Nri Ketogenic: Ụzọ na-enweghị atụ maka ịlụso ọrịa Alzheimer ọgụ
Oge echere ịgụ oge: 30 nkeji
Ihe onye edemede dere: Dịka onye ndụmọdụ ahụike uche nwere ikike nwere afọ iri na isii nke ahụmịhe omume onwe, ejirila m afọ isii gara aga na-atụgharị ndị nwere ọrịa uche na ọrịa akwara ozi na nri ketogenic. O were m ogologo oge ide akụkọ a, ma amataghị m ihe kpatara ya. M na-eche, dị ka onye na-ata ahụhụ site na cognitive adịghị ike na nke onwe m akụkọ ihe mere eme ahụ ike, a post nwere mmetụta mmetụta uche na siri ike ịbụ ebumnobi banyere ya. Enweghị m ọrịa Alzheimer (daalụ maka ịdị mma), mana enwere m nkwarụ ọgụgụ isi nke onye nwere ya. Nkeji 1 ọrịa Alzheimer. Ọzọkwa, dị ka onye ndụmọdụ ahụike uche, m na-anọdụ ala na ndị ọrịa na-ekiri ndị ha hụrụ n'anya na-ahapụ ha n'ihi ọrịa a. Nnyocha ahụ dị n'ihu n'ihu n'isiokwu a karịa ka ọ dị na Septemba 2021 mgbe m malitere blọọgụ a. Nke mere na enwere m ntụkwasị obi siri ike na nkwuputa siri ike m kwuworo na okike nke aha "Nri Ketogenic: Ụzọ Na-enweghị Mmasị Maka Ịlụso Ọrịa Alzheimer ọgụ." Ma ugbu a, ihe dị omimi n'ime afọ m na-agwa m na ọ bụ oge. M na-ede akụkọ blọgụ a na-atụ anya na mmadụ (dị ka gị) ga-achọta ya wee mụta ụzọ dị ike iji jiri nwayọ nwayọ ma ọ bụ kwụsị ọrịa nke ọrịa a maka onwe ha ma ọ bụ onye ha hụrụ n'anya.
Okwu Mmalite
Agaghị m abanye n'ihe ọrịa Alzheimer bụ ma ọ bụ ọnụ ọgụgụ ya na-agbasa. Ọ bụrụ na ị na-eleta ọkwa a, o yikarịrị ka ị ga-amụ maka nhọrọ ọgwụgwọ ka mma, na oge bụ isi. Usoro neurodegenerative dị ka dementia bụ ọnọdụ nwere mmetụta oge. Ogologo oge ị na-echere ịgwọ ihe ndị na-akpata ya, ka a na-emekwu mmebi. Ka o sina dị, ọ dị mkpa ibu ụzọ nweta aka na ọgwụgwọ ndị dị adị na adịghị ike ha. Ihe ọmụma a ga-enye gị ohere iji tụnyere ha na uru ndị nwere ike ịnweta nri ketogenic gị ma ọ bụ ndị ị hụrụ n'anya.
Nhọrọ ọgwụgwọ dị ugbu a maka Alzheimer abụghị ihe dị oke njọ. Ọgwụ akwadoro ugbu a - ndị na - egbochi cholinesterase na ndị na - anabata NMDA - bụ ebumnuche ijikwa akara ngosi kama ilebara usoro ọrịa na - akpata anya na - ebute usoro neurodegenerative.
Cholinesterase inhibitors dị ka Donepezil (Aricept), Rivastigmine (Exelon), na Galantamine (Razadyne). Ọgwụ ndị a na-arụ ọrụ site n'ibelata nkwụsị nke acetylcholine, neurotransmitter na-etinye aka na ebe nchekwa na cognition, bụ nke na-agwụkarị na ndị ọrịa Alzheimer. Mmetụta ndị a na-ahụkarị nwere ike ịgụnye ọgbụgbọ, ọgbụgbọ, na afọ ọsịsa.
Ndị na-anabata NMDA dị ka Memantine (Namenda). Ọgwụ a na-arụ ọrụ site n'ịhazi ọrụ glutamate, neurotransmitter ọzọ na-ekere òkè na ebe nchekwa na mmụta. Ịmebiga ihe ókè nke glutamate nwere ike ịkpata mmebi cellular, nke Memantine na-anwa inye aka igbochi. Mmetụta nwere ike ime gụnyere dizziness, isi ọwụwa, na mgbagwoju anya.
Ọ bụ ezie na ọgwụ ndị a nwere ike inye ahụ efe nwa oge maka ụfọdụ mgbaàmà dị ka mgbakasị ebe nchekwa na mgbagwoju anya, ha na-adakarị nke ukwuu n'ịkwụsị ma ọ bụ ọbụna na-ebelata ọganihu ọrịa ahụ. Ọzọkwa, ọgwụ ndị a na-enwe ọtụtụ mmetụta ndị nwere ike ịkpata ya, sitere na ọgbụgbọ na afọ ọsịsa ruo nnukwu nsogbu ọgba aghara obi.
Ma gịnị banyere nkwa nke ọgwụ mgbochi amyloid beta (Aβ)? E kwere nkwa ndị a dị ka ọgwụgwọ, ma ọ bụrụ na anyị akwụsịtụ ntakịrị, ọgwụ ọrụ ebube a ga-edozi ọrịa Alzheimer. Ọ dị mma?
Ndị na-eso ụzọ nwere mmetụta dị nro na-adịghị mma ejiri ọgwụ mgbochi Aβ na-atụ anya na ha ga-enwe nlọghachi azụ n'ụbụrụ nke ụbụrụ Alzheimer nke dementia ∼8 ọnwa gara aga karịa ma ọ bụrụ na agwọghị ha.
Alves, F., Kalinowski, P., & Ayton, S. (2023). Mfu Mpịakọta Ụbụrụ Ọsọ nke Ngwọta Anti-β-Amyloid kpatara: Nleba Nleba anya na Meta-analysis. Nchọpụta ihe, 100(20), e2114-e2124. https://doi.org/10.1212/WNL.0000000000207156
Ọgwụ ndị a na-emebi ahụike ụbụrụ ogologo oge. Yabụ kedu ihe kpatara na ụwa anyị ga-eji nke a maka ọrịa Alzheimer? Gịnịkwa mere ndị dọkịta na-ahụ maka akwara ozi na-adịghị enye ndị ọrịa nkwenye zuru ezu banyere erughị eru na ihe ize ndụ dị n'iji ọgwụ eme ihe iji nwaa ịgwọ mgbaàmà nke ọrịa Alzheimer? N'ịchọ ime ka mgbaàmà ahụ kwụsịlata nwa oge, anyị nwere ike ime ka ọnọdụ ọrịa ahụ dịkwuo njọ n'amaghị ama.
Na ngalaba ndị na-esonụ, anyị ga-enyocha miri emi n'ime usoro ọgwụgwọ ọrịa ndị na-akpata ọrịa Alzheimer wee chọpụta otú nri ketogenic nwere ike isi na-emekọrịta ihe na usoro ndị a - yana ihe kpatara na ị nwere ikike zuru oke ịmara banyere ya dị ka ọgwụgwọ nwere ike inye gị ma ọ bụ onye ị hụrụ n'anya. .
