ọgwụgwọ maka TBI na PTSD

Ọgwụgwọ maka TBI na PTSD

Nri ketogenic ọ nwere ike ịgwọ mmerụ ahụ ụbụrụ ụbụrụ (TBI) na nsogbu nrụgide post-traumatic (PTSD) n'otu oge?

ọgwụgwọ maka TBI na PTSD

Nri ketogenic nwere ike ịbụ ọgwụgwọ dị mma maka ndị mmadụ na-ata ahụhụ ma TBI na PTSD n'ihi ike ya ịgbanwe usoro usoro ọgwụgwọ ọrịa na-akpata na nsogbu abụọ ahụ. Nri Ketogenic na-ebelata neuroinflammation na nrụgide oxidative, nguzozi neurotransmitter hyperexcitability, kwalite ume ụbụrụ na metabolism, na ịkwalite ọkwa nke ụbụrụ neurotrophic kpatara (BDNF). Nri ketogenic na-arụkwa mmetụta neuroprotective nke nwere ike ibelata ọkwa nke mmebi neurodegenerative na-esote nke a hụrụ na ndị nwere otu ma ọ bụ abụọ nsogbu.

Tebulu ọdịnaya

Okwu Mmalite

Na blọgụ blọgụ a, m ga-ekwu maka otu isiokwu nyocha. 

Monsour, M., Ebedes, D., & Borlongan, CV (2022). Nyochaa pathology na ọgwụgwọ nke TBI na PTSD. Ọrịa Neurology, 114009. https://doi.org/10.1016/j.expneurol.2022.114009

N'ime isiokwu nyocha, ndị edemede ahụ rụrụ ọrụ magburu onwe ya nke na-egosi njikọ dị n'okpuru pathophysiology anyị na-ahụ na ụbụrụ ndị nwere TBI na / ma ọ bụ PTSD. Ọ bụ akụkọ mara mma, IMHO na-eme nyocha nke ọma nke akwụkwọ. Ọgba aghara m malitere mgbe m chọpụtara na ọ bụ ezie na ndị nchọpụta a chọpụtara ọrịa ndị na-akpata ọrịa na ọgwụgwọ ndị a na-ejikarị eme ihe ugbu a na ọgwụgwọ ndị nwere ike ime n'ọdịnihu, a naghị etinye nri ketogenic.

Nke a tụrụ m n'anya nke ukwuu. Ya mere, atụmatụ m bụ ide blọgụ blọgụ a na-ezo aka ozugbo na nyocha ha nke na-achọpụta pathologies dị na TBI na PTSD ma kwurịta otú nri ketogenic si emetụta otu usoro ahụ mgbe ọ na-adọta site na akwụkwọ nyocha iji mee ka ikpe m mee.

M ga-ekekọrịta a blọọgụ post na ndị na-agụ akwụkwọ wee hụ ihe ha chere.

O nwere ike ịbụ na nri ketogenic anọghị na radar ha dịka ọgwụgwọ nwere ike. Ma ọ bụ ma eleghị anya, ozughị ụfọdụ ụdị njirisi ha nwere maka nsonye ya. Mana ndị nchọpụta a enweghị mmasị na-asọmpi nke ga-eme ka m chee na ha agaghị achọ ịma banyere ya ma na-emeghe ka a tụlee ya. Ma eleghị anya, ọ bụrụ na anyị ekerịta ihe anyị maara, ha ga-adị njikere ịtụle ya n’akwụkwọ a ga-ebipụta n’ọdịnihu.

Ma, ka anyị buru ụzọ kwuo banyere nsogbu abụọ a.

Ọrịa ụbụrụ na-akpata mmerụ ahụ (TBI) na mmerụ ahụ ụbụrụ post-traumatic na nyocha abụọ dị iche iche nke a na-ahụkarị ọnụ na ọnụ ọgụgụ dị iche iche mana a na-ahụ ya na-emekọ ọnụ na ndị na-arụ ọrụ agha na mba ofesi, ndị ihe ike mere n'ụlọ, na ihe mberede anụ ahụ nke a. mmerụ isi emela.


