Glutathione na nri ketogenic
Kedu ka nhazi nri ketogenic nke glutathione si ekere òkè n'ịgwọ ụbụrụ gị site na ọrịa uche na ọrịa akwara ozi?
Glutathione bụ isi usoro antioxidant nke ụbụrụ. Ike nri ketogenic iji kwalite mmepụta glutathione na-enye aka karịsịa maka ndị nwere ọrịa uche ma ọ bụ nsogbu akwara ozi. Nri ketogenic na-abawanye mmepụta nke glutathione na ụbụrụ. Usoro ndị ọzọ nke glutathione na-agwọ ọrịa uche na nsogbu akwara ozi bụ nrụzi eriri afọ, mbelata mbufụt nke ụbụrụ site na mmeghachi omume sistemu sistemu nke macrophages, mmeziwanye nke mgbochi ụbụrụ ọbara (BBB). Mweghachi nke mmepụta glutathione na-emekwa ka ọrụ imeju dịkwuo mma, nke na-ebelata ibu mwakpo n'ime ahụ nke nwere ike mechaa mebie ọrụ ụbụrụ (dịka ọmụmaatụ, ọla dị arọ, xenoestrogens).
Tebulu ọdịnaya
Okwu Mmalite
Ọ bụrụ na ị gụọla nke ukwuu na blọgụ a, ị mụtala banyere mbufụt na nrụgide oxidative, yana otu ndị ahụ nwere ike isi mepụta mgbaàmà nke ọrịa uche na ọrịa akwara ozi. O nwekwara ike ịbụ na ị gụọla ihe m dere gbasara usoro ihe na-egbochi oxidant dị ịtụnanya ị nwere n'ime ahụ gị nke na-enyere aka ịlụso mbufụt na nrụgide oxidative ọgụ. Nke a endogenous (ahụ gị na-eme ya!) antioxidant bụ glutathione na mmepụta gị nke glutathione na-abawanye mgbe ị na-aga na nri ketogenic.
Nke a na post ga-atụle ihe kpatara mgbagha na glutathione na ị na-eri nri ketogenic dị oke mkpa n'ịgwọ ọrịa uche ma ọ bụ nsogbu akwara ozi. Anyị ga-ekwu kpọmkwem ihe kpatara ikike nri ketogenic nwere imezi glutathione bụ otu n'ime ụzọ bụ isi ọ na-enyere aka ịgwọ mgbaàmà gị.
Ndị ọzọ blọgụ blọgụ (na-abịa n'oge na-adịghị anya!) ga-atụle ihe glutathione bụ, otú e si eme ya n'ime ahụ gị, na ihe ị nwere ike ime iji mee ka mmepụta glutathione endogenous gị nke ga-ebuli mmetụta ọgwụgwọ ugbua nke nri ketogenic gị maka ọrịa uche.
Mana nke mbụ, ka anyị kwuo maka ihe kpatara ịchọrọ glutathione na-edozi ahụ ị na-enweta na nri ketogenic, kpọmkwem iji gwọọ ọrịa uche gị ma belata mgbaàmà gị.
Glutathione na-agwọkwa Leaky Gut gị.
O nwere ike ịbụ na ị malitela nri ketogenic gị site na nsogbu mgbaze nke ịdị njọ dị iche iche. Mgbe ha na-amụ ndị nwere ọrịa bowel mgbakasị ahụ, ha na-ahụ ihe ịrịba ama na glutathione na-ebelata. Nke a nwere ike ịbụ n'ihi na ọ na-agwụ ike mgbe niile na mbọ ọ na-agba megide nrụgide oxidative na eriri afọ.
Were ya na ezughị oke glutathione iji belata mbufụt na ịlụso nrụgide oxidative ọgụ. N'okwu ahụ, ị na-enweta mmebi nke cell, nke na-enye gị mgbaàmà mgbaze ahụ jọgburu onwe ya. Ka ọkwa glutathione na-ebelata, eriri afọ enweghị ike ịrụzi onwe ya, na-aghọ leaky. Otu eriri afọ na-eme ka usoro ahụ ji alụso ọrịa ọgụ rụọ ọrụ n'ahụ gị, na-abawanye ọrụ mgbochi ụbụrụ yana neuroinflammation.