Na-agwa Hypometabolism Brain na Alzheimer's: Ijikwa nri Ketogenic
Central na Alzheimer's pathology bụ ihe a maara dị ka ụbụrụ hypometabolism. Ka m kọwaa nke ọma ihe okwu ahụ pụtara.
Ụbụrụ hypometabolism na-ezo aka na ọnọdụ nke mbelata ọrụ metabolic na ụbụrụ, nke e ji mbelata nnabata na itinye n'ọrụ nke glucose - isi iyi ike maka mkpụrụ ndụ ụbụrụ. Mbelata nke metabolic dị njọ abụghị naanị enweghị ume, ọ bụ ezie na nke ahụ ga-emebi oke. Ọ na-ebute mkpọmkpọ nke mmetụta ọjọọ nke na-emebi ọrụ neuronal ma na-akpaghasị nzikọrịta ozi n'etiti mkpụrụ ndụ ụbụrụ.
Neurons na-adabere na ike nke ukwuu; ọbụlagodi obere ụkọ ume nwere ike imetụta ikike ịrụ ọrụ ha nke ukwuu. Na-enweghị ike iji glucose maka mmanụ ọkụ, ha na-adịchaghị arụ ọrụ na-ebufe akara, na ike ha ịmepụta njikọ ọhụrụ, dị mkpa maka mmụta na ebe nchekwa, na-emebi. Ka oge na-aga, hypometabolism na-adịgide adịgide nwere ike iduga nkwụsị nke neurons na mbelata nke ụbụrụ ụbụrụ (mbelata nke ụbụrụ), nke abụọ na-enye aka n'ịda mbà n'obi na mpụta nke mgbaàmà ndị metụtara ọnọdụ dịka ọrịa Alzheimer. N'ihi ya, ụbụrụ hypometabolism na-anọchi anya isi ihe na-akpata pathogenesis nke ọrịa neurodegenerative dị iche iche.
Ka m doo anya nke ọma ma ọ bụrụ na ahịrịokwu ikpeazụ ahụ adaghị gị n'ụlọ.
Nke a abụghị okwu arụmụka ma ọ bụ esemokwu na obodo ndị sayensị. Ọmụmụ ihe onyonyo ụbụrụ egosila mgbe niile mbelata nnabata glucose n'akụkụ ụfọdụ nke ụbụrụ Alzheimer. Ọtụtụ nchọpụta ndị ọgbọ nyochara ejikọtala ọrụ metabolic a na-ebelata na mbelata ọgụgụ isi na mwepu ebe nchekwa nke na-akọwa Ọrịa Alzheimer.
Ọ bụghị ihe a na-eche n'echiche ma ọ bụ njikọ nkịtị kama akụkụ siri ike nke pathology ọrịa ahụ. N'ihi ya, ụbụrụ hypometabolism abụghị mmetụta dị n'akụkụ ma ọ bụ ihe si na Alzheimer pụta; ọ bụ akụkụ bụ isi nke usoro ọrịa n'onwe ya.
N'ịbụ ndị na-eche ihe akaebe a na-apụghị ịgbagha agbagha ihu, ichebe hypometabolism ụbụrụ na-apụta dị ka ihe dị mkpa, nke a na-arụ ụka na atụmatụ kachasị mkpa n'ịlụso ọrịa Alzheimer ọgụ. N'agbanyeghị nke ahụ, n'agbanyeghị ọrụ ya na-aga n'ihu na ọrịa ahụ, ụbụrụ hypometabolism ka na-adịghị edozi ya site na ọgwụ ndị dị ugbu a ma ọ bụ ọgwụgwọ nlekọta maka ọrịa Alzheimer.
Structure Brain Hypometabolic na AD
Dịka e kwuru na mbụ, na AD, mmebi nke metabolic a na-apụta ìhè na mpaghara ụbụrụ akọwapụtara nke dị oke mkpa maka ebe nchekwa na ọrụ ọgụgụ isi. Mpaghara abụọ a na-emetụtakarị bụ lobe parietal na cortex cingulate dị n'azụ.
The parietal lobe, nke dị nso n'azụ ụbụrụ, na-ahụ maka ọrụ dị iche iche, gụnyere igodo oghere, nlebara anya, na nhazi asụsụ. Mmebi ya nwere ike ibute ihe isi ike n'ịrụ ọrụ ndị a, na-egosipụta dị ka ịla n'iyi ngwa ngwa, na-agbasi mbọ ike ilegide anya, ma ọ bụ nwee nsogbu n'ịgụ ma ọ bụ ịghọta okwu.
Cortex cingulate dị n'azụ, nke dị n'etiti ụbụrụ, na-arụ ọrụ dị mkpa n'iweghachite ebe nchekwa na njikwa ọgụgụ isi. Arụ ọrụ na mpaghara a nwere ike itinye aka na ihe isi ike na icheta ozi na ime mkpebi, nke bụ akara ngosi nke AD.
Ka ikike mpaghara ndị a iji jiri glucose mee ihe nke ọma na-ebelata, otu ahụ ka ikike ha nwere ịrụ ọrụ ndị a dị oke egwu na-ebelata, na-atụnye ụtụ nke ukwuu na mbelata ọgụgụ isi a na-ahụ na AD.
Mana achọghị m inye gị echiche na ọ bụ naanị akụkụ abụọ nke ụbụrụ na-aghọ hypometabolic na ọrịa Alzheimer.
N'ọrịa Alzheimer, ụbụrụ hypometabolism anọghị n'otu mpaghara, kama ọ na-egosipụta n'ụzọ na-aga n'ihu, na-emetụta mpaghara dị iche iche ka oge na-aga. Ọ bụ ezie na ọ bụ eziokwu na parietal lobe na posterior cingulate cortex so na ndị mbụ na nke kachasị emetụta, ka ọrịa ahụ na-aga n'ihu, akụkụ ụbụrụ ndị ọzọ na-enwetakwa mbelata nnabata glucose na itinye n'ọrụ.
N'ụzọ doro anya, ihu ihu ihu, oche nke onye isi anyị na-arụ ọrụ dị ka ime mkpebi, nkwụsị nsogbu, na nchịkwa mmetụta uche, na-emecha ghọọ hypometabolic na njedebe nke ọrịa ahụ. Mbelata nke metabolic a na lobe ihu nwere ike iduga mgbanwe omume, mmejọ ikpe, na ihe isi ike n'ịrụ ọrụ oge niile.
Mana nsogbu nke ụbụrụ hypometabolism akwụsịbeghị ebe ahụ.
Na ụbụrụ AD, glucose hypometabolism
Kalani, K., Chaturvedi, P., Chaturvedi, P., Verma, VK, Lal, N., Awasthi, SK, & Kalani, A. (2023). Usoro Mitochondrial na ọrịa Alzheimer: ọchịchọ maka ọgwụgwọ. Nchọpụta ọgwụ taa, 103547. https://doi.org/10.1016/j.drudis.2023.103547
a na-ekwukarị na ọ bụ mbelata ike metabolism ike… nke na-egosi na arụrụ ọrụ mitochondrial nwere ike itinye aka na mmepe AD.
