Nri Ketogenic maka Ọrịa Ọcha
Oge echere ịgụ oge: 8 nkeji
Ụbụrụ na-abụkarị ihe isi awọ na ihe ọcha. Ihe isi awọ na-ekpuchi n'èzí ụbụrụ anyị, nke a na-akpọ cortex, nke pụtara ogbugbo. Ihe ọcha na-abụkarị n'ime. Ihe na-acha ọcha nwere eriri irighiri akwara nke jikọtara akụkụ dị iche iche nke ụbụrụ, ma kpuchie ya n'ọbọ myelin. Ọbọ nchekwa a na-acha ọcha n'ihi na ọ bụ naanị abụba mejupụtara ya, yana ụdị ụmụ irighiri ihe ndị ọzọ. Ọrụ ọcha bụ iduzi ozi wee bugharịa ya site n'otu akụkụ nke ụbụrụ gaa na nke ọzọ.
Ọrịa ụbụrụ ischemic na-adịghị ala ala, ọrịa obere arịa CNS, leukoaraiosis, hyperintensities na-acha ọcha, ọnya ọcha, infarcts lacunar, ọrịa microvascular, ma ọ bụ obere ọrịa arịa bụ aha niile na-ezo aka n'otu ihe ahụ. Ha niile bụ Ọrịa White Matter.
Kedu ihe na-ebute ọrịa White Matter?
Ọrịa na-acha ọcha pụtara na arịa ọbara na-enye ihe na-acha ọcha emechiela, gbajie, ma ọ bụ zaa aza n'okpuru nrụgide, na-eduga n'inweta ikuku oxygen na micronutrients na-ezuru sel akwara. Obere arịa ọbara na-anwụ, nke na-ebelata ma ọ bụ kpochapụ kpamkpam isi iyi ike maka mkpụrụ ndụ ụbụrụ nke otu arịa ọbara ahụ na-enye. Ọrịa ọcha bụ okwu na-ezo aka na mmebi na-adịgide adịgide n'otu akụkụ nke ụbụrụ nke mbelata ọbara eruba kpatara.
N'ụbụrụ, ihe ndị a na-emekarị na oghere periventricular, nke bụ etiti ụbụrụ. Ihe kpatara nke a bụ na arịa ọbara dị n'akụkụ a nke ụbụrụ nwere obere dayameta, dị ntakịrị dị ka eriri ntutu. N'ihi ya, ọbụna obere mmebi na mpaghara a nwere ike ịkpata nsogbu. Mbufụt na-akpata mmebi a.
Kedu ihe na-akpata neuroinflammation?
Achọpụtala akụkụ ọrụ microglia arụpụtara ọhụrụ ka ọ na-enye aka na nzaghachi okwu ọcha na mmalite ọrịa CNS na ọganihu. Microglia na-egosi usoro mkpụrụ ndụ dị iche iche na ọdịdị ọdịdị dabere na ụdị ọrịa na mpaghara ụbụrụ, karịsịa na ihe ọcha. N'ọgwụgwụ nke ọrịa ahụ, microglia na-arụ ọrụ nke ọma nwere ike ime ka ọrịa na-aga n'ihu na ọrịa ndị na-acha ọcha site na pro-inflammatory, oxidative, na excitotoxic mmetụta, na-emebi myelin nrụzi na ịkpata neurodegeneration.
Ka m nye ihe atụ nke ihe nke a dị ka. Ụfọdụ microglia na-etinye n'ike n'ike n'ime ebe na-akpasu iwe nke ukwuu wee malite ịkụda ihe ndị ha na-ekwesịghị. Ha na-amalite ịwa ahụ (phagocytosis) mkpụrụ ndụ na akụkụ ndị na-anwụbeghị. Ụfọdụ n'ime ha bụ myelin na ihe ọcha. Ma ọ bụrụ na anyị ajụọla usoro ahụ ji alụso ọrịa ọgụ, a gaara echekwala ọtụtụ myelin.
Ị maara ihe na-eme microglia obi ụtọ, jụụ, na ịrụ ọrụ? Nri ketogenic. Ọ dị m ka m na-eme ihe a? Abụghị m. Nọgide na-agụ.
Kedu ka nri ketogenic ga-esi nyere aka belata neuroinflammation na-akpata ọrịa White Matter?
N'ime ọmụmụ ihe a, ndị nchọpụta nyochara mmetụta ọgwụgwọ nke nri ketogenic (KD) na omume ịda mbà n'obi na ụdị òké. Nsonaazụ gosiri na nri ketogenic mere ka omume ịda mbà n'obi dịkwuo mma. Ha kwuru na ọ ga-abụ na a na-edozi ihe mgbaàmà ahụ site na mweghachi nke mkpali mkpali microglial na excitability neuronal.
