Nri Ketogenic na Vitamin D Metabolism: Gịnị Ka Anyị Maara
Oge echere ịgụ oge: 6 nkeji
Nyochaa wee pụta na-eme ike ya niile iji nyochaa mmetụta nke Ketogenic Diets na vitamin D. Ịbụ nnukwu onye ofufe nke abụọ; Echere m na ọ ga-eme ka blọọgụ na-adọrọ mmasị ma na-enye aka na ebumnuche m nke ịmara ụzọ niile ị ga-esi nwee mmetụta ka mma.
Okwu Mmalite
Na nyocha sayensị a, nke e bipụtara na Dec 2022, ụfọdụ ndị ọkachamara gwuru miri emi n'ime nchọpụta ntinye aka na ihe ndị ọzọ nwere ike imetụta njikọ dị n'etiti nri Ketogenic na vitamin D. Ha lebakwara anya na mmekọrịta nke mkpụrụ ndụ ihe nketa! Ya mere, m ga-ewepụ ihe ha hụrụ ka ị nwee ike ịghọta nke ọma ka nri ketogenic nwere ike isi metụta ọkwa vitamin D gị.
Ndị nchọpụta ahụ chọpụtara nyocha ise emere na ndị toro eto nwere ahụike, otu n'ime ndị nwere ụdị ọrịa shuga 2, yana asaa n'ime ndị nwere ọrịa akwụkwụ na-enyocha ọkwa vitamin D tupu yana ntinye aka. Gịnị ka ha chọtara? Nke a bụ nchịkọta maka ịdị mma gị! ⬇️
Ketones
Nke mbụ, anyị kwesịrị iwebata ụfọdụ n'ime okwu ndị e ji mee ihe n'akụkụ a nke nlebanya ndị odee. Ka m gosi gị 25(OH)D na 1,25(OH)2D. Ọ ga-eme ka ịgụ akụkụ a dịkwuo mfe nghọta.
25(OH)D bụ abbreviation maka 25-hydroxyvitamin D. Ọ bụ ule ọbara eji atụ ọkwa vitamin D n'ime ahụ gị. Mgbe ahụ vitamin D na-amịkọrọ ya, a na-agbanwe ya ka ọ bụrụ 25-hydroxyvitamin D (25(OH)D), nke bụ isi vitamin D na-ekesa n'ọbara. A na-ewere ịtụ ọkwa 25(OH)D dị n'ọbara ka ụzọ kacha mma iji chọpụta ọkwa vitamin D mmadụ.
1,25 (OH) 2D bụ abbreviation maka 1,25-dihydroxyvitamin D. Ọ bụ ụdị vitamin D na-arụ ọrụ nke a na-emepụta n'ime ahụ site na usoro mmeghachi omume metabolic nke na-agụnye imeju na akụrụ. 1,25 (OH) 2D bụ hormone nke na-enyere aka ịhazi ọkwa nke calcium na phosphorus n'ime ahụ, nke dị mkpa maka ịnọgide na-enwe ọkpụkpụ dị mma.
N'adịghị ka 25 (OH) D, nke a na-ewere dị ka akara kachasị mma maka ọnọdụ vitamin D zuru oke, a na-atụkarị ọkwa 1,25 (OH) 2D iji nyochaa ụfọdụ ọnọdụ ahụike na-emetụta calcium na ọkpụkpụ ọkpụkpụ, dị ka ọdịda akụrụ, hyperparathyroidism, na ụfọdụ ọrịa mkpụrụ ndụ ihe nketa na-adịghị ahụkebe.
Ihe ha chọpụtara bụ na na mbụ, a na-ahụkarị vitamin D dị ala na ndị ọrịa Ketogenic Diet, mana mgbakwunye nwere ike ịbawanye ọkwa vitamin D. Mmepụta ahụ ketone site na nri Ketogenic na-emepụta gburugburu acid nke nwere ike ime ka imeju na akụrụ hydroxylase rụọ ọrụ, na-egbochi ntughari nke vitamin D na ụdị ọrụ ya. A hydroxylase bụ enzyme nke na-agbakwunye otu hydroxyl (-OH) na mkpụrụ ndụ ihe nketa, nke bụ nzọụkwụ dị mkpa n'ọtụtụ usoro ndu, dị ka ntụgharị vitamin D.