N'ọrịa Alzheimer, ụbụrụ hypometabolism na-agbasa n'ụzọ aghụghọ gafere ebe ndị mbụ metụtara, jiri nwayọọ nwayọọ na-erikpu cortex cerebral dum, oyi akwa ụbụrụ nke na-arụ ọrụ dị elu. Ihe kacha mkpa bụ lobe nwa oge, ebe obibi nke hippocampus — ebe nchekwa ụbụrụ. Ka ọrụ metabolic na-ebelata na mpaghara ndị a, ihe mgbaàmà ndị metụtara Alzheimer, dị ka enweghị ncheta, na-apụtawanye ìhè. Mkpokọta nke mmebi nke metabolic a na-egosi mkpa dị oke mkpa nke ịlụso okwu a ọgụ n'ihu.
Dị ka akwụkwọ sitere na National Center for Biotechnology Information (NCBI) nchekwa data, ndị nchọpụta achọpụtala mbelata ojiji glucose na mpaghara ụbụrụ ụfọdụ, na-egosi hypometabolism ụbụrụ. Ihe omume a na-eme ma ọ dịkarịa ala afọ 15 (ikekwe 30) tupu oke ngosipụta zuru oke nke mgbaàmà metụtara ọrịa Alzheimer. Ọ bụ ezie na enwere ike iji nyocha ụbụrụ na nyocha nke ọkpụkpụ azụ iji nyochaa ihe ize ndụ nke ọrịa Alzheimer n'ime afọ iri ma ọ bụ karịa tupu ngosipụta nke mgbaàmà ahụ, gụnyere ụbụrụ dị nro, atụla anya na dọkịta gị ga-enye ọkwa ule a n'oge ọ bụla. . Ugbu a, ụlọ ọrụ ahụike anaghị ewere akara mgbaama mbụ gị nke ọma iji nye ha.
Ọ dabara nke ọma, anyị nwere nri ketogenic - n'ụzọ nkịtị ọgwụgwọ ụbụrụ metabolic.
Inweta ọnọdụ ketosis na-atụgharị isi iyi nke ike sitere na glucose gaa na acid fatty, nke na-agbaji n'ime ahụ ketone, dị ka beta-hydroxybutyrate na acetoacetate.
Ikike nke ahụ ketone na-eme ka metabolism ike mitochondrial guzosie ike na-eme ka ọ bụrụ onye nnọchite anya dabara adaba.
Sridharan, B., & Lee, MJ (2022). Nri Ketogenic: Ngwakọta neuroprotective na-ekwe nkwa maka ijikwa ọrịa Alzheimer na usoro ọrịa ya. Ọgwụ molekụla ugbu a, 22(7), 640-656. https://doi.org/10.2174/1566524021666211004104703
Abụọ n'ime ketones ndị a, beta-hydroxybutyrate na acetoacetate, na-arụ ọrụ nke ọma n'ụzọ mkparị na-agafe metabolism nke glucose na-adịghị arụ ọrụ na ụbụrụ. Mkpụrụ ndụ ụbụrụ nwere ike iburu ha ngwa ngwa ma rụọ ọrụ nke ọma maka mmanụ, si otú ahụ na-eme ka ụbụrụ ụbụrụ dịkwuo ike.
Ma β-HB na acetoacetate bypass glycolysis iji belata acetyl-CoA, nke enwere ike ịbanye na okirikiri Krebs, ma nwee ike ịbawanye ike dị na ụbụrụ. Na AD, nnabata ụbụrụ ketone adịghị emebi emebi, nke na-eme ka KB bụrụ isi iyi ike ọzọ enwere ike.
Zhu, H., Bi, D., Zhang, Y., Kong, C., Du, J., Wu, X., … & Qin, H. (2022). Nri ketogenic maka ọrịa mmadụ: usoro dị n'okpuru na ikike maka mmejuputa ụlọ ọgwụ. Ntugharị mgbaàmà na ọgwụgwọ ezubere iche, 7(1), 11. https://doi.org/10.1038/s41392-021-00831-w
Mmetụta a niile ọ bụ usoro iwu? Enweghị nchekasị. M na-agba gị ume ka ị kirie vidiyo a nke ụbụrụ na-eji ume na-enwu n'ụzọ nkịtị mgbe ntinye nke naanị otu n'ime ahụ ketone ndị a na nyocha nyocha.
Mana a gwala gị na ụbụrụ chọrọ glucose! Kedu ihe ga-eme m ma ọ bụ onye m hụrụ n'anya ma ọ bụrụ na anyị ebibie carbohydrates dị ala? Ụbụrụ gị na-eme ka glucose niile dị gị mkpa gluconeogenesis, bụ́ nke na-enye ya n'ụzọ ziri ezi na n'usoro oge. N'ezie, iri ọtụtụ carbohydrates nwere ike inye aka mee ka nsogbu nke ụbụrụ hypometabolism malite na.
Mgbe gị ma ọ bụ onye ị hụrụ n'anya gbochiri oriri carbohydrate gị ruo ogologo oge zuru oke, ahụ ga-eji ma abụba nri ị na-eri na abụba ọ na-ere n'ahụ iji mepụta ketones. Ọ bụrụ na mmadụ adịghị eri nri na-edozi ahụ ma ọ bụ nwee ibu dị ala, ọ pụtara na anyị na-abawanye oriri abụba na-eri nri iji mee ka ike dị elu ma belata ohere nke ịbelata ibu ọ bụla.
β-Hydroxybutyrate (βOHB), ahụ ketone, bụ oxidized dị ka mmanụ ụbụrụ.
Achanta, LB, & Rae, CD (2017). β-Hydroxybutyrate na ụbụrụ: otu molekul, ọtụtụ usoro. Nnyocha neurochemical, 42, 35-49. https://doi.org/10.1007/s11064-016-2099-2
Ebe ọ bụ na anyị na-ekwu maka metabolism nke ụbụrụ na ike ụbụrụ, achọrọ m ka ị mara na nri ketogenic anaghị anapụta ike ụbụrụ site n'inye ihe ọzọ mmanụ ụgbọala. Ha bụkwa ahụ ndị na-egosi ihe gbasara mkpụrụ ndụ ihe nketa.
Ma dị ka nke ahụ metụtara ike, ị kwesịrị ịma na ha na-atụgharị usoro mkpụrụ ndụ ihe nketa na-enye ohere ka e mepụta mitochondria (osisi ike nke mkpụrụ ndụ) ma na-enye ohere ka ụlọ ọrụ ndị dị ugbu a (mitochondria) rụọ ọrụ nke ọma ma rụọ ọrụ nke ọma. Dị ka ị nwere ike iche n'echiche, nke a nwere ọtụtụ uru bara uru na mmetụta ọgwụgwọ maka ụbụrụ Alzheimer na-alụ ọgụ na mmepụta ume.
