbà n'obi na nke mmụọ. Ma mgbe a na-eji lithium, a na-enwe mbelata n'otu ihe ahụ na-emepụta ihe.

Ọrụ Norepinephrine na-egosi na ọ na-agbanwe agbanwe dabere na akụkụ bipolar. A na-akọ ọkwa ọkwa norepinephrine dị ala na ikike nnabata (a2) n'oge ọnọdụ ịda mbà n'obi na ọrụ dị elu n'oge usoro manic.

Sistemụ Glutamatergic

Glutamate bụ neurotransmitter na-akpali akpali nke nwere ọrụ na ọtụtụ usoro dị mgbagwoju anya yana dị mkpa. Anyị na-ahụ oke ọrụ glutamate na ọrịa bipolar.

Ịchọrọ ụfọdụ glutamate, mana ọ bụghị nke ukwuu, yana ịchọrọ itinye uche dị elu na mpaghara ziri ezi. Mgbe ọnọdụ na-adịghị mma na ụbụrụ, maka ihe ọ bụla kpatara ya ma eleghị anya n'ihi mbufụt (dị ka ị ga-amụta banyere mgbe e mesịrị), ụbụrụ ga-eme ka glutamate dị ukwuu (ruo 100x karịa ọkwa nkịtị). Glutamate na ọkwa ndị a bụ neurotoxic na-akpata ịka nká neurodegenerative. Ọtụtụ glutamate na-akpata mmebi nke neurons na synapses ma na-emepụta mmebi nke ụbụrụ ga-anwa ịgbalị ịgwọta (na arụ ọrụ nke mmebi nrụzi agaghị enwe ike ịkwado mgbe nnukwu glutamate na-adịghị ala ala).

Nnyocha na-egosikarị mbelata nke okwu ụmụ irighiri ihe na-etinye aka na mgbasa ozi glutamate n'etiti neurons n'ụbụrụ ndị nwere ọrịa bipolar. Otu echiche bụ na ngafe nke glutamate mgbe niile na ụbụrụ nke ndị ọrịa bipolar na-agbanwe ndị na-anabata ya iji belata mmetụta ndị na-emebi emebi.

Glutamate bụ neurotransmitter na-emetụta ọnọdụ uche. Anyị na-ahụ ọkwa glutamate dị elu n'ọtụtụ ọrịa uche, dị ka nchekasị, nsogbu mgbu, PTSD, na ọrịa bipolar abụghị ihe dị iche n'ịkekọrịta enweghị nrụrụ na-adịghị ahụkebe. Ewezuga na ọrịa bipolar, kama ịmepụta ọgụ ụjọ dị ka ọ nwere ike na onye nwere nchekasị zuru oke, glutamate nwere ike ịhụ na ọkwa dị elu, kpọmkwem n'oge ọrịa manic nke ọrịa ahụ.

Sistemụ GABAergic

GABA bụ neurotransmitter inhibitory nke na-arụ ọrụ dị ka breeki maka ndị neurotransmitters na-akpali akpali dị ka glutamate. GABA na-etinye aka na ọrịa bipolar na-ejikọta ya na ọnọdụ manic na ịda mbà n'obi, na data ụlọ ọgwụ na-egosi na mbelata ọrụ usoro GABA na-ejikọta ya na ịda mbà n'obi na nke manic. Ndị ọkachamara n'akparamàgwà mmadụ ga-edekarị ọgwụ GABA-modulating n'ihi na nke a yiri ka ọ na-enwe mmetụta na-eme ka ọnọdụ obi sie ike na ọrịa bipolar.

A na-enwekarị akara akara (ntụgharị) nke GABA n'ime ụbụrụ nke ndị mmadụ bipolar, na ọ bụ ezie na nke a abụghị nanị maka ọrịa bipolar ma na-eme n'ọrịa uche ndị ọzọ, ọ bụ nchọpụta na-agbanwe agbanwe. A na-eji ọgwụ eme ihe na-elekwasị anya na usoro GABA iji nyere aka na-agwọ oge ịda mbà n'obi nke ọrịa bipolar. Ma njikọ mkpụrụ ndụ ihe nketa na ọmụmụ ihe ọmụmụ postmortem na-egosi ihe na-adịghị mma na usoro mgbaàmà GABA.