A na-akọwakarị TBI dị ka mmerụ ahụ ụbụrụ n'ihi ike dị n'èzí ma nwee ike ịdị site na nwayọọ ruo na nke siri ike. Mgbaàmà nwere ike ịgụnye isi ọwụwa, isi ọwụwa, tinnitus, na mgbaama mgbaama. Mgbaàmà nke ọgụgụ isi nwere ike ịgụnye mgbanwe okwu, itinye uche, na adịghị ike ebe nchekwa. Ndị nwere mmerụ ahụ nke TBI siri ike nwekwara ike ịnwe ọnya ụbụrụ (mgbasa ahụ), mbufụt na-adịghị ala ala, na ọrịa ndị ọzọ a na-ahụ anya.

Kedu ka TBI na PTSD si yie?

Ọtụtụ ndị zụlitere PTSD enwewo mmerụ ahụ nke butere mmerụ ahụ TBI. Ọ bụ ezie na njikọ njikọ a bụ ma ezi uche ziri ezi ma gosipụta ya na nyocha, myirịta anaghị akwụsị ebe ahụ. Ha abụọ nwere ma mkpesa akwara ozi na nke mmụọ, nke gụnyere:

  • nchegbu
  • mgbakasị
  • ehighị ụra nke ọma
  • cognition mmebi

Ọ bụghị ihe mgbagwoju anya, ndị na-agbaso ụkpụrụ maka PTSD na TBI na-enwe mmetụta na-adịghị mma na-enweghị ọgwụgwọ dị irè.

A na-eme ka ọnọdụ abụọ a dịgide site na usoro dị n'okpuru nke neuroinflammation, nrụgide oxidative, adịghị mma neurotransmitter excitotoxic, na, ọ bụghị ihe ijuanya, mgbanwe na nhazi ụbụrụ.

Usoro ndị a dị n'okpuru anaghị eme naanị otu ugboro n'oge mmerụ anụ ahụ ma ọ bụ mmetụta uche wee kwụsị. Usoro ndị a na-ejighị n'aka na-enye aka na ịka nká nke neurodegenerative, na-eme ka mmebi na mgbaàmà na-aga n'ihu. Ọ bụghị echiche na-enweghị ezi uche na myirịta dị na mgbaàmà ndị a na-ahụ n'etiti ọnọdụ abụọ a bụ n'ihi nnukwu nchikota n'ime usoro nke pathology.

N'ime isiokwu nyocha a kpọtụrụ aha n'elu, ndị edemede na-atụle nhọrọ ọgwụgwọ ugbu a maka nsogbu ndị ahụ. Ụfọdụ n'ime ndị dị mkpa na arụmụka anyị bụ usoro cell stem cell exogenous, Hyperbaric Oxygen Therapy (HBOT), na ọgwụ. Ihe oriri ketogenic kwesịrị ịgụnye n'isiokwu a site n'aka ndị edemede dịka ọgwụgwọ ọzọ maka TBI na PTSD.

Gịnị kpatara? N'ihi ihe ndị a:

  • Stems cell na-akpa ike. Usoro mmegide nwere ihe egwu. Mkpụrụ ndụ azuokokoosisi bụ enyemaka ahụike dị oke ọnụ.
  • Ọ bụghị onye ọ bụla nwere PTSD na TBI nwere ike ịnweta HBOT n'ụlọ ọgwụ ndị agha ma ọ bụ nwee mkpuchi nke ga-ekpuchi ya, ha na-ata ahụhụ ugbu a!
  • Ọ bụrụ na ọgwụ ndị ahụ na-enye aka mgbe nile, anyị agaraghị enwe ọtụtụ nhụjuanya. Mmepe ọgwụ ọhụrụ dị oke ọnụ ma na-ewe oge. Ọzọkwa, ndị mmadụ na-ata ahụhụ ugbu a.
  • A enyochalarị nri ketogenic na akwụkwọ sayensị dị ka ọgwụgwọ nwere ike ime maka TBI, na oku maka RCT ekwenyela na mbipụta nke otu ikpe nke Phase I.
  • Ọmụmụ anụmanụ egosila na ụmụ oke na-ekpughe trauma na-egosipụta cerebellar na ọtụtụ usoro metabolic reprogramming. PTSD na-etolite site na mkpughe trauma, na nri ketogenic bụ ntinye aka nke ụbụrụ maka ụbụrụ.
  • Ihe ọmụmụ ikpe ebipụtara na RCT dị maka ọnụ ọgụgụ ndị ọrịa uche akọwapụtara nke a na-ahụ mgbanwe metabolic dị ka ihe na-akpata ọrịa (dịka, ọrịa Alzheimer, ALS, ọrịa bipolar, nsogbu ịṅụ mmanya na-aba n'anya, na schizophrenia), na-egosi nsonaazụ ọgwụgwọ dị mma.
  • Nri ketogenic chọrọ ntinye aka dị ala karịa usoro ọgwụgwọ stem cell ma ọ bụ ọbụna HBOT, yana ọbụna ọgwụ. Ogologo oge nke ọgwụ bụ atụmanya dị oke ọnụ maka ụlọ ọrụ ịnshọransị na ndị ọrịa. Enwere ike itinye nri Ketogenic n'ụlọ site n'aka onye ọrịa na ezinụlọ ha ma nwee ike ịchọ naanị nkwado oge site n'aka onye na-ahụ maka nri nri ma ọ bụ ụdị ọkachamara nri ketogenic ọzọ.