Mgbe niile, ahụ ketone na-echekwa mitochondria na ọrụ ha na homeostasis ume cell
Dilliraj, LN, Schiuma, G., Lara, D., Strazzabosco, G., Clement, J., Giovannini, P., … & Rizzo, R. (2022). Evolushọn nke ketosis: mmetụta nwere ike na ọnọdụ ụlọ ọgwụ. Nri, 14(17), 3613. https://doi.org/10.3390/nu14173613
Na ịdị mma m, ọ bụghị naanị otu mmetụta a nke nri ketogenic nwere ike idozi hypometabolism ụbụrụ bụ ihe na-atọ ụtọ? Ọ bụ na naanị otu mmetụta a agaghị abụ ọgwụgwọ ka mma naanị ya karịa ọgwụ niile anyị na-eji ugbu a dịka ọkọlọtọ nlekọta? Ee! Ọ ga-abụrịrị. Aga m ahapụ akụkọ a na nke ahụ wee ziga gị n'ụzọ gị maka ọgwụgwọ gị (ma ọ bụ nke ndị ị hụrụ n'anya). Ma enwere mmetụta ndị ọzọ nke nri ketogenic na-enye bụ nke na-enyere aka ịkwụsịlata ma ọ bụ kwụsịlata ọganihu ọrịa Alzheimer. Achọrọ m ka ị mara ha niile.
Nọgide na-agụ ihe.
Nchegbu Oxidative na Ọrịa Alzheimer: Iji Ike Ketogenic
N'ịtụle mmebi nke ọrụ mitochondrial bụ onye na-akwọ ụgbọala nke nrụgide oxidative (OS), ọ bụghị ihe ijuanya na nrụgide oxidative bụ akụkụ nke ihe na-ebute usoro ọrịa na ọrịa Alzheimer (AD).
N'ezie, nnukwu ihe akaebe na-egosi na OS na-eme tupu apụta ihe mgbaàmà na AD yana na a na-achọpụta mmebi oxidative ọ bụghị naanị na mpaghara ụbụrụ na-adịghị ike kamakwa na mpaghara mpaghara.
Sharma, C., na Kim, SR (2021). Na-ejikọta nrụgide oxidative na proteinopathy na ọrịa Alzheimer. antioxidants, 10(8), 1231. https://doi.org/10.3390/antiox10081231
Maka ndị ọhụrụ n'okwu a, nrụgide oxidative na-akọwa ahaghị nhata nke na-eme n'ahụ anyị n'etiti ụmụ irighiri ihe na-emerụ ahụ nke a na-akpọ ụdị oxygen reactive (ROS) na ikike anyị nwere ịgbachitere ha. Ị pụghị ịdị ndụ ma ghara ime ROS, n'ihi na ha bụ akụkụ nkịtị nke metabolism, ma na ụbụrụ Alzheimer, nrụgide oxidative na-apụ na chaatị ahụ, na ụbụrụ enweghị ike ịlụso ya ọgụ na-ebute ọganihu ọrịa, na-emebi akwara anyị. protein na DNA. Mmebi a bụ ihe anyị na-ezo aka dị ka nrụgide oxidative. Ma gịnị ka nrụgide oxidative dị ka mgbe ọ na-eme na ụbụrụ? Ọ dị ka lipid peroxidation na protein na-ezighị ezi.
Ndị na-anya nrụgide Oxidative na Alzheimer
Lipid peroxidation bụ otu n'ime ihe na-esikarị na nrụgide oxidative pụta. Ọ na-emebi neurons nke ukwuu n'ihi na akpụkpọ ahụ plasma ha nwere nnukwu acid fatty polyunsaturated. Polyunsaturated ọdụdụ asịd na-enwe ike oxidation. Usoro a na-agbanwe njirimara nke akpụkpọ ahụ cell, na-emetụta mmiri ya, permeability, na ọrụ nke protein na-ejikọta akpụkpọ ahụ. Nke a na-arụ ọrụ neuronal dị oke mkpa yana ikike nke neuron iji kparịta ụka.
Protein oxidation na-eduga n'ịgbanwe nhazi na ọrụ protein. Nke a nwere ike ịkpaghasị ọrụ enzyme na ọrụ nnabata, na-egbochi usoro biochemical na metabolic nkịtị nke neurons.
Kedu ihe anyị na-ahụ na ụbụrụ Alzheimer, na-alụso oke nrụgide oxidative ọgụ?
Nchegbu oxidative nwere ike ime ka mmepụta na mkpokọta amyloid-beta ka njọ. Nke a peptide nwere ike ịkpata nrụgide oxidative n'onwe ya, na-emepụta usoro mmebi ahụ jọgburu onwe ya. Ọzọkwa, protein na lipids mebiri emebi na-enwekarị ike imepụta mkpokọta, nke nwere ike ime ka mpụta amyloid-beta plaques ka njọ.
Ọrụ nke nrụgide oxidative pụtakwara ìhè na hyperphosphorylation nke tau, njirimara ọzọ nke Alzheimer. N'okpuru ọnọdụ nke nrụgide oxidative, enwere mmụba nke ọtụtụ kinase (enzymes na-agbakwunye otu phosphate na protein ndị ọzọ), nke nwere ike iduga tau hyperphosphorylation. Hyperphosphorylated tau na-adịkarị mfe nchịkọta, na-eduga n'ịmepụta neurofibrillary tangles, akara ọzọ nke AD.
Na mgbakwunye, nrụgide oxidative nwere ike ibute ọnwụ neuronal na AD site na usoro a na-akpọ apoptosis ma ọ bụ ọnwụ cell emebere. Ikpughe oge na nrụgide oxidative nwere ike ịkpalite ụzọ a, na-eduga na mfu nke neurons na mmụba nke mgbaàmà ọgụgụ isi.
Proteinopathy na oke mmepụta nke ụdị oxygen na-emeghachi omume (ROS), nke bụ njirimara ndị bụ isi a na-ahụ na ụbụrụ ọrịa Alzheimer (AD), na-enye aka na nsị neuronal.
Sharma, C., na Kim, SR (2021). Na-ejikọta nrụgide oxidative na proteinopathy na ọrịa Alzheimer. antioxidants, 10(8), 1231. https://doi.org/10.3390/antiox10081231
Ka m kwuo nke ahụ ọzọ, n'ụzọ ọzọ, ọ bụrụ na nke ahụ adaghị gị n'ụlọ.
Nchegbu oxidative abụghị naanị na-ekere òkè na-akwado ọrịa Alzheimer. Nke a abụghị naanị njikọ a na-ahụ na akwụkwọ sayensị. Nchegbu oxidative na ụbụrụ Alzheimer bụ ike dị ike na nke aghụghọ na-arụsi ọrụ ike na-ebute mmepe na ọganihu ọrịa ahụ. Ọchịchị ya a na-achịkwaghị achịkwa na-akpalite ma na-eme ka ọdịda ụbụrụ dị ngwa ngwa, na-eme ka ọ dịkwuo njọ n'akwụsịghị akwụsị nke na-egosi ọrịa Alzheimer.