Ndị ọrịa nwere mbelata na GABA na-abịa dị ka ndị nwere nkwarụ ọgụgụ isi karịa yana kpọmkwem na njikwa mmechi nke omume.

Sistemụ Serotoninergic

Anyị maara na serotonin na-ekere òkè na ọrịa bipolar. Ihe akaebe na-akwado na ụkọ serotonin (nke a na-akpọkwa 5-HT) na-etinye aka na mania nakwa na ịba ụba ma ọ bụ ịkwalite serotonin nwere mmetụta na-eme ka obi dịkwuo mma n'ọtụtụ ọmụmụ ihe site na iji akara dị iche iche (dịka ọmụmaatụ, nkwụsị nke tryptophan, postmortem, platelet, na neuroendocrine).

Mbelata na ntọhapụ nke serotonin na-ejikọta ya na echiche igbu onwe onye, ​​mgbalị igbu onwe, iwe iwe, na nsogbu ụra. Enwere akara ngosi niile nke ndị nwere nsogbu bipolar na-enweta. Mana dị ka anyị tụlere na mbido blọgụ post, ọgwụ ndị na-anwa ịgbanwe usoro a anaghị ezughị oke iji belata mgbaàmà ndị a na ọnụ ọgụgụ a.

Ọrụ akpụkpọ anụ cell na BDNF

Ị nweghị ike ikwurịta nguzozi nke neurotransmitter na-enweghị mkparịta ụka banyere ọrụ akpụkpọ ahụ. Dị ka ị mụtara na mbụ, mkpụrụ ndụ chọrọ ume iji mee ka ike rụọ ọrụ (mgbagbu cell). Na ihe ndị dị mkpa na-eme mgbe neurons na-ere ọkụ, dị ka ikike ịhazi mkpokọta calcium. Ị ga-enwe akpụkpọ anụ ahụ dị mma iji nweta ume dị mma ma na-achịkwa ọtụtụ mineral dị mkpa ụbụrụ dị mkpa iji mepụta ike ime ihe, na-echekwa ahụ ike nke cell, na-echekwa nri maka mmepụta neurotransmitter na ọrụ enzyme.

Na ọrịa bipolar, nkwụsị nke ọrụ sodium / potassium na mfu nke (sodium) Na +/ (potassium) K+-ATPase Ọrụ (ọrụ enzyme dị mkpa iji mepụta ume) na-eme ma na-enye aka na ụkọ ume nke sel. Mgbanwe na-akpata na arụ ọrụ akpụkpọ ahụ nwere ike imetụta manic na ịda mbà n'obi nke ọrịa bipolar.

Ihe na-akpata neurotrophic nke ụbụrụ (BDNF) bụ ihe a na-eme na ụbụrụ na-enyere aka ịrụzi mkpụrụ ndụ ma na-eme njikọ ọhụrụ maka mmụta na n'etiti akụkụ ụbụrụ. Cheta otú anyị si kwurịta ihe na-adịghị mma nke sekit akwara na ihe ọcha? Ị chọrọ BDNF iji nyere aka megharịa ihe dị otú ahụ. Na ndị nwere ọrịa bipolar enweghị BDNF zuru oke iji mee nke ahụ nke ọma ma ọ bụ na-aga n'ihu na nrụzi dị mkpa site na steeti neuroinflammation na-adịghị ala ala.

Olileanya, blọọgụ a na-amalite ịza ajụjụ nke nri ketogenic nwere ike ịgwọ ọrịa bipolar? Ị nwere ike ịhụ ka mmetụta na nguzozi neurotransmitter si eme ọgwụgwọ nri ketogenic maka ọrịa bipolar.