Ndị na-ede akwụkwọ na-atụle acidosis nke sitere na mmepụta nke ketone ozu nke nwere ike ibelata vitamin D na-ejikọta protein, na-ebelata ọnụ ọgụgụ nke vitamin D na-ekesa na-arụ ọrụ. Otu n'ime nchọpụta nyocha nke e zoro aka na ya gosiri na ịgbaso otu KD, 25 (OH) D mụbara, mgbe 1,25 (OH) 2D belatara, na-atụ aro mmetụta nke KD na hydroxylase. Mana achọpụtara na 1,25 (OH) 2D nwere obere ndụ ọkara ma ọ nwere ike ọ gaghị abụ akara ngosi a pụrụ ịdabere na ya nke ọkwa vitamin D.
Ma biko mara na nri ketogenic eme nke ọma anaghị emepụta ọnọdụ acidosis na-adịghị ala ala.
macronutrients
Ndị mmadụ n'otu n'otu na nri ketogenic na-erikarị nri ndị nwere oke abụba, nke nwere ike iduga na-eri nri vitamin D na-eri nri na ọkwa dị elu nke vitamin D na-ekesa. Otu nnyocha nyocha ha nyochara chọpụtara na isiokwu ndị na-agbaso nri obere carbohydrate / abụba dị elu. nwere ọkwa dị elu nke 25 (OH)D ma e jiri ya tụnyere ndị na-eri nri ọwụwa anyanwụ Europe.
Fatty acids na nri nwekwara ike imekọrịta ihe na cholecalciferol na mmịnye eriri afọ, yana mgbakwunye vitamin D na-adị irè karị ma a na-enye ya nri nwere nnukwu abụba. Bile acid, mụbara mgbe ọ risịrị abụba, ka akọọrọ na ọ na-eme ka ndị na-anabata vitamin D rụọ ọrụ.
Nri oriri nke macronutrients ndị ọzọ, dị ka protein, nwekwara ike imetụta isi enzymes nke vitamin D. Otú ọ dị, ọ dịghị data dị ugbu a maka mmetụta nke Ketogenic Diets na ndị a isi enzymes metabolic.
ibu Loss
N'ime ọmụmụ ihe niile nyochara nsonaazụ Ketogenic Diets (KDs) na vitamin D na isiokwu ahụike, oke ibu dị, nke nwere ike kpuchie mmetụta net nke Ketogenic Diets.
Ha hụrụ naanị otu ọmụmụ nke tụnyere mmetụta nke KD na nri ọnwụ ọzọ (nri Mediterranean) na-ekesa 25 (OH) D. Na n'ime ọmụmụ ihe ahụ, mgbe oke ibu site na nri Ketogenic nke obere carbohydrate dị ala (VLCKD), ọnụọgụ ọbara 25 (OH) D mụbara nke ukwuu, ebe mgbe nri Mediterranean gasịrị, mmụba na vitamin D abụghị ihe ndekọ ọnụ ọgụgụ.
homonụ
Nke a na akụkụ bụ na-akpali na kwesịrị ụfọdụ onodu n'ihi na m na-echeghị na ọ na-akawanye atụle zuru ezu. Ya mere, m ga-eme ụfọdụ nkọwa na nzọụkwụ-site-nzọụkwụ ụzọ. Ị gaghị achọ ka uche gị ghọta akụkụ a mara mma!
A maara nri ketogenic (KD) iji meziwanye mmetụta insulin.
Insulin bụ homonụ nke na-achịkwa ọkwa shuga dị n'ọbara ma akọpụtala na ọ nwere mmetụta na ahụike ọkpụkpụ yana vitamin D metabolism.
E gosiputara insulin na-agbadata ihe na-eto eto fibroblast 23 (FGF23), nke mkpụrụ ndụ ọkpụkpụ na-emepụta ma na-arụ ọrụ dị mkpa na renal phosphate na vitamin D metabolism.
