β-Hydroxybutyrate - BHB salts niile kere hà?
Oge echere ịgụ oge: 6 nkeji
Enwere ozu ketone atọ emebere na nri ketogenic. Ahụ ketone ndị a bụ acetoacetate (AcAc), beta-hydroxybutyrate (BHB), na acetone. Acetoacetate bụ ahụ ketone mbụ emepụtara site na nbibi nke abụba dị na imeju. A na-atụgharị akụkụ nke acetoacetate ka ọ bụrụ beta-hydroxybutyrate, ahụ ketone kachasị ma kwụsie ike na mgbasa.
Ọ bụ ezie na a na-emepụta ahụ ketone atọ na nri ketogenic, blọgụ a bụ maka BHB. Enwere mmasị dị ukwuu n'ịmepụta BHB nke onwe ya site na nri ketogenic na mgbakwunye. Ọtụtụ ndị mmadụ na-eji ụdị ketone dị iche iche na-apụ apụ iji nyere ụbụrụ ha aka ahụike.
Ọrụ nrịbama ndị a nke BHB na-ejikọta gburugburu ebe dị n'èzí na nhazi usoro mkpụrụ ndụ epigenetic na ọrụ cellular, na omume ha nwere ike ịba uru na ọrịa dị iche iche nke mmadụ yana ịka nká mmadụ.
Newman, JC, & Verdin, E. (2017). β-Hydroxybutyrate: metabolite na-egosi. Nyocha kwa afọ nke nri, 37, 51-76. https://www.annualreviews.org/doi/10.1146/annurev-nutr-071816-064916
Mana achọrọ m ka ị ghọta na enwere ụfọdụ ndịiche na ụdị BHB dị.
D-BHB (D-beta-hydroxybutyrate) na L-BHB (L-beta-hydroxybutyrate) bụ ụdị abụọ nke ketone ahu beta-hydroxybutyrate, na ha bụ n'ezie stereoisomers. N'okwu dị mfe karị, ha bụ ụmụ irighiri ihe na-ekerịta otu usoro na usoro kemịkal mana ha nwere nhazi dị iche iche nke atọm na mbara igwe, na-eme ka ha na-ese onyinyo ibe ha.
Ezigbo ọdịiche dị n'etiti abụọ ndị a bụ ọrụ ndu ha na ọrụ ha n'ime ahụ. D-BHB bụ ụdị na-arụ ọrụ ndụ, nke pụtara na ọ bụ nke na-ekere òkè dị ukwuu na mmepụta ume na metabolism.
Mgbe ị na-agbaso nri ketogenic ma ọ bụ na-ebu ọnụ, imeju gị na-emepụta D-BHB dị ka isi ketone ahụ. Ọ na-arụ ọrụ dị ka isi iyi ike ọzọ maka ụbụrụ gị, obi, na mọzụlụ gị mgbe glucose dị ụkọ. D-BHB bụ ụdị egosiri na ọ nwere mmetụta dị mma dị iche iche na usoro cellular, dị ka ịkwalite ọrụ mitochondrial, autophagy, na mitochondrial biogenesis.
Ihe ndị a niile dị mkpa maka ahụike ụbụrụ! Ị nwere ike ịmụtakwu banyere usoro mitochondrial ndị a ebe a na blọọgụ a m dere:
N'ụzọ dị iche, L-BHB bụ ụdị beta-hydroxybutyrate na-adịghị arụ ọrụ. A na-emepụta ya na obere nha n'ime ahụ ma nwee oke ọrụ metabolic. Agbanyeghị, ọ dị mma ịmara na nyocha na nso nso a na-amalite ikpughe ọrụ nwere ike maka L-BHB na usoro cellular dị iche iche.
Kedu ka L-BHB si atụgharị ghọọ D-BHB?
N'ime ahụ mmadụ, ntụgharị nke L-BHB na D-BHB na-eme site na usoro a na-akpọ stereoisomerization. N'ime ụwa molekụla, stereoisomerization bụ usoro ebe molekul na-agbanwe nhazi akụkụ atọ nke atọm, na-atụgharị otu stereoisomer n'ime ọzọ na-agbanweghị ihe nhazi molekụla n'ozuzu ya. Mgbanwe a na nhazi oghere nwere ike ime ka ndịiche dị na ihe onwunwe na ọrụ nke isomers pụta. (Ọ bụrụ na ọ na-esiri gị ike ịhụ nkọwa a, nke a blog bụ ihe a ga-agụrịrị, ebe o nwere ụfọdụ eserese mara mma nke ndị nwere ọgụgụ isi mebere).
N'ime ụwa nke BHB, ntụgharị na-akwado site na enzyme a na-akpọ beta-hydroxybutyrate dehydrogenase (BDH1), nke dị na mitochondria nke mkpụrụ ndụ, bụ isi na imeju.