Kedu ka keto si edozi neurotransmitters

Nri ketogenic nwere mmetụta kpọmkwem na ọtụtụ neurotransmitters. Enwere ọtụtụ ọmụmụ ihe na-egosi mmụba nke serotonin na GABA, yana ịhazi glutamate na dopamine. Enwere ụfọdụ mmekọrịta n'etiti nri ketogenic na norepinephrine nke a na-enyocha ugbu a na nyocha gbasara ọrịa akwụkwụ. O yighị ka mmetụta ketones na norepinephrine ozugbo, mana ala ka ọ na-agbanwe ka ọ bụrụ dopamine.

Nri ketogenic na-edozi mmepụta na ọrụ nke neurotransmitter, yabụ na ị gaghị enweta oke nke otu ma ọ bụ nke nta nke ọzọ, na-emesị nweta mmetụta dịka ị na-eji ọgwụ mgbe ụfọdụ.

Nkwalite nke ụfọdụ neurotransmitters, dị ka GABA, doro anya na ọ bara uru maka ọnọdụ uche yana mmụba ya na-enyere aka ịhazigharị mmepụta glutamate na-akpali akpali. Nke a nwere ike ịbụ usoro anyị na-ahụ ihu ọma na ndị mmadụ bipolar, ma nwee ike imetụta mbelata steeti manic ozugbo.

Usoro ọzọ dị mkpa nke anyị na-ahụ maka ndozi na nguzozi nke neurotransmitter bụ n'ịrụ ọrụ akpụkpọ ahụ cell ka mma. Nri ketogenic na-ewusi nkwukọrịta n'etiti mkpụrụ ndụ ike ma na-enyere aka ịhazi mbata nke micronutrients (cheta sodium, potassium, na calcium?) achọrọ maka ịgba egbe cell. Ọrụ akpụkpọ ahụ na-eme ka ọ dịkwuo mma na-apụtakwa site na usoro nke na-emeziwanye (na-eme ka ọ dịkwuo) BDNF, ya mere sel na akpụkpọ anụ sel na-enwe ike ịrụzi onwe ha. Ma dị ka ego agbakwunyere, mmụba a na ọrụ akpụkpọ ahụ cell na-enye ohere maka akpụkpọ ahụ iji chekwaa micronutrients dị mkpa iji mepụta neurons wee malite nrụzi (iji BDNF ahụ dị egwu na-enye).

Mana dị ka anyị ga-amụta n'okpuru ebe a, enweghi ike ime neurotransmitters nke ọma ma ọ bụ n'ụzọ ziri ezi na gburugburu ebe a na-awakpo mgbe niile ma na-achịkwa ya site na mbufụt. Ya mere, anyị na-akwụsị mkparịta ụka anyị banyere neurotransmitters ma ọ bụ naanị n'ihe metụtara usoro ọrịa ndị ọzọ na-eme na ụbụrụ bipolar, nke gụnyere mbufụt na nrụgide oxidative.

Ọrịa Bipolar na Mbufụt

Mbufụt bụ okwu dị na ọrịa bipolar nke na ọ bụ akụkụ dị mkpa nke nyocha naanị ya ma mara ya dị ka usoro dị mkpa na-akpata ọrịa ahụ.

  • Enweghị ụkọ nri micronutrient
    • na-akpata enweghị ike nke cell ịnọgide na-ahụ ike na ọrụ)
  • Nje Virus na nje bacteria
  • Mmekorita
    • nri ma ọ bụ gburugburu ebe obibi
  • Nsi gburugburu ebe obibi
    • mmetọ, pesticides, heribcide, plastik, ebu
  • Mgbochi microbiome
    • oke ibu nke ụdị na-adịghị mma nke na-emepụta ikike afọ na mbufụt
  • Ihe oriri na-egbu egbu
    • nri ndị America ọkọlọtọ, carbohydrates edoziri nke ukwuu, mmanụ ụlọ ọrụ mmepụta ihe, shuga dị elu na-achịkwaghị achịkwa