FGF23 bụ homonụ nke na-egbochi α-hydroxylase n'ụzọ anụ ahụ, enzyme nke na-ahụ maka ịtụgharị vitamin D n'ụdị ọrụ ya. Ọ na-ebelata nhazi vitamin D na-arụ ọrụ.
Ya mere, ọkwa dị elu nke FGF23 nwere ike iduga ọkwa vitamin D dị ala.
Nyere na insulin nwere ike wedata FGF23, ịba ụba insulin site na nri Ketogenic nwere ike ibute mbelata ọkwa FGF23 yana mmụba nwere ike na hydroxylated (ụdị arụ ọrụ) vitamin D.
Nke a ga-egosi na nri Ketogenic nwere ike ịnwe mmetụta dị mma na vitamin D metabolism.
Ọrịa microbiome
Atụpụtala nri ketogenic iji gbanwee microbiota gut site na ibelata ụbara nke Firmicutes na ịbawanye ụba nke Bacteroidites na ụdị microbial dị iche iche.
Nke a nwere ike inwe mmetụta maka vitamin D metabolism, ebe enwere ihe akaebe na probiotics nwere ike ịbawanye ọkwa vitamin D na-ekesa ma na-emetụta ọkwa protein nke ndị na-ebugharị vitamin D, si otú ahụ na-akwalite nnabata ya.
Ndị ode akwụkwọ kwuru na enweghị ezigbo ihe akaebe gbasara etu gut microbiome si agbanwe na nri ketogenic nwere ike imetụta ọkwa vitamin D.
Onye ga-esi na ya! Achọrọ m ịma! Ma ka ọ dị ugbu a, anyị ga-aga n’ihu na-amụta ụzọ niile anyị ga-esi na-enwekwu obi ụtọ. Ka anyị gaa n'ihu na-amụta ihe anyị nwere ike ime site na nyocha a magburu onwe ya!
Genes
Tinyere ihe ndị metụtara gburugburu ebe obibi, mgbanwe mkpụrụ ndụ ihe nketa na mkpụrụ ndụ ihe nketa na-etinye aka na njikọ cholesterol, hydroxylation, na njem vitamin D nwere ike imetụta ọkwa vitamin D.
Mkpụrụ ndụ ihe nketa SNP (otu nucleotide polymorphism) bụ ụdị mgbanwe mkpụrụ ndụ ihe nketa na-agụnye otu mgbanwe nucleotide na usoro DNA nke mkpụrụ ndụ ihe nketa. Ọ nwere ike imetụta otu anyị si echekwa, bufee, ma ọ bụ gbanwee micronutrients ka ọ bụrụ ụdị dị ndụ.
Nyocha ha banyere nyocha ahụ chọpụtara mkpụrụ ndụ ihe nketa 35 na ọtụtụ SNP metụtara ọkwa vitamin D, na-atụ aro na mgbanwe mkpụrụ ndụ ihe nketa nwere ike gbanwee nzaghachi onye ọ bụla na nri ketogenic.
Ọ bụ akụkụ nke ihe mere na m Brain Fog Iweghachite Mmemme, m na-akụziri ndị mmadụ otú e si eme a nutrigenomics analysis ka ha nwee ike hazie ha supplementation nke Vitamin D na ndị ọzọ dị mkpa nri ndị dị mkpa maka ezigbo ụbụrụ ahụ ike.
mmechi
Yabụ na nke ahụ bụ ọtụtụ ozi. Ọ ga-amasị gị ịma akara ala?
Lee ya ebe a. N'ọtụtụ ọmụmụ ihe, a kọrọ na mmụba nke vitamin D na-ekesa.
Lelee ya onwe gị na ntụaka ma ọ bụrụ na ị nwere mmasị!
References
Detopoulou, P., Papadopoulou, SK, Voulgaridou, G., Dedes, V., Tsoumana, D., Gioxari, A., … & Panoutsopoulos, GI (2022). Nri Ketogenic na Vitamin D Metabolism: Nyochaa Ihe akaebe. Metabolites, 12(12), 1288. https://doi.org/10.3390/metabo12121288