N'ozuzu, anyị gosipụtara mmetụta ọgwụgwọ nke KD na omume ịda mbà n'obi, nke nwere ike ịbụ onye ogbugbo site na mweghachi nke microglial mkpali activation na neuronal excitability.
Guan, YF, Huang, GB, Xu, MD, Gao, F., Lin, S., Huang, J., … & Sun, XD (2020). A na-edozi mmetụta mgbochi ịda mbà n'obi nke nri ketogenic site na mweghachi nke microglial activation na neuronal excitability na mpụta habenula. Ụbụrụ, Àgwà, na Ọdachi, 88, 748-762. https://doi.org/10.1016/j.bbi.2020.05.032
N'ime ọmụmụ ihe a na-esote, ndị nchọpụta lere anya nchebe na mgbochi mkpali nke nri ketogenic na ụdị òké nke ọrịa Parkinson. Ha na-eji neurotoxin nke na-ebibie neurons dopaminergic na substantia nigra, mpaghara ụbụrụ na-etinye aka na njikwa mmegharị. Nbibi nke neurons ndị a na-eduga n'ịrụ ọrụ moto na mgbaàmà ndị ọzọ yiri ọrịa Parkinson na ụmụ mmadụ. Nsonaazụ gosiri na mgbe e nyere ụmụ oke ahụ nri ketogenic tupu ekpughere ya na neurotoxin, nsogbu ụgbọ ala ha ka mma. Nri ahụ nyekwara aka chebe mkpụrụ ndụ ụbụrụ nke na-ahụ maka imepụta dopamine, nke na-emebikarị na ọrịa Parkinson. Nri ketogenic belatara ịgbalite ụfọdụ mkpụrụ ndụ na-alụso ọrịa ọgụ (microglia) n'ụbụrụ wee belata ọkwa nke ụmụ irighiri ihe na-akpata mbufụt (cytokines proinflammatory) na mpaghara emetụtara.
Ihe omuma a gosiputara na iji KD megharia ya mere ka nsogbu moto nke MPTP (neurotoxin kpatara) belata.
Yang, X., & Cheng, B. (2010). Ihe omume neuroprotective na mgbochi mkpali nke nri ketogenic na-akpata neurotoxicity nke MPTP. Akwụkwọ akụkọ nke neuroscience molecular, 42, 145-153. https://doi.org/10.1007/s12031-010-9336-y
Nlebanya a na-esote sara mbara na-abanye n'ime usoro mkpụrụ ndụ ihe nke na-achịkwa ka microglia, mkpụrụ ndụ mgbochi ụbụrụ si akpa àgwà n'ụzọ dị iche iche. Microglia nwere ike ịnakwere steeti na-emerụ ahụ, mbufụt na-akpata ma ọ bụ na-enyere aka, ọnọdụ ọgụ na-alụ ọgụ nke na-echebe ụbụrụ. Nyochaa na-enyochakwa akụ nke data preclinical, nke na-atụ aro na ịgbaso nri nri ketogenic (KD) nwere ike iduga n'ọtụtụ mgbanwe bara uru na sel microglial.
Mgbanwe ndị a dị ka ọ na-esite na mgbochi nke ụzọ ndị ga-eme ka microglia na-aga n'ihu na-emerụ ahụ, steeti ndị na-akpasu iwe. Site n'ime nke a, nri ketogenic nwere ike ịkwalite ọnọdụ enyemaka, mgbochi mkpali na microglia, nke nwere ike ịbara ndị nwere ọnọdụ akwara ozi dị iche iche uru.
Na mgbakwunye, ọtụtụ data izizi na-egosi na iso KD, usoro a haziri ahazi na-ewere ọnọdụ na sel microglial. Usoro ndị ahụ yiri ka ọ na-ebute mgbochi nke ụzọ na-achịkwa nnweta na mmezi nke steeti / phenotypes nke na-ebutekarị pro-inflammatory microglial…
Morris, G., Puri, BK, Maes, M., Olive, L., Berk, M., & Carvalho, AF (2020). Ọrụ nke microglia na ọrịa neuroprogressive: usoro na mmetụta neurotherapeutic enwere ike nke ketosis kpatara. Ọganihu na Neuro-Psychopharmacology na Biological Psychiatry, 99, 109858. https://doi.org/10.1016/j.pnpbp.2020.109858
Ndo. Ị chọrọ ụfọdụ ihe akaebe sayensị ka ị kwenye? Nsogbu adịghị. Enwetara m gị! Kedu maka edemede a na-esote, Akpọrọ ya aha, Ọrụ ọgwụgwọ nke Ketogenic Diet na Ọrịa Neurological.