Neuroinflammation na-adịghị ala ala bụ nzaghachi mgbochi maka otu ma ọ bụ karịa n'ime ụdị mwakpo ndị a. Nzaghachi a na-alụso ọrịa ọgụ na-ebute ọrụ nke mkpụrụ ndụ microglial nke na-emepụta cytokines na-egbuke egbuke, karịsịa, TNF-a na IL-1β, iji wepụ ihe a na-ewere dị ka ihe dị ize ndụ. Mana n'ime nke a, enwere mmebi nke anụ ahụ gbara ya gburugburu site na cytokines ndị a. Ụbụrụ ahụ kwesịrị ịrụzi ya, nke na-esiri ike ịrụzu mgbe ọnya na-adịghị akwụsị akwụsị.

Otu echiche na-adọrọ adọrọ nke mgbaàmà ịda mbà n'obi a na-ahụ na ọrịa bipolar nwere ihe metụtara oge. Enwere ọnụ ọgụgụ dị elu nke mgbaàmà ịda mbà n'obi na ọrịa bipolar n'oge opupu ihe ubi. Otu nnyocha na-adọrọ mmasị chọpụtara na mgbaàmà ịda mbà n'obi jikọtara ya na ọbara serum immunoglobulin immunoglobulin E. A na-eche na n'oge opupu ihe ubi, ka pollen na-arị elu, ihe mgbaàmà nke ịda mbà n'obi na ndị mmadụ bipolar nwere ike ịkawanye njọ n'ihi nzaghachi cytokine pro-inflammatory kpatara site na allergies.

Mmepụta microglial nke cytokines mkpali dị mkpa karịsịa na ọrịa bipolar n'ihi na ha na-enye usoro nkọwa maka mgbaàmà anyị na-ahụ na ọrịa bipolar. Ndị ogbugbo na-ere ọkụ, dị ka cytokines, na-akpụzi mgbasa ozi synapti na ọbụna na-ewepụ njikọ dị n'etiti mkpụrụ ndụ ụbụrụ (usoro a na-emekarị nke a na-akpọ kwachaa nke na-esi n'aka na neuroinflammation na-adịghị ala ala). Mgbanwe ndị a na ụbụrụ na-emebi nlebara anya, ọrụ nchịkwa (atụmatụ, mmụta, ịchịkwa omume na mmetụta mmetụta), na adịghị ike ebe nchekwa. Hippocampus, nke bụ akụkụ nke ụbụrụ nwere ọrụ dị mkpa na nhazi ebe nchekwa, bụ nke neuroinflammation na-emetụta nke ukwuu. Mmepụta cytokines na-akpasu iwe na-akpata ọnwụ mkpụrụ ndụ ụbụrụ akabeghị aka.

Mmụba mmepụta cytokine na-akpasu iwe nwere ọrụ siri ike n'ihi ihe mere anyị ji ahụ na-aga n'ihu na-adịghị arụ ọrụ nke ọma na ndị mmadụ karịa tie na n'ọtụtụ akụkụ nke nha. Imebiga ihe ókè nke mkpụrụ ndụ microglial na-eduga n'ịba ụba nke ọgụgụ isi, na-arụ ọrụ na-aga n'ihu na-akawanye njọ, ọrịa ahụike na-agụnye ọrịa na-adịghị ala ala, na n'ikpeazụ, ọnwụ akabeghị aka na ndị nwere ọrịa bipolar.

Ya mere mbufụt na mbelata nke mbufụt, na-atụ anya idozi isi ihe kpatara mbufụt maka onye ọrịa n'otu n'otu, na-aghọ ihe dị oke mkpa nke itinye aka na njem ha na ahụike.

Kedu ka keto si ebelata mbufụt

Echeghị m na ntinye aka ka mma maka mbufụt dị karịa nri ketogenic. Amaara m na nke ahụ bụ okwu dị elu mana were m. Nri ketogenic na-emepụta ihe a na-akpọ ketones. Ketones bụ ahụ na-egosi, nke pụtara na ha nwere ike ịgwa mkpụrụ ndụ ihe nketa okwu. Ahụla ahụ ketone ka ọ na-agbanyụ mkpụrụ ndụ ihe nketa bụ akụkụ nke ụzọ mkpasu iwe na-adịghị ala ala. Nri ketogenic dị irè na mbufụt a na-eji ha maka ọrịa ogbu na nkwonkwo na ọnọdụ mgbu ndị ọzọ na-adịghị ala ala.