Neuroinflammation bụ isi ihe na-akpata na pathology nke ọrịa uche ọ bụla m deworo banyere ya na blọgụ a ruo ugbu a. Anyị niile maara na ahụ ike nke eriri afọ anyị na-emetụta ahụ ike nke ụbụrụ anyị na ọnọdụ anyị.
Ya mere, ka ị nọ na nri ketogenic gị na glutathione gị na-edozi, ị ga-eme ka nrụgide oxidative na-agbada n'ime eriri afọ gị. Nke ahụ ga-enyere eriri afọ gị aka ịgwọ (n'ikpeazụ) na, n'aka nke ya, belata neuroinflammation gị na nrụgide oxidative na ụbụrụ gị. Ma nke ahụ bụ otu n'ime ụzọ nri ketogenic ga-esi nyere gị aka ịgwọ ọrịa uche gị.
Glutathione na usoro ahụ ji alụso ọrịa ọgụ
Ndị mmadụ na-eri nri ketogenic na-ekwu na ha anaghị arịakarị ọrịa ma na-arịakarị ọrịa. Ị nwere ike ịnọ na-eche ihe nke ahụ bụ. Enwere ọtụtụ ụzọ dị mkpa nke nri ketogenic na-eme ka ọrụ sistemu ahụ ji alụso ọrịa ọgụ dịkwuo mma. Mana kpọmkwem ka nri ketogeniki na-esi abawanye glutathione yana otu mmepụta nke glutathione ka mma si eme ka usoro ahụ ji alụso ọrịa ọgụ dịkwuo elu, anyị kwesịrị ikwu maka macrophages. A chọrọ glutathione zuru oke iji mee ka mkpụrụ ndụ ọbara ọcha (macrophages) bụrụ akụkụ dị mkpa nke usoro ahụ ji alụso ọrịa ọgụ.
Macrophages dị mma na ọnụọgụ zuru oke na-emepụta ihe nchebe ngwa ngwa na nke dị mkpa n'ịwakpo nje bacteria na nje. Ịchọrọ mmeghachi omume mgbochi siri ike, ozugbo na nke na-akụda mmụọ nye ndị mwakpo. Ihe ị na-achọghị bụ ogologo oge, nke a kpụrụ akpụ na nke na-adịghị arụ ọrụ nke na-eme ka cytokines na-egbuke egbuke dị elu ma na-aga n'ihu na-emepụta ụbụrụ ụbụrụ ruo ogologo oge.
Glutathione na mgbochi ụbụrụ ụbụrụ gị
Ihe mgbochi ụbụrụ ụbụrụ ọbara gị nwere ike ịpụta nke ọma ma ọ bụrụ na ị na-arịa ọrịa uche ma ọ bụ nsogbu akwara ozi. Na nke a bụ nnukwu nsogbu. Ịchọrọ ihe mgbochi ụbụrụ ọbara na-emebibeghị ma na-arụ ọrụ nke ọma iji chebe ụbụrụ gị pụọ na nsị. Ma ọ́ bụghị ya, ụmụ irighiri ihe ndị na-ekwesịghị ịbịaru ụbụrụ gị nso na-eme kpọmkwem otú ahụ. Nke a na-ebute nzaghachi mgbochi ọrịa na ụbụrụ gị iji lụso ụmụ irighiri ihe ndị ahụ na-ekwesịghị ịdị. Nzaghachi mgbochi a na ụbụrụ gị na-emepụta cytokines na-akpasu iwe. Cytokines ndị a na-emepụta mmebi cellular ka ha na-agbalị ịlụso ihe iyi egwu ahụ ọgụ. Kedu nke ga-adị mma ma ọ bụrụ na anyị anaghị enwe ọtụtụ mkpụrụ ndụ na-abanye n'ụbụrụ nke na-ekwesịghị ịdị ebe ahụ n'ihi ihe mgbochi ụbụrụ ọbara na-agbapụta. Neuroinflammation nke na-adịghị ala ala nke na-etolite n'ihi ịgbalite sistemu sistemu ụbụrụ ụbụrụ na-adịghị akwụsị akwụsị n'ihi mgbochi ụbụrụ ọbara gị na-agbapụta bụ isi ihe kpatara mgbaàmà gị.