N'ime blọgụ blọgụ a, anyị ga-atụle usoro nrịanrịa nke achọpụtara n'isiokwu a na ndị mmadụ na-arịa PTSD na/ma ọ bụ TBI. N'iji akwụkwọ ndị dịnụ na mmetụta nke nri ketogenic na usoro ndị ahụ, anyị ga-eme ka ikpe ahụ bụrụ na nri ketogenic kwesịrị ịgụnye na isiokwu nyocha.

Site n'ibisa akụkọ a, anyị ga-anwa inyere ndị nwere PTSD na/ma ọ bụ TBI aka ịmụta ụzọ niile ha nwere ike isi nweta mma.

Kekọrịta Pathophysiology n'etiti TBI na PTSD

Ihe mgbaàmà na-ejikọta ọnụ na njikọta nke TBI na PTSD nwere ike jikọta ya na nnukwu ndakọ dị na pathophysiology dị n'okpuru. Ma nsogbu akwara ozi na-egosi nnukwu neuroinflammation, nrụgide oxidative, excitotoxicity, na mgbanwe nhazi.

Monsour, M., Ebedes, D., & Borlongan, CV (2022). Nyochaa pathology na ọgwụgwọ nke TBI na PTSD. Neurology nnwale, 114009. https://doi.org/10.1016/j.expneurol.2022.114009

Neuroinflammation

Otu n'ime ihe ndị na-emebi emebi na-eme na TBI bụ neuroinflammation. Ntọhapụ nke cytokines proinflammatory dị ka IL-1, IL-12, TNF-α, na IFN-γ na-ewepụta site na ọrụ sistemu sistemu na ụbụrụ. A na-eme usoro ahụ ji alụso ọrịa ọgụ na nzaghachi maka mwakpo anụ ahụ (ma ọ bụ nke mmetụta uche) nke merela. Ọrụ a na-abawanye mkpụrụ ndụ na-alụso ọrịa ọgụ na ụbụrụ a na-akpọ microglia. Ha na-emepụta nnukwu ọzịza nke mbufụt ma na-akwalite okirikiri neuroinflammatory na-adịghị ala ala. Ndị a neuroinflammatory cycles na-eduga n'ihu mmebi cell na ọnwụ neuronal. Ka neurons na-emerụ ahụ karị ma na-anwụ anwụ, ha na-ahapụ ndị neurotransmitters na-akpali akpali dị ka glutamate, nke na-akwalite ahaghị nhata nke neurotransmitter. Mmebi nke mgbochi ụbụrụ ọbara (BBB) ​​na-eme n'ihi ntọhapụ cytokine ọzọ site na astrocytes. Nke a na-emebi ihe mgbochi nke ọbara-ụbụrụ na-eme ka usoro ahụ ji alụso ọrịa ọgụ neuronal na-emeghachi omume na usoro mkpali. Na-eme ka gburugburu ebe obibi neurotoxic karịrị nke mbụ anụ ahụ ma ọ bụ nke mmetụta uche nke TBI na/ma ọ bụ PTSD.