Ma chere otu nkeji, ị nwere ike ịsị, ndị ahụ abụghị ọnọdụ nke mbufụt nke ụbụrụ. Ndị ahụ bụ ọrịa mbufụt n'akụkụ nke mere na ha anaghị agụta. Metụ aka.

Mana anyị maara na nri ketogenic dị mma maka neuroinflammation nke na anyị na-eji ha na mmerụ ahụ ụbụrụ. Mgbe nnukwu mmerụ ahụ ụbụrụ gasịrị, enwere nnukwu mmiri ozuzo cytokine na nzaghachi maka mmerụ ahụ, Nzaghachi a na-emebikarị karịa mwakpo mbụ. Nri ketogenic dị jụụ na nzaghachi ahụ Ọ bụrụ na nri ketogenic nwere ike imezi mmerụ ahụ ụbụrụ neuroinflammation, ahụghị m ihe kpatara na ọ gaghị abụ nhọrọ kpakpando maka ọrịa bipolar. Anyị na-ejikwa ya maka ọtụtụ ọrịa neurodegenerative dị ka Alzheimer, ọrịa Parkinson, na ALS. Ọnọdụ niile nwere akụkụ neuroinflammation dị oke mkpa.

Yabụ kedu ihe kpatara na anyị agaghị eji nri ketogenic emebere nke ọma, mgbochi mkpali iji gwọọ usoro mkpali dị n'okpuru anyị na-ahụ na ọrịa bipolar?

Ọrịa Bipolar na Nchegbu Oxidative

Nchegbu oxidative bụ ihe na-eme mgbe enwere ọtụtụ ụdị oxygen na-emeghachi omume (ROS). ROS na-eme n'agbanyeghị ihe anyị na-eme. Mana ahụ anyị maara ihe anyị ga-eme maka ya. Ọbụna anyị nwere usoro antioxidant endogenous (mere n'ime ahụ anyị) na-enyere anyị aka ịnagide ha ma belata mmebi nke ịdị ndụ na iku ume, na iri nri. Mana n'ime ndị nwere ọrịa bipolar, sistemu antioxidant ndị a anaghị arụ ọrụ nke ọma ma ọ bụ enweghị ike ijigide mmebi ahụ na-aga. Ya mere, n'ime ndị nwere ọrịa bipolar, ihe nrịbama nrụgide oxidative na-adị elu karịa njikwa nkịtị na akwụkwọ nyocha. Ọ bụghị naanị otu ihe nrịbama dị elu karịa; ọ bụ ọtụtụ n'ime ha.

Nchegbu oxidative, na enweghị ahụ ahụ enweghị ike ịkwụsị nke ọma neuroinflammation, na-ahụ maka ịka nká hippocampal nke a tụrụ aro ka ọ na-akpata nrụrụ neurocognitive nke a na-ahụ na ndị ọrịa BD. Nchegbu Oxidative na-ebute ịka nká nke ụbụrụ na BD na ọ bụ ọbụna na-ahụ maka mmụgharị DNA dị elu nke mitochondrial (batrị cell) nke a hụrụ na nchọpụta ọnwụ ọnwụ.

Mana naanị inye ndị nwere ọrịa ahụ ọgwụ antioxidant iji belata nrụgide oxidative arụpụtala ihe agwakọtara, ndị nyocha kwenyere na nke a nwere ike ịbụ n'ihi na arụrụ ọrụ mitochondrial na-emetụta ọkwa nrụgide oxidative. Cheta ihe anyị mụtara gbasara ụbụrụ hypometabolism na ụkọ ume na arụrụ ọrụ mitochondrial anyị na-ahụ na ọrịa bipolar? Ọrịa bipolar bụ ọrịa metabolic nke ụbụrụ, ma ọ nweghị ike zuru oke maka ụbụrụ iji mee ihe?