Nchegbu oxidative na-achịkwaghị achịkwa na-akpali ihe omume neurochemical na-eduga na nguzobe nke njirimara Alzheimer: amyloid-beta plaques na tau tangles.
Kedu ihe kpatara na-ejighị n'aka nrụgide oxidative na ụbụrụ Alzheimer? N'ihi na ọgwụ ndị anyị na-emepụta maka ọrịa ahụ adịghị alaghachi azụ azụ na agbụ ihe kpatara iji nye anyị ihe ọ bụla anyị ga-atụ anya ya. Ha anaghị edozi ike ụbụrụ. Ha anaghị eleba anya n'ọgba aghara nke nrụgide oxidative nke na-abịa n'ọtụtụ ọnọdụ nke ọrịa Alzheimer site na nsogbu nke ike ụbụrụ.
Ọ dabara nke ọma, anyị nwere nri ketogenic dị n'aka anyị iji nyere aka ịlụso nrụgide oxidative ọgụ na ụbụrụ ọrịa Alzheimer.
Mana kedu usoro nke nri ketogenic si eme nke a?
Nri Ketogenic na-ebelata nrụgide Oxidative
Nke mbụ, ịba ụba ume ụbụrụ na imeziwanye nọmba mitochondrial na ọrụ nke bụ akụkụ nke nri ketogenic, bụ nnukwu uru iji lụso nrụgide oxidative ọgụ. Neurons chọrọ ume iji rụọ ọrụ bụ isi na idobe sel! Kedu ka ị dị mma n'ịrụ ọrụ ma ọ bụ ọrụ gị mgbe ị na-enweghị ume? Ọ dịghị mma? Ihe na-agbakọta, na ihe na-emechabeghị ma ọ bụ na-emeghị nke ọma? Kpọmkwem. Ụbụrụ gị chọrọ nnapụta ike nke na-eme na nri ketogenic iji mee ka nrụgide oxidative na-elele ma jikwaa nguzozi n'etiti nrụgide oxidative na ROS na ụbụrụ.
β-hydroxybutyrate (BHB), bụ isi ketone ahụ emepụtara n'oge ketosis, achọpụtala na ọ nwere ihe ndị na-egbochi ọrịa. A na-enweta mbelata na ROS site n'ịkwalite arụmọrụ nke yinye njem elektrọn na mitochondria, ibelata ntapu elektrọn na, emesịa guzobe ROS. Site n'iwetu mmepụta ROS n'ozuzu ya, BHB nwere ike ibelata ibu nrụgide oxidative n'ụzọ na-edoghị anya.
Mana nri ketogenic nwere ụzọ ndị ọzọ dị ike nke ọ na-enyere aka belata nrụgide oxidative. E gosiputara nri ketogenic ka ha nwee ike ịbawanye ike endogenous (mere n'ime ahụ anyị) antioxidant a maara dị ka glutathione (GSH).
Ọnụ, nsonaazụ na-egosi na KD na-achịkwa GSH biosynthesis, na-akwalite ọkwa antioxidant mitochondrial, ma na-echebe mtDNA site na mmebi nke oxidant.
Jarrett, SG, Milder, JB, Liang, LP, & Patel, M. (2008). Nri ketogenic na-abawanye ọkwa mitochondrial glutathione. Akwụkwọ akụkọ neurochemistry, 106(3), 1044-1051. https://doi.org/10.1111/j.1471-4159.2008.05460.x
Mmụba nke mmepụta glutathione anyị na-ahụ na nri ketogenic nwere ike ịbụ n'ihi na ketosis na-akwalite mmepụta NADPH, coenzyme nke na-arụ ọrụ dị mkpa na mweghachi nke glutathione. Mgbe mkpụrụ ndụ nwere NADPH zuru oke, ha nwere ike ịtụgharị oxidized glutathione (GSSG) nke ọma n'ụdị ya belatara, nke na-arụ ọrụ (GSH), si otú a na-ejigide nchebe antioxidant siri ike.
… ụbara mmepụta nke antioxidants (dịka GSH) na detoxification Enzymes nke nwere ike dị oke egwu n'ịgbazi mmetụta nchebe nke KD.
Milder, J., & Patel, M. (2012). Mgbanwe nke nrụgide oxidative na ọrụ mitochondrial site na nri ketogenic. Nchọpụta ọrịa epilepsy, 100(3), 295-303. https://doi.org/10.1016/j.eplepsyres.2011.09.021
Site n'ịkwado mmepụta na mmeghari nke glutathione, BHB na-enyere aka ịnọgide na-enwe ọdọ mmiri nke na-arụ ọrụ, belata glutathione dị njikere ịkwụsị ROS ma belata nrụgide oxidative site n'igosipụta ihe onwunwe antioxidant nke onwe ya. Mmekọrịta symbiotic a dị n'etiti BHB na glutathione na-arụ ọrụ iji mee ka nchebe antioxidant sie ike, karịsịa dị mkpa na ụbụrụ ebe nrụgide oxidative nwere ike inwe mmetụta na-agbawa obi.
Kedu ihe kpatara na anyị agaghị eji nri ketogenic dị ka ihe nchebe nke mbụ megide mbibi nke nrụgide oxidative? Kedu ihe kpatara na nke a agaghị abụ ọgwụgwọ dị ike nke nhọrọ, karịsịa n'ime ọnọdụ nke mmetụta na-adịghị mma nke na-adịghị mma na ọganihu ọrịa Alzheimer a na-enye dị ka usoro nlekọta anyị ugbu a?
Ịgbakọta ọmụmụ ihe gbasara ahụike na ụlọ ọgwụ egosila na KD bara uru na AD. Usoro nwere ike ime na-agụnye ọrụ mitochondrial ka mma, njikarịcha ihe mejupụtara gut microbiota, yana mbelata neuroinflammation na nrụgide oxidative.
Xu, Y., Zheng, F., Zhong, Q., & Zhu, Y. (2023). Nri Ketogenic dị ka ntinye aka na-abụghị ọgwụ na-ekwe nkwa maka ọrịa Alzheimer: usoro na ihe ọ pụtara. Akwụkwọ nke Ọrịa Alzheimer, (Mbipụta), 1-26. https://content.iospress.com/articles/journal-of-alzheimers-disease/jad230002
Ọ bụ na nnapụta nke ike ụbụrụ site na isi iyi mmanụ ọzọ, mmụba mitochondrial biogenesis, na mma antioxidant Njirimara iji belata nrụgide oxidative agaghị ezuru ịhọrọ usoro ọgwụgwọ metabolic a maka ụbụrụ dịka ọgwụgwọ nke afọ maka mgbaka? Ọ ga- Ma kwere ya ma ọ bụ na ị kwenyeghị, enwere mmetụta pleiotropic karịa nri ketogenic nke ị ga-achọ ịma.