PTSD nwere nzaghachi neuroinflammation yiri nke ahụ na TBI. Ha abụọ na-egosi ụbara cytokines pro-inflammatory, mana ntọhapụ na-abawanye na-abịa mgbe ihe omume na-akpata nchekasị kama mmerụ ụbụrụ anụ ahụ, dị ka a hụrụ na TBI. Ma TBI na PTSD nwere ike igosi ọrụ microglia na-adịghị ala ala ọtụtụ iri afọ ka e mesịrị, na-emepụta mmebi ọzọ na neurons maka oge niile ha na-arụ ọrụ.

Nri ketogenic bụ ezigbo modulators nke neuroinflammation. A na-edekọ mmetụta nke ọma nke ọma, karịsịa n'iji ya eme ihe maka ọrịa akwụkwụ na-eguzogide ọgwụgwọ. A na-eche na nri ketogenic na-agbanwe neuroinflammation site na ọtụtụ usoro dị iche iche, nke nwere ike ịgụnye mgbanwe nke microbiome gut, mbelata ọkwa shuga dị n'ọbara nke na-eme ka mbufụt, na ahụ ketone n'onwe ya.

Ketones na-arụ ọrụ dị ka molekul na-egosi akara nke na-agbanwe mkpụrụ ndụ ihe nketa na-etinye aka na ụzọ mkpali na-adịghị ala ala. Ọtụtụ ọmụmụ egosila na otu ụdị ketone, nke a maara dị ka β-hydroxybutyrate (BHB) nwere mmetụta na ndị na-anabata ya na-achịkwa ọrụ na ntọhapụ nke cytokines pro-inflammatory dị ka IL-1β na IL-18.

A hụla otu ahụ ketone ndị a ka ọ na-enwe mmetụta bara uru na mgbochi ụbụrụ ọbara (BBB) ​​ịrụ ọrụ na nrụzi. A na-eche na nke a na-eme n'ihi ume ka mma na astrocytes nke nwere ike ịrụzi ma na-edozi ihe mgbochi ụbụrụ ọbara (BBB) ​​ya mere na-ebelata ụmụ irighiri ihe na-esi na ya na-abata site na sistemu sistem. Nke a nwere ike ịbụ ihe dị mkpa nke nwere ohere dị mma nke ibelata nzaghachi neuroinflammatory na-adịghị ala ala anyị na-ahụ post-TBI na PTSD.

Mmetụta nke ketones iji gbanwee mbufụt ka egosiri na vitro na na vivo. Kedu ihe kpatara na nke a agaghị abụ usoro ọgwụgwọ bụ isi, nke akọwapụtara na akwụkwọ sayensị iji nyere aka na-agwọ ọrịa na-akpata ọrịa na TBI na PTSD, bụ nnọọ ihe karịrị m. Enweghị m ike ịchọpụta ihe kpatara na etinyeghị ya na nyocha a magburu onwe ya sitere n'aka ndị ode akwụkwọ.

Mana ka anyị gaa n'ihu na-eleba anya na pathology dị n'okpuru wee hụ ihe ọzọ nri ketogenic nwere ike ime maka ndị nwere TBI na PTSD.

oxidative nchegbu

Ozugbo ị nwetara nzaghachi na-adịghị ala ala nke na-adịghị ala ala n'ụbụrụ site na iji ọrụ microglial ahụ niile, ị na-ewuli ihe a na-akpọ nrụgide oxidative. Nchegbu oxidative na-eme mgbe ihe ndị a chọrọ maka nrụzi cell karịrị ihe antioxidant dị n'ime gị na sistemụ micronutrient nwere ike ijikwa. Mgbochi cell na-akwụsị ịrụ ọrụ nke ọma, ụlọ ahịa micronutrients na-agwụ ike, mkpụrụ ndụ na-adakwa mbà n'ihi na ha enweghị ike zuru ezu iji rụkwaa ya, hapụ ọkụ, ma rụọ ọrụ nke ọma. Ha na-anwụ, na-akpaghasịkwa nguzozi neurotransmitter dị nso na sel ndị gbara ha gburugburu mgbe ha na-aga. Nchegbu oxidative na-eme ka neurocognitive ịka nká ngwa ngwa karịa ka ọ gaara eme.