Otu okwu ahụ nwere ike bụrụ ihe kpatara ọkwa nrụgide oxidative nke ndị nyocha hụrụ. Opekempe n'akụkụ ụfọdụ nke ndị nwere nsogbu bipolar na nrụgide oxidative.

N'agbanyeghị ma ọ bụ isi ihe na-akpata ma ọ bụ usoro nke abụọ nke pathology na ọrịa bipolar, anyị maara na nrụgide oxidative na-enyere aka ịmepụta mgbaàmà anyị na-ahụ na ọrịa bipolar. Maka nke ahụ, anyị chọrọ ntinye aka nke na-ebelata nrụgide oxidative ozugbo, ọkachamma site na ọtụtụ usoro.

Kedu ka keto si ebelata nchekasị oxidative

Sistemụ ọkacha mmasị m bụ sistemụ antioxidant endogenous bụ glutathione. Nke a bụ usoro antioxidant siri ike nke na-edozi nri ketogenic n'ezie. Nkwalite a na glutathione na-enyere gị aka ibelata nrụgide oxidative, ma nwee ike melite ọrụ na ahụike nke ụbụrụ bipolar. Nri oriri na-edozi ahụ nke ọma nke na-eme site na nri ketogenic emebere nke ọma na-emekwa ka mmepụta glutathione dịkwuo mma. Ya mere agbakwunyere ego.

Achọpụtara ụdị ketones abụọ - β-hydroxybutyrate na acetoacetate - iji belata ọkwa ROS na mitochondria neocortical dịpụrụ adịpụ (Maalouf et al., 2007)

Achọrọ nyocha ọzọ iji chọpụta kpọmkwem usoro KD na nrụgide oxidative site na mmetụta na ọkwa ROS na antioxidant. O yikarịrị ka a na-enweta mmetụta mgbochi mkpali nke ahụ ketone site na-emetụta ọtụtụ ụzọ biochemical.

Yu, B., Ozveren, R., & Dalai, SS (2021). Nri ketogenic dị ka ọgwụgwọ metabolic maka ọrịa bipolar: mmepe ụlọ ọgwụ.
DOI: 10.21203 / rs.3.rs-334453 / v2

Dị ka nhota ahụ na-ekwurịta nke ọma, nri ketogenic na-emetụta ọtụtụ ụzọ na-agbanwe nrụgide oxidative. E wezụga ahụ ketone, ahụike neuronal emelitere nke na-eme na nri ketogenic, dị ka ịba ụba BDNF, neurotransmitters ziri ezi nke na-adịghị akpata mmebi neuronal (m na-ele gị, glutamate na dopamine!) so n'ibelata nrụgide oxidative. Nke ahụ mere ka ikike na ọrụ dịkwuo mma, yana nri na-edozi ahụ nke ọma site na nri ketogenic emebere nke ọma, na-eme ka enzyme na mmepụta neurotransmitter dịkwuo mma, nke na-ekere òkè n'ịlụso nrụgide oxidative ọgụ.

Ma ị maralarị ma ghọta na nri ketogenic na-akwalite mmepụta nke mitochondria, na-eme ka ọrụ ha dịkwuo mma, ma na-agbakwa sel ụbụrụ ume ime ọtụtụ n'ime ha. Cheekwa etu mkpụrụ ndụ ụbụrụ nwere ike isi jikwaa ROS ka ọ na-eji ọtụtụ obere ụlọ ọrụ ike na-eku ume na-eme ka ike. Nke a nwere ike ịbụ usoro nke nrụgide oxidate nwere ike ibelata nke ukwuu na ụbụrụ bipolar.

mmechi

Ugbu a ị mụtala mmetụta dị ike nke nri ketogenic na ụbụrụ hypometabolism, nguzozi neurotransmitter, mbufụt, na nrụgide oxidative, m ga-ahapụ gị n'okwu a na-atụle echiche dị ugbu a na usoro ọrịa anyị na-ahụ na ọrịa bipolar.