Mmetụta Neurotransmitter na Alzheimer: Mmetụta Keto
Ọgwụ ndị na-etinye aka naanị na nguzozi nke neurotransmitter na ọkwa ọrụ bụ, n'eziokwu, na-efu oke ọhịa maka osisi. Ha na-elekwasị anya na njedebe ikpeazụ nke usoro ogologo oge, nke na-eme ka ọ dị ogologo na-enweghị nlebara anya n'adịghị arụ ọrụ nke elu na mitochondria, metabolism, na usoro nrụgide oxidative nke na-akwalite ọganihu pathological na ọrịa Alzheimer. Mana ị nwere ike ịmasị etu nri ketogenic ga-esi nyere aka na nsogbu neurotransmitter anyị na-ahụ na-etolite na Alzheimer, yabụ ka anyị gaa n'ihu na-amụ ihe!
Ya mere, ka anyị laghachi azụ n'ịtụle ihe efu nke ọgwụ na-elekwasị anya na nsogbu neurotransmitter a na-ahụ na ọrịa Alzheimer ma na-aga n'ihu na nghọta anyị banyere otú nri ketogenic si bụrụ nhọrọ dị elu iji mesoo ha ozugbo ha mere.
Debe aka na Glutamate gị
Cheta site n'ọgụgụ gị na mbụ na post a na ndị na-emegide ndị na-anabata NMDA dị ka Memantine (Namenda) bụ ọgwụ edepụtara na mbọ iji hazie ọrụ glutamate. Ọ dị otu a ka nri ketogenic nwere mmetụta dị ike na-enweghị mmetụta ọ bụla.
Achọpụtala na acetone na β-hydroxybutyrate (βHB) na-arụ ọrụ dị ka ndị na-egbochi glutamate na onye na-anabata NMDA, na-egosipụta kpọmkwem ọrụ βHB gosipụtara.
Pflanz, NC, Daszkowski, AW, James, KA, & Mihic, SJ (2019). Mgbanwe ahụ Ketone nke ọwa ion ligand-gated. Neuropharmacology, 148, 21-30. https://doi.org/10.1016/j.neuropharm.2018.12.013
Kedu ihe kpatara na anyị agaghị etinye nri ketogenic maka nzube a ma zere mmetụta dị n'akụkụ nke dizziness, isi ọwụwa, na mgbagwoju anya nke bụ akụkụ nke ọgwụ ndị a?
KD nwere ike inye uru ọgwụgwọ na ndị ọrịa nwere nsogbu akwara ozi site na ịchịkwa nguzozi n'etiti usoro pro- na antioxidant yana pro-excitatory na inhibitory neurotransmitters.
Pietrzak, D., Kasperek, K., Rękawek, P., & Piątkowska-Chmiel, I. (2022). Ọrụ ọgwụgwọ nke nri ketogenic na nsogbu akwara ozi. Nri, 14(9), 1952. https://doi.org/10.3390/nu14091952
Nri Ketogenic na-agbanwe GABA
Ọ bụghị ihe niile gbasara ibelata ọkwa glutamate na-egbu egbu, n'agbanyeghị. Ekwesịrị inwe nguzozi n'etiti neurotransmitter glutamate na-egbochi neurotransmitter gamma-aminobutyric acid (GABA). Otu n'ime isi mmetụta nke nri ketogenic na kemịka ụbụrụ gụnyere (GABA), bụ isi ihe na-egbochi neurotransmitter na ụbụrụ. Nnyocha egosila na ahụ ketone nwere ike ịbawanye mmepụta ụbụrụ nke GABA. Nke a dị mkpa maka ọrịa Alzheimer n'ihi na mgbaàmà GABAergic na-enwekarị nsogbu na ndị ọrịa Alzheimer, yana imezi ụda GABAergic nwere ike inye aka weghachite nguzozi na netwọkụ akwara nke ọrịa ahụ mebiri.
Nke a na-ebute mmụba nke mmepụta ATP na mgbanwe na njikọ nke β-aminobutyric acid (GABA: neurotransmitter kachasị ike na-egbochi) na glutamate (onye bụ isi na-akpali akpali).
Murakami, M., & Tognini, P. (2022). Usoro molecular na-akpata ihe ndị na-akpata bioactive nke nri ketogenic. Nri, 14(4), 782. https://doi.org/10.3390/nu14040782
Ọzọkwa, cheta na na mmalite, anyị tụlere iji otu klas nke ọgwụ a maara dị ka ndị na-egbochi Cholinesterase. Ebumnuche nke ọgwụ ndị a bụ iji belata nkwụsị nke acetylcholine, neurotransmitter na-ebelatakarị na ndị ọrịa Alzheimer.
Ma gịnị banyere acetylcholine?
Acetylcholine bụ neurotransmitter nke na-arụ ọrụ dị mkpa na ebe nchekwa na mmụta ma na-ebelata nke ọma na ọrịa Alzheimer. Ọ bụ ezie na nri ketogenic anaghị abawanye ọkwa acetylcholine ozugbo, ọ na-akwado ahụike ụbụrụ n'ụzọ na-enyere aka ichekwa ọrụ acetylcholine. Site na ibelata nrụgide oxidative na ịkwado ọrụ mitochondrial, nri ketogenic na-echebe neurons cholinergic (neurons nke na-eji acetylcholine na-ebufe akara) site na mmebi.
Yabụ ịmara na nrụgide oxidative na mitochondria mebiri emebi nwere ike imebi ntọhapụ acetylcholine na ndị na-anabata ya, kedu ka anyị ga-esi kwalite ọrụ mitochondrial ma belata nrụgide oxidative site na usoro dị ike dị na nri ketogenic? Echere m na anyị nwere ike ịhụ ọkwa acetylcholine ka mma na ndị ọrịa Alzheimer na-enweghị mmetụta ọgbụgbọ, ọgbụgbọ, na afọ ọsịsa.
Mbelata Neuroinflammation na Ọrịa Alzheimer: Mmetụta ọgwụgwọ Ketosis
Neuroinflammation na-eme mgbe usoro ahụ ji alụso ọrịa ọgụ na-agbalị ichebe ụbụrụ gị pụọ na ọrịa, mmerụ ahụ, ma ọ bụ nchịkọta protein na-adịghị mma. Mgbe mmeghachi omume mgbochi na-ebute na ụbụrụ, microglia na astrocytes na-awakpo ihe iyi egwu ahụ. Na ka ha na-awakpo ihe iyi egwu ahụ, ha na-apụta ma hapụ ụyọkọ cytokines na-akpasu iwe. Dịkwa ka n'ịgba égbè, ụfọdụ mgbọ ga-efegharị n'ụzọ na-edoghị anya, na ụfọdụ mmebi iwu ga-eme.
Ọ bụrụ na a na-edozi ọkwa nrụgide oxidative gị nke ọma, ụbụrụ nwere ike wughachi ma mezie site na usoro a; ọ bụrụ na ọ bụghị, ọ gaghị eme. N'ụzọ dị otú a, neuroinflammation na-enyere aka ịchụpụ usoro neurodegenerative.
Mgbe neuroinflammation na-aghọ nke na-adịghị ala ala na nke na-adịghị agwụ agwụ, ọ ga-agbanwe n'ụzọ nkịtị otú microglia si akpa àgwà (morphology) ma mee ka ha "na-akpali akpali" na ime ihe ike na omume ha na-emeso mwakpo. Mgbe n'ọnọdụ a na-emebiga ihe ókè, microglia ga-amalite iri ma bibie neuron ndị na-arịa naanị ọrịa ma nwee ike ịzọpụta!