Ndị nwere TBI na PTSD nwere oke nrụgide oxidative. Ọ na-esikwa ike ịkọwa ọkwa nke nrụgide oxidative na-akpaghasị ọrụ ụbụrụ nkịtị. Ma ndị na-ede akwụkwọ na-arụ ọrụ mara mma nke na-eme ka ọ pụta ìhè na ntinye okwu na-esonụ site na isiokwu ahụ.

Na TBI, PTSD, na
ọnọdụ jikọtara ọnụ, ụdị mmeghachi omume na-eduga n'ihu BBB permeability,
gbanwee neuronal plasticity, imebi neurotransmission, na mgbanwe
neuronal morphology na ndị agha agha na ụdị anụmanụ

Monsour, M., Ebedes, D., & Borlongan, CV (2022). Nyochaa pathology na ọgwụgwọ nke TBI na PTSD. Neurology nnwale, 114009. https://doi.org/10.1016/j.expneurol.2022.114009

Yabụ kedu ihe nri ketogenic ga-enye oke nrụgide oxidative? Ọtụtụ, n'ezie. Nri ketogenic, na ketones nri ndị ahụ na-emepụta, na-emeso nrụgide oxidative n'ọtụtụ ụzọ. Nke mbụ, ha na-emeziwanye ike cell ka nrụzi na sel na nlekọta nwere ike ime. Ike a emelitere na-enyekwara cell aka ịrụ ọrụ nke ọma. Ike cell na-emewanyewanye nke sitere na ketones na-enye ohere ka akpụkpọ ahụ sel rụọ ọrụ nke ọma, nke pụtara na ọ nwere ike ịchekwa nri ndị dị mkpa maka ịmepụta ndị na-emekọ ihe dị mkpa na nlekota cell na ịmepụta neurotransmitter. Ya mere, na nri ketogenic, anyị na-eme ka ike na ahụike nke mkpụrụ ndụ dịkwuo mma n'ụzọ na enwere mmetụta neuroprotective dị ukwuu nke nrụgide oxidative.

Ihe ọzọ ketone na-eme nke na-emetụta ọkwa nrụgide oxidative ozugbo na ụbụrụ bụ nhazi nke antioxidants endogenous, dị ka glutathione. Glutathione bụ onye na-ekpochapụ ụdị oxygen na-emeghachi omume, nke quat na-apụ n'anya mgbe ụbụrụ na-ejupụta na nrụgide oxidative. Ọ bụrụ na ị nwere TBI na/ma ọ bụ PTSD, ị gaghị achọ ka emeziwanye ihe mgbochi mkpali nke endogenous kacha ike ma na-arụ ọrụ zuru oke?

Nsonaazụ ndị a na-ekwusi ike na ketones na-emeziwanye metabolism nke ụbụrụ ụbụrụ post-TBI site na ịnye ihe ndị ọzọ na site na njirimara antioxidant, na-egbochi nrụgide oxidative-mgbasaa mitochondrial dysfunction.

Greco, T., Glenn, TC, Hovda, DA, & Prins, ML (2016). Nri ketogenic na-ebelata nrụgide oxidative ma kwalite ọrụ mgbagwoju anya nke mitochondrial. Akwụkwọ nke Ọrịa Ọbara Ọkụ & Metabolism, 36(9), 1603-1613. https://doi.org/10.1177/0271678X15610584

N'ezie, enweela ọmarịcha nyocha nke na-eji nri ketogenic dị ka ọgwụgwọ maka TBI. Ya mere, aghọtaghị m ihe kpatara na ndị edemede, bụ ndị na-arụrịta ụka na e nwere ihe jikọrọ ya na pathology, agaghị ekwu ya dị ka nhọrọ ọgwụgwọ nwere ike ime maka ndị na-arịa otu ma ọ bụ abụọ nsogbu.

Excitotoxicity, aka neurotransmitter erughị ala

Ya mere, neuroinflammation niile na-ebelata ikike nke mkpụrụ ndụ ịrụzi. Ma mgbe nguzozi ahụ n'etiti nrụzi na mmebi na-apụ n'anya, ị nwere oke nrụgide oxidative. Na ọkwa dị elu nke nrụgide oxidative na-eme ihe abụọ dị iche iche nye ndị na-ahụ maka neurotransmitters. Ya mere, ọ bụghị ihe ijuanya na na TBI na PTSD, anyị na-ahụ excitability na akụkụ cortical na hippocampus nke ụbụrụ nke a na-eche na ọ bụ n'ihi ụbara mmepụta glutamate. Ekwesịrị inwe ego zuru oke nke neurotransmitter inhibitory akpọrọ GABA nke kwesịrị idobe usoro a n'ụzọ ziri ezi. Ma mgbe gburugburu ebe ụbụrụ gị na-agbalị ime neurotransmitters jupụtara na nrụgide oxidative na mbufụt, ọ naghị edozi neurotransmitters ndị a.