A pathophysiological hypothesis nke ọrịa na-atụ aro taht dysfunctions na intracellular biochemical cascades, oxidative stress na mitochondrial dysfunction mebie usoro njikọ na neuronal plasticity, na-eduga cell mebiri na n'ihi ọnwụ nke ụbụrụ anụ ahụ nke achọpụtara na postmortem na neuroimaging.

Young, AH, & Juruena, MF (2020). Neurobiology nke Ọrịa Bipolar. N'ime Ọrịa Bipolar: Site na Neuroscience ruo Ọgwụgwọ (p. 1-20). Mmiri, Cham. https://link.springer.com/chapter/10.1007%2F7854_2020_179

N'oge a, enwere m obi ike na ị nwere ike ịme njikọ ndị ahụ ma nwee nghọta ka mma otú nri ketogenic nwere ike isi bụrụ ọgwụgwọ siri ike maka ọrịa bipolar gị ma ọ bụ nke onye ị hụrụ n'anya.


M ga-atụ egwu ide blọgụ a afọ ole na ole gara aga, n'agbanyeghị na enwere ọtụtụ akụkọ anecdotal na-apụta site na ndị mmadụ na-akọ na-emeziwanye ihe mgbaàmà na arụ ọrụ. Obi dị m ụtọ ịhụ ka a na-eme nyocha dị ukwuu.

Ihe mere m ji enwekwu obi ike n'ịde blọgụ blọgụ dị ka nke a bụ na enwere ọmụmụ ihe nyocha nke ndị ọgbọ na-egosi mgbaghara nke mgbaàmà bipolar site na iji nri ketogenic na RCT na-aga n'ihu na-ele anya na nri ketogenic dị ka ọgwụgwọ maka ọrịa bipolar. Enwere ọbụna ọrụ nke ndị nchọpụta na-enyocha na nkwupụta na forums ebe ndị nwere nsogbu bipolar na-ekwurịta iji nri ketogenic iji mee ka ahụ dịkwuo mma (lee. Ketosis na ọrịa bipolar: nyocha nyocha nke a na-achịkwa nke akụkọ ntanetị).

Enwere okpokoro mara mma (Table 1) n'akwụkwọ akụkọ Nri ketogenic dị ka ọgwụgwọ metabolic maka ọrịa bipolar: mmepe ụlọ ọgwụ nke na-akọwapụta nke ọma usoro nri ketogenic nwere ike isi nyere aka ịgwọ ọrịa bipolar. Ebe ọ bụ na ị ka wepụtara oge gụọ akụkọ a, ị ga-aghọta nke ọma ihe tebụl a na-ekwurịta okwu! Emeghachiri m ya ebe a:

Usoro BDMgbaàmà BDMmetụta KD nwere ike ime
Mitochondrial adịghị arụ ọrụMbelata mmepụta ọkwa umeNa-akpali mitochondrial biogenesis
Na/K
ATPase ọnwụ nke ọrụ
Mmepụta ATP adịghị mma site na Oxidative phosphorylationna-enye ụzọ mmepụta ike ọzọ site na ketosis
PDC adịghị arụ ọrụỌkwa ATP na-adịghị adịgide adịgide n'ihi mmepụta glycolysis naanịNa-enye ụzọ mmepụta ike ọzọ site na ketosis
Nsogbu OxidativeMmụba na ROS na-eduga na mmebi neuronalNa-ebelata ọkwa ROS na ahụ ketone; Na-abawanye ọkwa cholesterol HDL maka mgbochi neuroprotection
Ọrụ MonoaminergicMgbanwe na omume na mmetụta uche n'ihi mkpokọta neurotransmitter na-ezighi eziNa-achịkwa metabolites neurotransmitter site na ahụ ketone na etiti
dopamineMmụba na ịgbalite nnabata na-ebute akara maniaNa-ebelata metabolites dopamine
SerotoninMbelata ọkwa na-ebute mgbaàmà ịda mbà n'obiNa-ebelata metabolites nke serotonin
NorepinephrineMbelata ọkwa na-ebute mgbaàmà ịda mbà n'obiEnweghị mgbanwe dị ịrịba ama a hụrụ na ọmụmụ ihe mbụ
GebaMbelata ọkwa nke metụtara ịda mbà n'obi na mgbaama maniaNa-abawanye ọkwa GABA
GlutamateMmụba na ọkwa nke na-eduga n'ịchọ ike na-adịghị adịgide adịgide yana mmebi neuronalNa-ebelata ọkwa glutamate
GSK-3 Enzyme adịghị arụ ọrụ / erughi eruApoptosis na mmebi neuronalNa-abawanye antioxidants iji nye neuroprotection
(Isiokwu 1) n'akwụkwọ akụkọ Nri ketogenic dị ka ọgwụgwọ metabolic maka ọrịa bipolar: mmepe ụlọ ọgwụ