Ị nwere ike iche n'echiche ka usoro ahụ ji alụso ọrịa ọgụ na-adịghị arụ ọrụ nke ọma, ihe mgbochi ụbụrụ ụbụrụ gbajiri agbaji (BBB) na-enweghị ike ichebe ụbụrụ, ma ọ bụ nnukwu nrụgide oxidative n'ihi glucose hypometabolism (ike ụbụrụ dara ogbenye) ma ọ bụ ụkọ micronutrient nwere ike ime ka ọ bụrụ ihe na-adịghị akwụsị akwụsị nke neuroinflammation. . Na enweghị atụ, ọ nwere ike inye aka na mmepe na ọganihu nke ọrịa neurodegenerative, gụnyere ọrịa Alzheimer.
Neuroinflammation bụ otu n'ime ihe ndị bụ isi nke ọrịa Alzheimer.
Thakur, S., Dhapola, R., Sarma, P., Medhi, B., & Reddy, DH (2023). Neuroinflammation na ọrịa Alzheimer: ọganihu ugbu a na akara ngosi ihe omimi na ọgwụgwọ. mbufụt, 46(1), 1-17. https://doi.org/10.1007/s10753-022-01721-1
Ọ bụrụ na ị ka na-enwe ntakịrị mgbagwoju anya banyere ọdịiche dị n'etiti neuroinflammation na nrụgide oxidative na otu esi ejikọta ha, ị nwere ike ịhụ isiokwu a n'okpuru na-enye aka.
Tupu anyị abanye na usoro nke nri ketogenic na-ebelata neuroinflammation, ka anyị nyochaa nghọta anyị ruo ugbu a.
Ketones na-amụba ụbụrụ ma napụta ike ụbụrụ. Ọ bụrụ na agụụ na-agụ ụbụrụ ụbụrụ ike, ọ na-enwe nrụgide ma na-akpali akpali. Nchegbu oxidative na-aga n'elu ụlọ, micronutrients na-agwụkwa ike na-agbalị idobe ihe. Ndị neurotransmitters na-aghọ ndị na-adịghị mma (na neurotoxic na ahaghị nhata ha; cheta Glutamate?), Na ndị na-anabata neurotransmitter ha na-agbaji ma na-akpaghasị ụzọ nkwurịta okwu chọrọ maka nlekọta na ọrụ. Neuroinflammation na-apụta ma na-ebute ya site na nzaghachi nzaghachi na-adịghị akwụsị akwụsị wee rute ọnọdụ na-adịghị ala ala na ụbụrụ.
Anyị mụtakwara na ahụ ketone nwere ike ịkwalite ikike antioxidant nke ụbụrụ ozugbo na na-apụtaghị ìhè. Ma ọ bụrụ na nke ahụ bụ, a kwụsịrị uru nri ketogenic? Ọ bụrụ na nke ahụ bụ "niile" nri ketogenic nwere ike inye usoro ụbụrụ neurodegenerative dị ka ọrịa Alzheimer, nke ahụ ọ gaghị ezu? Ọ bụ na ahụ agaghị adị anyị mma nke ukwuu na ọ dị ihe ga-enyere usoro ọrịa ahụ niile aka ka mma?
Anyị ga-! Ma anyị bụ! Mana ndị ahụ abụghị naanị ụzọ nri ketogenic na-enyere aka ịlụ ọgụ neuroinflammation. Blọọgụ a nwere ike kwụsị ebe ahụ. Mana achọrọ m ka ị ghọta ọtụtụ mmetụta pleiotropic nri ketogenic nwere na ahụike ụbụrụ, yabụ enwere m ike nweta ya n'isi onye ọ bụla na anyị enweghị ọgwụ na-eme ọbụlagodi obere akụkụ nke a!
Taming Microglia: Uru akwara na-adịghị ahụ anya nke Ketogenic
Dị ka a tụlere na mbụ, mkpụrụ ndụ microglial na-arụ ọrụ dị oke mkpa na neuroinflammation.
A na-ejikọta Neuroinflammation na microglia activation na ụbara ntọhapụ nke ihe mkpali dị ka tumor necrosis factor (TNF), interleukins (IL-1β, IL-6) na free radicals, nke nwere ike ịkpata nkwụsị ọrụ na-aga n'ihu ma ọ bụ ọnwụ cell na ụbụrụ.
Pietrzak, D., Kasperek, K., Rękawek, P., & Piątkowska-Chmiel, I. (2022). Ọrụ ọgwụgwọ Ketogenic nri na nsogbu akwara ozi. Nri nri, 14(9), 1952. https://doi.org/10.3390/nu14091952
Keto: Nna-ukwu na-ahụ maka ụzọ mkparị
Enwere ọtụtụ usoro dị iche iche nke nri ketogenic na-alụ ọgụ mbufụt, yana nsonaazụ ya dị ka ahụ na-egosi mkpụrụ ndụ na ụzọ mkpasu iwe dị iche iche bụ n'ezie otu n'ime ha niile!
Mmetụta nri Ketogenic na NLRP3 inflammasome
Nke mbụ, BHB (otu n'ime ahụ ketone ndị a na-eme na nri ketogenic) na-egbochi ihe a na-akpọ NLRP3 inflammasome. Nke a bụ ihe mgbagwoju anya protein nke na-arụ ọrụ dị mkpa na nzaghachi mgbochi na mbufụt. Mgbe microglia na ụdị sel ndị ọzọ na-arụ ọrụ, ọ na-ebute ntọhapụ nke cytokines pro-inflammatory dị ka IL-1β na IL-18, nke na-enye aka na usoro mkpali na ahụ.
Nri ketogenic na-ekere òkè na igbochi usoro a. Site n'igbochi NLRP3 inflammasome, BHB na-enyere aka belata ntọhapụ nke cytokines pro-inflammatory ma mebie nzaghachi mkpali.
E kwubiri na KD gbochiri nzaghachi mkpali nke OA site na NLRP3 inflammasome, si otú ahụ na-echebe cartilage articular. The inflammasome bụ protein mgbagwoju a chọtara na cytoplasm, na ọ na-etinye aka na nhazi nke nzaghachi mkpali.
Kong, G., Wang, J., Li, R., Huang, Z., & Wang, L. (2022). Nri ketogenic na-eme ka ọzịza dị mma site na igbochi NLRP3 inflammasome na osteoarthritis. Nnyocha na ọgwụgwọ ọrịa ogbu na nkwonkwo, 24(1), 113. https://doi.org/10.1186/s13075-022-02802-0
BHB nwere ike igbochi NLRP3 inflammasome site n'ọtụtụ usoro. Ọ na-egbochi mgbakọ nke NLRP3 inflammasome complex, na-egbochi ọrụ ya. Ọ na-egbochi mmepụta nke cytokines pro-inflammatory dị ka IL-1β site na ibelata ọrụ nke mkpali ahụ. Ma ọ nwere ike gbanwee ọrụ nke ihe ntụgharị ederede NF-κB, nke na-achịkwa okwu nke mkpụrụ ndụ ihe nketa na-etinye aka na mbufụt.
