GABA na nri ketogenic
Oge echere ịgụ oge: 5 nkeji
Anyị kwesịrị ikwu maka ọrụ GABA na ọrịa uche na ọrịa akwara ozi. Ma mgbe ahụ, m ga-akọwara gị ihe kpatara ketones nwere ike isi nyere aka ịhazi neurotransmitter a.
Kedu ihe bụ GABA?
GABA (gamma-aminobutyric acid) bụ isi ihe na-egbochi neurotransmitter na ụbụrụ, ọ na-arụkwa ọrụ dị oke mkpa n'ịchịkwa mkpali nke neuronal na ịnọgide na-enwe nguzozi n'etiti mkpali neuronal na mgbochi.
Akwụsịla arụrụ ọrụ GABAergic n'ọtụtụ nsogbu uche na akwara ozi, gụnyere nsogbu nchekasị, ịda mbà n'obi, Akwụkwụ na-adọ, schizophrenia, na ọrịa autism.
Mgbanwe na nrịbama GABA nwere ike gbanwee nguzozi n'etiti neurotransmission excitatory na inhibitory na ụbụrụ, na-eduga na mgbaàmà dị iche iche dabere na mpaghara ụbụrụ na sekit ndị metụtara.
Kedu ihe nchọpụta na-ahụ nsogbu na GABA?
Ọtụtụ.
Nsogbu nchekasị na ịda mbà n'obi na-ejikarị eme ihe site na ahaghị nhata n'etiti excitatory na inhibitory neurotransmission na mpaghara ụbụrụ dị ka amygdala na prefrontal cortex. Mbelata akara ngosi GABA na mpaghara ndị a nwere ike ibute mmụba neuronal excitability na hyperarousal, nke nwere ike itinye aka na nchekasị na ọnọdụ ọnọdụ.
Akwụkwụ na-adọ bụ ọrịa akwara ozi na-eji njide ọdịdọ na-eme ugboro ugboro, ọ na-ejikọkarịkwa ya na ọgbaghara na nrịbama GABA. Mbelata akara ngosi GABA nwere ike iduga hyperexcitability na ọrụ ọdịdọ, ebe mmụba GABA nwere ike ibute nsị na mmetụta anticonvulsant.
Schizophrenia bụ ọrịa mgbakasị ahụ gbagwojuru anya nke jikọtara ya na ihe na-adịghị mma na ọtụtụ sistemụ neurotransmitter, gụnyere GABA. Mbelata GABA nrịbama na prefrontal cortex na mpaghara ụbụrụ ndị ọzọ etinyewo aka na mbelata ọgụgụ isi na akara ngosi dị mma (dị ka ọhụụ na aghụghọ) nke schizophrenia.
Nsogbu dị iche iche nke Autism bụ nsogbu nke mmepe neurodevelopment nke ejiri nkwurịta okwu ọha na eze na-adịghị mma na omume ugboro ugboro mara. GABAergic dysfunction etinyela aka na pathophysiology nke Autism, na mgbanwe na GABA nrịbama ka a hụrụ n'ọtụtụ mpaghara ụbụrụ na ndị nwere autism.
Ketones na GABA
Kedu ihe jikọrọ ihe a niile na nri ketogenic? Aga m agwa gị. N'ihi na a chọrọ m ka ị ghọta ụzọ niile ị ga-esi nwee mmetụta nke ọma. ⬇️
E gosipụtara D-β-hydroxybutyrate (BHB; ahụ ketone) iji welie akara ngosi GABA na ụbụrụ, nke nwere ike inwe mmetụta bara uru na ọrụ ọgụgụ isi na ọrịa akwara ozi.
E gosikwara acetoacetate (ahụ ketone ọzọ) iji gbanwee akara GABA na ụbụrụ. Anyị ka na-achọpụta otú, ma mmetụta bụ nnọọ n'ebe ahụ.
Otu usoro a tụrụ aro maka mmetụta acetoacetate na akara GABA bụ na ọ nwere ike ịbawanye nnweta GABA site n'ịkwalite ọrụ nke GABA-synthesizing enzyme glutamic acid decarboxylase (GAD).
GAD (enzyme) chọrọ cofactor pyridoxal 5'-phosphate (PLP) maka ọrụ ya, na acetoacetate (anụ ahụ ketone) egosila na ọ na-abawanye ohere PLP na ụbụrụ. Nke a nwere ike ibute mmụba na ntọhapụ GABA, na-eduga na mgbama GABA emelitere. Maka ndị na-amaghị, PLP bụ ụdị B6 na-arụ ọrụ. Vitamin B6 na-etinye aka na metabolism nke amino acids, njikọ nke neurotransmitters dị ka serotonin na dopamine, na nhazi nke okwu mkpụrụ ndụ ihe nketa.
Mara: Nke a bụ ihe mere m ji nwee mmasị ijikọta nri ketogenic na oriri na-edozi ahụ na-abawanye n'oge ọgwụgwọ. Enwere mmetụta synergistic!
Usoro ọzọ a na-atụ aro bụ na acetoacetate nwere ike gbanwee ndị na-anabata GABA, nke bụ protein ndị na-edozi mmetụta nke GABA na excitability neuronal.
E gosipụtara acetoacetate iji kwalite ọrụ nke ndị na-anabata GABA-A na ụbụrụ. GABA bụ neurotransmitter na ụbụrụ na-enyere aka ịchịkwa ọrụ ụbụrụ. Enwere ụdị nnabata abụọ nke GABA nwere ike ijikọ, nke a na-akpọ GABA-A na GABA-B. Ndị na-anabata GABA-A na-eme ngwa ngwa iji kwụsị neurons ka ọ na-agbapụ, ebe ndị na-anabata GABA-B na-arụ ọrụ nwayọọ nwayọọ iji belata ọrụ na ụbụrụ. Ụdị abụọ nke ndị na-anabata ya dị mkpa maka ịnọgide na-enwe nguzozi n'etiti ọrụ ụbụrụ na ntụrụndụ.
mmechi
Ya mere, ị nwere ya. Ugbu a, ị ghọtara karịa ka nri ketogenic na-enyere aka ịhazi GABA neurotransmitter na ihe ọ pụtara maka ọgwụgwọ ọtụtụ nsogbu akwara ozi na ọrịa uche.
Gaa na-eme mkpebi mara mma nke ọma na mgbake gị site na ọrịa uche na nsogbu akwara ozi!
Ọ bụrụ na ịmee ọchụchọ na blọọgụ a (n'okpuru ibe) na nyocha gị, ị ga-ahụ akụkọ na-ekwu maka GABA na-enye nsogbu ka ọ na-emetụta nyocha gị. Nke a bụ ụfọdụ n'ime ndị ị nwere ike ịmasị gị!
Ma ọ bụrụ na ịchọrọ enyemaka ịmụta ka esi etinye nri ketogeniki na ịhazi mgbakwunye gị na mgbanwe ndụ gị maka ụbụrụ ka mma, a na-anabata gị ka ịlele mmemme mgbake Brain Fog m.
References
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