Enzyme BDH1 na-eme ka ngbanwe mgbanwe n'etiti stereoisomers abụọ, L-BHB na D-BHB. Mmeghachi omume ahụ gụnyekwara coenzyme NAD +/NADH. N'ebe BDH1 na NAD + nọ, L-BHB bụ oxidized iji mepụta acetoacetate mgbe ị na-ebelata NAD + na NADH. N'ikpeazụ, acetoacetate nwere ike ibelata azụ na D-BHB, ebe NADH na-agbanyeghachi na NAD + na usoro ahụ.
Okwesiri iburu n'uche na usoro ngbanwe a adighi nma nke oma, n'ihi na L-BHB di n'ime ahu n'onu ogugu di ntakiri ma e jiri ya tụnyere D-BHB, na enzyme BDH1 nwere mmekorita di elu maka D-BHB. N'ihi ya, ihe ka ọtụtụ n'ime ahụ ketone ejiri maka ike bụ D-BHB, nke bụ ụdị na-arụ ọrụ ndụ nke na-ahụ maka ọtụtụ uru ahụike metụtara ketosis.
Ọmụma dị omimi banyere omume endogenous nke BHB, yana akụrụngwa emeziwanye maka ịnye BHB ma ọ bụ megharịa mmetụta ya, na-enye nkwa maka mmelite ogologo oge ahụike mmadụ na ogologo ndụ.
Newman, John C., na Eric Verdin. β-Hydroxybutyrate: ihe na-egosi metabolite. Nyocha kwa afọ nke nri 37 (2017): 51-76. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640868/
Kedu ụdị BHB m na-ewere?
Ọtụtụ nnu ketone n'ahịa bụ ngwakọta nke D-BHB na L-BHB. Nke a bụ n'ihi na usoro mmepụta nke nnu ketone na-ebutekarị ngwakọta agbụrụ, nke nwere nha nha nke stereoisomer abụọ, D-BHB na L-BHB. A na-akpọ ngwaahịa ndị a mgbe ụfọdụ dị ka “nnu BHB nke agbụrụ” ma ọ bụ naanị “nnu BHB.”
D-BHB bụ nnukwu ketogenic ma na-enye obere kalori karịa ngwakọta agbụrụ nke BHB ma ọ bụ triglyceride cha cha.
Cuenoud, B., Hartweg, M., Godin, JP, Croteau, E., Maltais, M., Castellano, CA, … & Cunnane, SC (2020). Metabolism nke exogenous D-beta-hydroxybutyrate, mkpụrụ ike nke obi na akụrụ na-eri nke ọma. N'ihu Nri, 13. https://doi.org/10.3389/fnut.2020.00013
Ọ dị mkpa iburu n'uche na D-BHB bụ ụdị na-arụ ọrụ nke ndụ, nke ejikọtara ya na ọtụtụ uru ahụike ndị a na-enweta na ahụ ketone, dị ka mmụba ume ike, ọrụ ọgụgụ isi, na usoro cellular. L-BHB, ịbụ onye na-arụsi ọrụ ike na usoro ndu, anaghị etinye aka na uru ndị a.
Mgbe ị na-anwale ketone n'ọbara gị Keto-Mojo (njikọ njikọ), ma ọ bụ ngwaọrụ nyocha ketone ọbara ọ bụla, ị kwesịrị ịma na ha na-atụ naanị D-BHB. Yabụ mgbe ị na-eri nnu elektrọt (D/L-BHB), mmụba nke L-BHB plasma na-agaghị achọpụta site na mita ketone ọbara gị.
Ọ bụ ezie na nnu BHB agbụrụ bụ ihe a na-ahụkarị, ụfọdụ ụlọ ọrụ amalitela imepụta na ịzụ ahịa ihe mgbakwunye ketone nwere naanị ụdị D-BHB, nke a na-akpọkarị "D-BHB salts" ma ọ bụ "D-BHB esters." Ngwaahịa ndị a na-achọ ịnye uru nke ahụ ketone nke ọma site na ibuga isomer D-BHB na-arụ ọrụ naanị. Agbanyeghị, ihe mgbakwunye D-BHB na-adịkarị ọnụ karịa ma e jiri ya tụnyere nnu BHB nke agbụrụ n'ihi usoro mmepụta dị mgbagwoju anya nke gụnyere ikewapụ isomer D-BHB.
Kedu ihe kpatara m ga-eji jiri nnu BHB agbụrụ agbụrụ mgbe m nwere ike ịnweta ụdị D-BHB?
A bịa na L-BHB, ọ na-eme naanị obere akụkụ - gburugburu 2-3% - nke mkpokọta BHB anyị n'oge ibu ọnụ. Nke a emeela ka a na-eche na L-BHB nwere ike ọ gaghị enwe nnukwu ọrụ n'ime ahụ. Mana nyocha amalitela igosi na L-BHB na-eme ihe karịrị naanị ịnọrọ n'akụkụ ichere ka ọ bụrụ D-BHB. Achọpụtara na ọ na-etinye aka na metabolism ma nwee ike ịrụ ọrụ karịa ịbụ onye etiti na beta-oxidation nke abụba.