N'ụdị anụmanụ nke PTSD na TBI jikọtara ọnụ, anyị na-ahụ mgbanwe n'ikike ụbụrụ ịmegharị neurotransmitters abụọ a. Enwere glutamate dị ukwuu yana ezughị GABA na nha kwesịrị ekwesị ma ọ bụ na-anọpụ n'ebe kwesịrị ekwesị. Nke a na-adịghị ahụkebe neurotransmitter nwere ike imebi njikwa na cortex n'ihu, nke kwesịrị ịrụ ọrụ iji mee atụmatụ omume, mezie mmetụta uche, na ime ọtụtụ ọrụ ndị ọzọ dị mkpa anyị na-ahụkarị na-adịghị mma na ndị nwere TBI na / ma ọ bụ PTSD.

Ya mere ọzọ, enwere m mgbagwoju anya maka ihe kpatara ya, ọ bụrụ na enwere nkwụsịtụ na usoro glutamate / GABA na ndị nwere TBI na PTSD, ndị na-ede akwụkwọ agaghị abụ abụ uru dị na nri ketogenic.

A na-edepụta mmetụta nke nri ketogenic na usoro glutamate/GABA nke ọma, ọzọ na akwụkwọ akụkọ gbasara ọrịa akwụkwụ na-eguzogide ọgwụgwọ. Mweghachi nke neurotransmitter GABA nke na-eme na nri ketogenic ka echepụtawo dị ka ikekwe otu n'ime usoro dị n'okpuru nke mbelata ọdịdọ na ndị a.

Ụzọ ọzọ a na-ahụta nri ketogenic iji meziwanye nguzozi nke neurotransmitter ma belata hyperexcitability bụ n'ikike ya iji meziwanye ọrụ akpụkpọ anụ neuronal. Nke a nwere mmetụta kpọmkwem na ọwa calcium ion, ugboro ole ha na-agba ọkụ na otú ha si akpali akpali. A kọwakwara nke a dị ka usoro nke nri ketogenic na-enyere aka ibelata oge njide na ọnụ ọgụgụ ndị Akwụkwụ na-adọ.

Ya mere ọzọ, na nri ketogenic nwere mmetụta ndekọ nke ọma na ọrụ neurotransmitter na ọrụ akpụkpọ anụ neuronal, ejighị m n'aka ihe kpatara na ejighị ya ma ọ bụ kwurịta ya dị ka ọgwụgwọ nwere ike maka TBI na PTSD.

Ọdịdị ụbụrụ ụbụrụ

N'ọgba aghara ọ bụla nke nwere neuroinflammation na-adịghị ala ala, ọkwa dị elu nke nrụgide oxidative, na nkwụsị nke neurotransmitter, ị ga-ahụ mgbanwe n'ezie na akụkụ anụ ahụ nke ụbụrụ. Akụkụ ụfọdụ ga-ebuwanye ibu ma ọ bụ dị ntakịrị, na akụkụ ụfọdụ ga-ejikọta na akụkụ ndị ọzọ n'ụzọ na-adịghị mma. Ahụ ike nke neuron gị bụ ihe ndabere maka ịrụ ọrụ nke ihe ndị ahụ niile. N'ime ndị nwere TBI, mgbanwe ndị a na-akpaghasị anya na njikọ dị n'etiti akụkụ ụbụrụ nwere ike ịdịgide site na ịkpụ axonal nke mere dị ka akụkụ nke mmerụ ahụ.

Ya mere, ọ bụghị ihe ijuanya na ndị edemede na-aga n'ihu na-ekwu maka mgbanwe ụbụrụ a na-ahụ na ndị na-arịa TBI na PTSD. Ndị nchọpụta achọpụtala mgbanwe dị ukwuu na nhazi ụbụrụ yana njikọ n'etiti ndị nwere TBI na PTSD.