Ọ bụ naanị na nri ketogenic na-eme ka nrụzi na ndozi nke mgbochi ụbụrụ ọbara n'ụzọ dị iche iche. Nke mbụ, ha na-eme ka mmepụta nke oghere dị mma na nke siri ike, nke bụ akụkụ nke BBB na-aghọ ntanye. Nri ketogenic na-abawanye mmepụta ume na astrocytes, nke bụ otu n'ime ahụ neuronal bụ isi maka ahụike nke BBB.
Ya mere, mmetụta bara uru nke nri ketogenic nwere ike ịdabere n'ịba ụba ụbụrụ nke [ahụ ketone] KB iji kwekọọ n'ọchịchọ metabolic na nrụzi nke ọgba aghara [ọbara-ụbụrụ ụbụrụ] BBB.
CellKB na-achịkwa mbugharị cell na ngosipụta nke protein nkwụsịtụ Banjara, M., & Janigro, D. (2016). Mmetụta nke nri ketogenic na mgbochi ụbụrụ ọbara. KNri etogenic na ọgwụgwọ metabolic: Ọrụ gbasaara na ahụike na ọrịa; Susan, AM, Ed, 289-304. DOI: 10.1093/med/9780190497996.001.0001
Nkwalite na glutathione na nri ketogenic na-enyere aka idobe ma mezie ihe mgbochi ụbụrụ-ọbara.
Glutathione na imeju gị
Imeju gị enweghị ike iwepụ ahụ gị site na mwakpo gburugburu ebe obibi na-enweghị oke glutathione zuru oke. Mwakpo gburugburu ebe obibi a na-achịkwaghị achịkwa, n'agbanyeghị ma ha ga-esi na mgbochi ụbụrụ ụbụrụ gị ma ọ bụ na ha enwetaghị, nwere ike ịmepụta neuroinflammation.
Imeju chọrọ glutathione iji nyere aka wepụ gị site na ihe mgbochi ndị a na ahụike uche gị. Onye ọ bụla n'ime ihe ndị a kwesịrị inwe ọkwa dị iche iche iji kọwaa otú ha si etinye aka na mmepe nke ọrịa uche.
- metabolites ọgwụ
- mycotoxins
- ọla dị arọ
- pesticides
- ahihia ahihia
- xenoestrogens
Ịchọrọ nkwalite nke glutathione nke na-eme na nri ketogenic iji nyere ahụ gị aka iwepụ ihe ndị na-emebi ahụike ụbụrụ gị ma mepụta mgbaàmà gị.
Glutathione na ụbụrụ gị
Ka m doo anya nke ọma. Glutathione bụ ISI ANTIOXIDANT nke ụbụrụ gị na-eji na-eme onwe ya ahụ ike ma na-arụ ọrụ. Ọ bụghị vitamin C na ọ bụghị vitamin E, ọ bụ ezie na a na-eji ndị ahụ dị ka ndị na-akwado glutathione. Ọ bụrụ na ịchọrọ ụbụrụ dị mma, ịchọrọ glutathione dị ka ahụ gị chọrọ ịmepụta iji chebe ma mezie neurons site na mmebi.
Were ya na ị nwere ọrịa uche ma ọ bụ nsogbu akwara ozi. N'ọnọdụ ahụ, ọ ga-abụ na ị nwere akụkụ ụbụrụ gị nke nwere obere glutathione. Ụfọdụ akụkụ ụbụrụ chọpụtara na ọ dị obere na glutathione na nsogbu ụfọdụ gụnyere ihe ndị a:
- Cortex cingulate dị n'azụ n'ime nsogbu na-atụ egwu (OCD)
- Ihe na-akpata nigra na ọrịa Parkinson (PD)
- Occipital na prefrontal cortex na ịda mbà n'obi
- Prefrontal cortex na Bipolar Disorder na Schizophrenia
Ịbawanye mmepụta glutathione nwere ike inyere aka ịlụso nrụgide oxidative ọgụ n'akụkụ ụfọdụ nke ụbụrụ metụtara nyocha gị. Nke a nwere ike ibelata mgbaàmà gị.
Ọbụlagodi na ahụbeghị ọkwa glutathione mbelata n'ụdị akụkụ ụbụrụ maka nsogbu gị, enwere nkwenye zuru oke na akwụkwọ ndị na-achọpụta ọrịa psychiatric na akwara ozi abawanyela ọkwa nke nrụgide oxidative na ọkwa glutathione dị ala n'ozuzu ya.