Dịka ọmụmaatụ, nnyocha e mere n'oge na-adịbeghị anya jiri usoro iji nyochaa ma tụọ nkesa nke L-BHB na D-BHB isomers na anụ ahụ dị iche iche nke oke, ma tupu na mgbe nchịkwa nke ihe mgbakwunye ketone agbụrụ nwere ma isomers. Ha chọpụtara na otu nnukwu dose nke mgbakwunye ketone agbụrụ nwere ma L-BHB na D-BHB kpatara mmụba dị ukwuu na L-BHB na anụ ahụ niile, ọkachasị na ụbụrụ.
Omenala cell na-enye ihe ngosi na L-BHB nwere uru na ibelata mbufụt. Ma ọ dị ka inwe ma L-BHB na D-BHB ọnụ na-ekesa n'otu oge nwere ike inye aka kwalite ọrụ mgbochi.
Agaghị m eleda L-BHB kpam kpam dị ka mgbakwunye ketone dị ala.
A ka na-eme nyocha.
Nchọpụta ndị a na-egosi na D- na L-BHB nwere ọnụọgụ dị iche iche nke absorption na nkesa n'ofe anụ ahụ na ihe dị iche iche nke metabolic nke nwere ike inwe mmetụta dị mkpa maka ngwa ọgwụgwọ, na nyocha ọzọ kwesịrị ileba anya otú ketones si emetụta anụ ahụ ọ bụla dị iche iche.
Pereira, D. (2022, Ọgọọst 14). Kedu ihe kpatara anyị ji chọọ ma D-BHB na L-BHB? KetoNutrition. https://ketonutrition.org/why-do-we-need-both-d-bhb-and-l-bhb/
mmechi
Ọ bụrụ na ị nwere ike nweta aka gị na ụfọdụ D-BHB, gaa n'ihu hụ ma ọ bụrụ na ịchọta na ọ na-arụ ọrụ maka gị karịa L-BHB. Mana ọ bụrụ na ịnweghị ike, ma ọ bụ na ị nweghị ike ị nweta ụdị ụdị bio-yiri karịa, adala mbà. Ana m eji L-BHB n'ihe m chere na ọ bụ ngwakọta agbụrụ, achọpụtara m na ọ na-enyere ụbụrụ m aka n'ezie. Ana m akwado ya ndị mụ na ha na-arụkọ ọrụ. Enwere m obi ụtọ iso akwụkwọ nyocha nke na-apụta iji mụtakwuo.
Atụrụ m anya na ịchọtara blọọgụ a na-enyere aka n'ịmụ ụzọ niile ị ga-esi nweta mma!
References
Cuenoud, B., Hartweg, M., Godin, JP, Croteau, E., Maltais, M., Castellano, CA, … & Cunnane, SC (2020). Metabolism nke exogenous D-beta-hydroxybutyrate, mkpụrụ ike nke obi na akụrụ na-eri nke ọma. N'ihu Nri, 13. https://doi.org/10.3389/fnut.2020.00013
Desrochers, SYLVAIN, Dubreuil, PASCAL, Brunet, JULIE, Jette, MANON, David, FRANCE, Landau, BR, & Brunengraber, HENRI (1995). Metabolism nke (R, S) -1, 3-butanediol acetoacetate esters, nwere ike ịbụ parenteral na enteral nri na ezi ezi uche. Akwụkwọ akụkọ American nke Physiology-Endocrinology na Metabolism, 268(4), E660-E667. https://doi.org/10.1152/ajpendo.1995.268.4.E660
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Lincoln, BC, Des Rosiers, C., & Brunengraber, H. (1987). Metabolism nke S-3-hydroxybutyrate na imeju oke na-agbaze. Ihe omuma nke biochemistry na Biophysics, 259(1), 149-156. https://doi.org/10.1016/0003-9861(87)90480-2
Newman, JC, & Verdin, E. (2017). β-Hydroxybutyrate: metabolite na-egosi. Nyocha kwa afọ nke nri, 37, 51-76. https://www.annualreviews.org/doi/10.1146/annurev-nutr-071816-064916
Storoschuk, K., & Ari D'Agostino, C. "Gịnị kpatara anyị ji chọọ ma D-BHB na L-BHB?" Keto Nutrition: Sayensị iji Ngwa. (Ọgọst 14, 2022). https://ketonutrition.org/why-do-we-need-both-d-bhb-and-l-bhb/
Youm, YH, Nguyen, KY, Grant, RW, Goldberg, EL, Bodogai, M., Kim, D., … & Dixit, VD (2015). Metabolite ketone β-hydroxybutyrate na-egbochi NLRP3 ọrịa mkpali na-agbapụta ọkụ. Ọdịdị nke ọdịdị, 21(3), 263-269. https://www.nature.com/articles/nm.3804
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