Nyocha a na-emesi ike na nri ketogenic nwere ike inye uru ọgwụgwọ maka ndị ọrịa nwere nsogbu akwara ozi, karịsịa site n'ịgbasa neuroinflammation, isi ihe na-enye aka na ọnọdụ ndị a. Site n'inyocha akwụkwọ sayensị, o doro anya na nri ketogenic nwere ike imetụta ọ bụghị naanị usoro ọrịa akwara ozi ndị a kamakwa ịdị irè nke ọgwụgwọ ha. Ndị na-ede akwụkwọ na-atụ aro na nri ketogenic kwesịrị ịbụ akụkụ nke ọgwụgwọ maka ndị nwere nsogbu akwara ozi.
Maka oge a, ọ dị ka KD nwere ike inye uru ọgwụgwọ na ndị ọrịa nwere nsogbu akwara ozi site n'ịchịkwa nguzozi n'etiti usoro pro- na antioxidant na pro-excitatory and inhibitory neurotransmitters, na modulating mbufụt ma ọ bụ na-agbanwe ihe mejupụtara nke gut microbiome.
Pietrzak, D., Kasperek, K., Rękawek, P., & Piątkowska-Chmiel, I. (2022). Ọrụ ọgwụgwọ nke nri ketogenic na nsogbu akwara ozi. Nri, 14(9), 1952. https://doi.org/10.3390/nu14091952
mmechi
Ya mere, gịnị kpatara onye ndụmọdụ ahụike uche ji nwee mmasị na ahụike ụbụrụ na-ede banyere ọrịa White Matter na ijide n'aka na ị maara nri ketogenic bụ ọgwụgwọ nwere ike ime? N'ihi na ụfọdụ n'ime gị (ma ọ bụ ndị ị hụrụ n'anya) ga-enwe mmetụta, ncheta na nguzozi akara nke na-abịa na ọrịa dị iche iche nke White Matter. Ma mgbe achọpụtara ha na nyocha, a ga-enye ha nhọrọ ọgwụgwọ na-adịghị arụ ọrụ.
Ọgwụgwọ ndị dị ugbu a, dị ka ị nwere ike iche n'echiche, bụ enweghị mmụọ mmụọ—ọgwụgwọ anụ ahụ, ọgwụ ọbara mgbali elu na ọrịa shuga, na ilele cholesterol gị. Ị nwere ike ịgụ gbasara nhọrọ ọgwụgwọ ọdịnala ndị a ebe a:
https://my.clevelandclinic.org/health/diseases/23018-white-matter-disease
Ma eleghị anya, kama ịgwa ndị mmadụ ka ha ghara ichegbu onwe ha banyere mmebi ihe ọcha na-ebuli na nyocha dị ka "ịka nká" ma ghara ichegbu onwe ya banyere ya, anyị nwere ike ịnweta ndị ọkà mmụta akwara ozi na-enye nri ketogenic.
Ma eleghị anya, onye na-ahụ maka akwara ozi nwere ike ịkọwara mmadụ na nri ketogenic, n'otu oge, nwere ike ịkwụsị, jiri nwayọọ nwayọọ, ma ọ bụ ọbụna gbanwee ọrịa ha na-acha ọcha site n'ịgbasa nsogbu metabolic na usoro ahụ ji alụso ọrịa ọgụ ozugbo.
Kedu ihe kpatara na-ejighị nri ketogenic gbalite na ọrụ microglial dịka atụmatụ ọgwụgwọ nwere ike ịgwọ ọrịa ndị ọcha?
Dị ka ị pụrụ ịhụ, ihe àmà sayensị adịlarị.
Ọ bụrụ na ịchọrọ enyemaka ịmụta ka esi etinye nri ketogenic maka ọrịa ọcha ma ọ bụ nsogbu akwara ozi ndị ọzọ, ị nwere ike jụọ maka mmemme ịntanetị m n'okpuru:
References
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Ana m elekọta ụbụrụ gị na DR. SULLIVAN (Onye nduzi). (2022, Disemba 14). Ọrịa White Matter. https://www.youtube.com/watch?v=O1ahjr-8qjI
Morris, G., Puri, BK, Maes, M., Olive, L., Berk, M., & Carvalho, AF (2020). Ọrụ nke microglia na ọrịa neuroprogressive: usoro na mmetụta neurotherapeutic enwere ike nke ketosis kpatara. Ọganihu na Neuro-Psychopharmacology na Biological Psychiatry, 99, 109858. https://doi.org/10.1016/j.pnpbp.2020.109858
Pietrzak, D., Kasperek, K., Rękawek, P., & Piątkowska-Chmiel, I. (2022). Ọrụ ọgwụgwọ Ketogenic nri na nsogbu akwara ozi. Nri, 14(9), Nkeji edemede 9. https://doi.org/10.3390/nu14091952
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Yang, X., & Cheng, B. (2010). Ọrụ Neuroprotective na mgbochi mkpali nke nri Ketogenic na Neurotoxicity nke MPTP kpatara. Akwụkwọ Neuroscience Molecular, 42(2), 145-153. https://doi.org/10.1007/s12031-010-9336-y