A na-arụ ụka na Glutathione (GSH) bụ antioxidant endogenous kacha mkpa na ụbụrụ. N'ime afọ ndị na-adịbeghị anya, ọkwa GSH na-adịghị mma etinyewo aka na ọrịa uche dị iche iche, gụnyere psychopathologies metụtara nchekasị.
Zalachoras, I., Hollis, F., Ramos-Fernández, E., Trovo, L., Sonnay, S., Geiser, E., Preitner, N., Steiner, P., Sandi, C., & Morató, L. (2020). Ikike ọgwụgwọ nke glutathione-eme ka ọ dị na psychopathologies metụtara nchekasị. Neuroscience na nyocha banyere biobehavioral, 114, 134-155. https://doi.org/10.1016/j.neubiorev.2020.03.015
Ya mere, iji nri ketogenic na-abawanye ọkwa glutathione na ụbụrụ kpọmkwem bụ otu n'ime usoro nke ọ bụ ọgwụgwọ dị mma maka ọrịa uche gị ma ọ bụ nsogbu akwara ozi.
mmechi
Enwere otutu uru maka onye na-alụ ọgụ maka ọrịa uche ma ọ bụ akara akwara na-abawanye mmepụta glutathione. Na ketogenic na-eme nke ahụ!
Ugbu a, ị nwere ike ịnwe ọdịiche dị iche iche nke mkpụrụ ndụ ihe nketa na-egbochi ike gị ịme ma megharịa glutathione. O nwere ike isiri gị ike ime ya, nke ahụ ga-enyere gị aka ịmata. Ọ bụrụ na ịchọrọ ịbanye n'ime ike nke ahụ gị iji mee glutathione, a ga m akwado ịnwale. 23andMe (njikọ njikọ). Cheta, otu akụkụ nke gị 23andMe Enwere ike ịkwụ ụgwọ maka akaụntụ nchekwa ahụike gị (HSA) ma ọ bụ (FSA) ma ọ bụrụ na ị nwere uru ahụ.
Ozugbo inwere nke gi 23andMe data ị nwere ike ịdenye aha na ebe nrụọrụ weebụ a dị ịtụnanya Genetic Life Hacks (njikọ njikọ) nke ga-enyocha ya wee kọọ ka mkpụrụ ndụ ihe nketa gị na-akwado ike gị ịme na ijikwa ọgwụ antioxidant a dị mkpa ụbụrụ na-agwọ gị chọrọ nke ukwuu!
N'agbanyeghị ihe ị chọpụtara, enwela obi nkoropụ. Enwere ihe anyị nwere ike ime iji mee ka mmepụta glutathione gị dịkwuo elu, ọbụna na nri ketogenic, nke na-arụ ọrụ dị ukwuu nke ịmekwu ya na mbụ.
Ịkwesịrị ịgụ akụkọ a gbasara ụkọ thiamine n'ihi na ụkọ thiamine nwere ike igbochi gị ime glutathione. Ma ị nwere ike na-abanye na nri ketogenic thiamine erughi ya!
Jide n'aka na ị ga-enweta ọtụtụ magnesium, ebe ọ na-eme ka thiamine rụọ ọrụ, ya mere ọ nwere ike ime ihe ya iji nyere aka mee glutathione.
Ọ bụrụ na ịchọtara isiokwu a dị n'elu na-enyere aka, ị nwekwara ike ịmasị blog nke ọzọ na-ekwu maka glutathione.
Abụ m onye ndụmọdụ ahụike uche nke na-eme ụkpụrụ isi mgbaka na-arụ ọrụ na nri nri. Azụlitela m mmemme dị n'ịntanetị dị ka onye nkuzi na onye nchịkwa ahụike na-arụ ọrụ iji jeere ọha mmadụ ozi nke ọma, na-agbalị ịmụta ka ọ ga-esi na-adị ha mma. Ị nwere ike mụtakwuo maka mmemme mgbake Brain Fog n'okpuru:
Dị ka ihe ị na-agụ na blọgụ? Chọrọ ịmụta maka webinars na-abịa, nkuzi na ọbụna na-enye nkwado na iso m na-arụkọ ọrụ maka ebumnuche ọdịmma gị? Debanye aha!
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