Ihe na-adịghị mma nke fronto-cingulo-parietal cognitive network network, nke na-etinye aka na cognition, ebe nchekwa, nlebara anya, na mgbochi nke nhazi egwu dị mkpa iji ghọta pathology nke TBI na PTSD.

Monsour, M., Ebedes, D., & Borlongan, CV (2022). Nyochaa pathology na ọgwụgwọ nke TBI na PTSD. Neurology nnwale, 114009. https://doi.org/10.1016/j.expneurol.2022.114009

Ndị ọrịa nwere PTSD na TBI na-egosipụta mgbanwe ndị yiri ya na akụkụ ụbụrụ, nke a na-eche na ọ na-enye aka na mgbaàmà na-ekerịta site na ọnọdụ ụjọ na-adịghị mma, mmetụ mmetụta uche, na igbochi prefrontal cortex metabolism.

Enwere ma ọ dịkarịa ala usoro ihe omume abụọ na nri ketogenic nke nwere ike ịbụ ọgwụgwọ dị irè maka okwu ndị a. Ọ bụ ezie na usoro ndị a tụlere n'ihu nwere ike ime ka ọnọdụ dị na ụbụrụ dịkwuo mma iji belata ohere ma ọ bụ ịdị njọ nke ụbụrụ ụbụrụ ogologo oge site n'ibelata mbufụt na nrụgide oxidative, e nwere ihe ndị ọzọ nke nri ketogenic nke nwere ike inye aka dozie ụbụrụ ụbụrụ na-adịghị mma na nke a. onu ogugu mmadu.

Nke mbụ, nri ketogenic bụ ntinye aka nke metabolic. Anyị na-ejibu ha emeziwanye metabolism ụbụrụ na cortex prefrontal, ọkachasị ndị nwere ọrịa Alzheimer. Kedu ihe kpatara na anyị agaghị eji nri ketogenic kwalite ụbụrụ hypometabolism na prefrontal cortex nke ndị nwere TBI na PTSD?

Ketones na-enye isi iyi mmanụ ọkụ dị ngwa ngwa nke na-emeziwanye ngwa ngwa wee ghọọ ume site na mkpụrụ ndụ ụbụrụ. Mmanụ ụgbọala ahụ na-abanye n'ebe ahụ, ọ dịghị mkpa ka ị na-emeso ndị na-ebugharị agbajiri agbaji ma ọ bụ ndị nwere nsogbu nke nwere ike bụrụ ihe mgbochi na ụbụrụ na TBI na PTSD.

Ketones na-achịkwa metabolism nke ụbụrụ, ọ bụghị naanị site n'inye mmanụ mmanụ ọzọ kama site n'ịbawanye ọnụọgụ na ahụike nke mitochondria n'ụzọ nkịtị. Mitochondria bụ batrị nke sel gị. Ọ bụrụ na ịchọrọ karịa ume cell na iji ike cell mee ihe nke ọma, ị ga-achọ nnukwu ahụike na arụ ọrụ mitochondria. Nkwalite na ọnụọgụ na ọrụ nke mitochondria maka ụbụrụ TBI na PTSD bụ ntinye aka siri ike maka nhazi ụbụrụ hypometabolism. Ịghara imekọ ihe na hypometabolism ga-eduga na mbelata nke lobe ihu ma mee ka njikọ na-adịghị mma na akụkụ ndị ọzọ ka oge na-aga.

Ihe ọzọ ketones na-eme nke ga-enyere aka na ụbụrụ jupụtara na njikọ ezughị oke ma ọ bụ enweghị nsogbu bụ imeziwanye BDNF. BDNF na-anọchi anya ihe ụbụrụ neurotrophic sitere na ụbụrụ, ọ na-enyere aka ịgwọ ụbụrụ ma na-enyere aka n'ịmụ ihe na ebe nchekwa. Ọ na-arụkwa ọrụ dị mkpa na njikọ synapti. Ọ dị mkpa ịmegharị ụbụrụ azụ ka ọ dị? Ị ga-achọ BDNF. A na-enye ọtụtụ n'ime ya na ọtụtụ ume ike site na mitochondrial upregulation ị na-ahụ na nri ketogenic.