Ọ bụrụ na ịchọtara blọọgụ a na-enyere aka ma ọ bụ na-adọrọ mmasị, ị nwekwara ike ịnụ ụtọ ịmụta ka nri ketogenic nwere ike isi rụọ ọrụ n'ịgbanwe mkpụrụ ndụ ihe nketa.

Ọ bụrụ na ị nwere comorbidities na nsogbu ndị ọzọ, ị nwere ike ịhụ na ọ na-enyere gị aka ịchọ nke m blog (Ogwe ọchụchọ na ala nke ibe na desktọpụ) wee hụ ma nri ketogenic nwere mmetụta bara uru na usoro ọrịa ahụ. Ụfọdụ n'ime ndị a ma ama nke nwere ike ịdị mkpa na ọrịa bipolar gụnyere:

Dị ka onye na-ahụ maka ahụike uche nke na-enyere ndị mmadụ aka ịgafe nri ketogenic maka ahụike uche na nsogbu akwara ozi, enwere m ike ịgwa gị na m na-ahụ ọganihu ọtụtụ mgbe na ndị nwere ike iji nri ketogenic mgbe niile. Nke ahụ bụkwa ọtụtụ ndị ọrịa m. Ọ bụghị ọgwụgwọ na-adịghị adịgide adịgide maka ọrịa bipolar ma ọ bụ nke ọ bụla n'ime nsogbu ndị ọzọ m na-emeso site na iji nri ketogenic, psychotherapy, na ihe oriri ndị ọzọ ma ọ bụ ọrụ isi mgbaka.

Ị nwere ike ịnụ ụtọ ịgụ obere ihe nlele m nke Ọmụmụ Ihe Ebe a. Maka ụfọdụ ndị ahịa m, ọ bụ maka ịnwale ihe na-abụghị ọgwụ iji gwọọ ọrịa bipolar ha. Maka ọtụtụ, ọ bụ maka ibelata mgbaàmà prodromal ha na-aga n'ihu na-ebi ndụ, ọtụtụ na-anọkwa na otu ọgwụ ma ọ bụ karịa. Ọtụtụ mgbe na obere dose.

Ị nwekwara ike ịnụ ụtọ posts ndị ọzọ gbasara ọrịa bipolar na iji nri ketogenic ebe a:

Ọ bụrụ na ị ga-achọ ịkpọtụrụ m ị nwere ike ime ya Ebe a. Enwere m obi ụtọ inyere gị aka ịchọta akụrụngwa ma ọ bụ duzie gị na njem ahụike gị mgbe ị na-ahazi onye na-ede akwụkwọ gị. Atụrụ m anya na akụkọ a enyerela gị aka n'ikike gị ịmara ụzọ niile ị ga-esi nwee mmetụta ka mma!

Dị ka ihe ị na-agụ na blọgụ? Chọrọ ịmụta maka webinars na-abịa, nkuzi na ọbụna na-enye nkwado na iso m na-arụkọ ọrụ maka ebumnuche ọdịmma gị? debanye aha!


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