Kedu ihe mitochondria na-eme?

mmechi

Ndị na-ede akwụkwọ kwetara na ọ bụ ezie na ọtụtụ ndị ọrịa TBI/PTSD na-enweta ọgwụgwọ ọgwụgwọ, nlekọta dị otú ahụ ezughị ezu iji dozie ihe ndị na-eme ka neurodegeneration na-aga n'ihu na-eme ka ọrịa na-akawanye njọ na ọganihu mgbaàmà.

Ha na-aga n'ihu n'isiokwu ahụ iji kwurịta ọgwụgwọ ndị na-ekwe nkwa ọgwụgwọ dị ka hyperbaric oxygen therapy (HBOT), nke m bụ nnukwu onye ofufe, yana usoro ọgwụgwọ sel. Usoro ọgwụgwọ abụọ a ga-adị ịtụnanya maka ndị nwere TBI na PTSD, ma nwee ezigbo nyocha maka nkwado dịka ọgwụgwọ dị irè. Otú ọ dị, ha dị ntakịrị ọnụ, na ọ bụghị onye ọ bụla nwere ohere zuru oke maka ọgwụgwọ ndị a n'agbanyeghị na anyị ga-achọ ka ha mee ya.

Ya mere, maka ndị na-achọghị ma ọ bụ na-enweghị ike ị nweta usoro neuronal stem cell ma ọ bụ na-enweghị ohere ịnweta hyperbaric oxygen n'ụlọ ọgwụ ndị agha mpaghara ha, achọrọ m ka ị mara na usoro usoro ọgwụgwọ ndị a na-enweta site na iji nri ketogenic. BHB, ụdị ahụ ketone emepụtara na nri ketogenic, nwere ike imezi BDNF.

BHB nwekwara ike imeziwanye okwu nke ụbụrụ na-enweta neurotrophic factor (BDNF) ma nwee ike si otú ahụ kwalite mitochondrial biogenesis, plasticity synapti na nkwụsị nrụgide cellular. 

Mattson, MP, Moehl, K., Ghena, N., Schmaedick, M., & Cheng, A. (2018). Mgbanwe metabolic na-adịte aka, neuroplasticity na ahụike ụbụrụ. Nyocha nyocha Nature. Neuroscience, 19(2), 63-80. https://doi.org/10.1038/nrn.2017.156

Mgbe a na-eji mkpụrụ ndụ sel akwara na-amụ ọrịa Alzheimer, BDNF na-achọpụta dị ka isi usoro na-ebute ọganihu dị mma. A makwaara HBOT ka ọ na-abawanye ọkwa nke BDNF nke ukwuu ma bụrụ otu n'ime usoro a na-esi enweta ọganihu na TBI.

Ya mere, ọ bụ ezie na enweghị m obi abụọ na ma ọgwụgwọ HBOT na stem cell ga-abụ ọgwụgwọ dị irè maka TBI na / ma ọ bụ PTSD, echere m na ọ dị mkpa ka isiokwu ahụ bụrụ nke zuru oke. Karịsịa ebe ọ bụ na nri ketogenic nwere akwụkwọ nyocha na-akwado ya dị ka ọgwụgwọ maka usoro ndị dị n'okpuru ebe ndị dere ya chọpụtara na ha yiri n'etiti nsogbu abụọ a. Ma ọ bụ olileanya m na ha ga-agụnye nri ketogenic na ọrụ ha n'ọdịnihu ma ọ bụ ọbụna dee ụfọdụ ụdị mgbakwunye nke ga-enyere aka ịgwa ndị dọkịta na ndị nchọpụta banyere nri ketogenic dị ka ọgwụgwọ nwere ike maka TBI na PTSD.

A na-enweta nri ketogenic na ntinye aka maka ọrịa dị iche iche nke akwara ozi, gụnyere TBI na PTSD. Ọ bụrụ na ị na-achọsi ike maka usoro dị n'okpuru maka nsogbu ndị ọzọ, ị nwere ike ịnụ ụtọ ọtụtụ posts dị na ya Blọọgụ Keto ahụike uche.

Nsogbu mgbakasị ahụ nke post-traumatic (PTSD)

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Ntuziaka nri ụbụrụ efu efu

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