Ka anyị gụọ ahịrịokwu ikpeazụ ahụ ọzọ. Ọ na-achịkwa okwu nke mkpụrụ ndụ ihe nketa na-etinye aka na mbufụt. Gosi m ọgwụ maka ọrịa Alzheimer na-eme nke ahụ nke ọma.
Igodo ketogenic maka HCA2
Ọrụ ọzọ beta-hydroxybutyrate (BHB) na-arụ, ketone emepụtara na nri ketogenic, bụ mmekọrịta ya na onye nnabata a na-akpọ Hydroxycarboxylic Acid Receptor 2 (HCA2) ma ọ bụ G-protein jikọtara 109A (GPR109A). Ahụ ketone a na-ejikọta ma rụọ ọrụ HCA2 na na-eziga mgbama n'ime cell iji belata mbufụt.
Ugbu a, ka anyị kwuo banyere prostaglandins. Prostaglandins bụ kemịkalụ na ahụ anyị na-ekere òkè na mbufụt. Ha na-eme ihe dị ka ndị ozi na-ebuga n'ime mkpụrụ ndụ ihe mgbaàmà, na-agwa ha ka ha nwee ọkụ. BHB na-ebelata mmepụta nke prostaglandins ndị a. Mgbe BHB na-eme ka HCA2 rụọ ọrụ, ọ na-eziga ozi na mkpụrụ ndụ ka ọ kwụsị izipu ozi ederede mkpasu iwe. N'ikwu ya n'ụzọ ọzọ, BHB na-arụ ọrụ dị ka bọtịnụ "ogbi" maka mkpụrụ ndụ, na-egbochi ha ịhapụ ọtụtụ ozi na-akwalite mbufụt.
Site n'ibelata mmepụta nke prostaglandins na imebi nzaghachi mkpali, BHB na-enyere aka ịchịkwa mbufụt na ahụ. Nke a bụ otu ụzọ nri ketogenic, yana mmụba ya nke BHB, nwere ike nwee mmetụta mgbochi mkpali.
Nri Ketogenic: Akwụsị-ụbụrụ Axis Transformer maka ịlụ ọgụ ọgụ
A na-eche na microbiome gut na-emetụta ọganihu ọrịa Alzheimer. A na-eche na ọ ga-eme nke a site na mmepụta microbiome nke metabolites, mmetụta na neurotransmitters, mgbanwe nke usoro ahụ ji alụso ọrịa ọgụ na mbufụt, na mmetụta nwere ike na iguzosi ike n'ezi ihe nke mgbochi ụbụrụ ọbara (BBB).
Ọrụ nke gut microbiota na GMBA [gut microbiota-brain axis] na AD bụ ihe kacha mkpa. Ngwakọta nke nje bacteria na-emetụta n'ụzọ dị egwu ọ bụla ọrịa akwara ozi metụtara afọ, dị ka AD, na nsogbu ọnọdụ ọnọdụ.
Varesi, A., Pierella, E., Romeo, M., Piccini, GB, Alfano, C., Bjørklund, G., Oppong, A., Ricevuti, G., Esposito, C., Chirumbolo, S., & Pascale, A. (2022). Ọrụ puru omume nke Gut Microbiota na Ọrịa Alzheimer: Site na Nchọpụta ruo Ọgwụgwọ. Nri, 14(3), 668. https://doi.org/10.3390/nu14030668
Nri ketogenic na-eduga na mgbanwe dị ukwuu na microbiome gut. Ọ na-akwalite uto nke nje bacteria bara uru ma na-ebelata ịba ụba nke ụmụ nje ndị nwere ike imerụ ahụ. A na-ahụ mgbanwe a n'ime ihe mejupụtara microbial ka ọ na-emetụta ọrụ ụbụrụ yana mbufụt site na axis-ụbụrụ nke ukwuu.
Gịnị kpatara? N'ihi na eriri afọ microbiome na-emepụta metabolites dị iche iche na ụmụ irighiri ihe na-egosi nke nwere ike imekọrịta usoro ụjọ ahụ. Ụmụ irighiri ihe ndị a nwere ike imetụta ọrụ ụbụrụ ozugbo ma gbanwee usoro mkpali. Enwere ike ịgbazite ikike nri ketogenic iji belata mbufụt, opekempe n'akụkụ ya, site na mmetụta ya na eriri afọ microbiota. Ọ bụ naanị otu usoro ọzọ nke nri ketogenic na-enyere aka ịlụso neuroinflammation ọgụ ma gbanwee naanị otu usoro ọrịa na-akpata nke a na-ahụ na dementia Alzheimer.
Kedu ihe kpatara na anyị agaghị eji ntinye aka na-akwalite ọnọdụ mkpali dị mma n'ụbụrụ n'ime onye na-arịa usoro neurodegenerative dị ka ọrịa Alzheimer?
Ngwakọta nke microbiota nwere ike imetụta mmepe yana igbochi ọrịa na-aga n'ihu, ma nwee ike ịnọchite anya usoro ọgwụgwọ ọzọ nwere ike ime maka nsogbu akwara ozi.
Pietrzak, D., Kasperek, K., Rękawek, P., & Piątkowska-Chmiel, I. (2022). Ọrụ ọgwụgwọ nke nri ketogenic na nsogbu akwara ozi. Nri, 14(9), 1952. https://doi.org/10.3390/nu14091952
Ọ bụrụ na ịchọrọ ịghọta mmetụta nri ketogenic na ụfọdụ ihe ndị ọzọ metụtara microbiome ndị a tụlere na ngalaba a, biko hụ isiokwu ndị ọzọ n'okpuru tupu ịga n'ihu na nkwubi okwu.
Na mmechi: Ọrịa Alzheimer na ọrụ dị mkpa nke nri Ketogenic
Ya mere, nri ketogenic ọ ga-edozi usoro ọgwụgwọ niile dị n'okpuru bụ akụkụ nke ndị ị hụrụ n'anya (ma ọ bụ) mbelata ọgụgụ isi? Ikekwe. Ma eleghị anya ọ bụghị. Ọ bụrụ na ibu ígwè dị arọ na-ebutekwu nrụgide oxidative, ikpughe nsí nsí ebu, ọrịa zoro ezo, ma ọ bụ ọtụtụ ihe ndị ọzọ, ọ ga-abụ na ị ga-achọ ma ọ bụ chọọ enyemaka ọzọ. Enwere ike ịkpalite ọganihu ọrịa site na ezughị oke ma ọ bụ ụkọ nke micronutrients dị mkpa nke mitochondria kwesịrị ime nke ọma.
E nwere ihe dị iche iche ịkwọ ụgbọala maka ọrịa Alzheimer na phenotypes dị iche iche. Ebumnuche nke isiokwu a abụghị ịrụ ụka ma ọ bụ arụrịta ụka ma nri ketogenic ga-edozi usoro ọgwụgwọ ọrịa niile nke bụ akụkụ nke ọganihu ọrịa onye ọ bụla.
Isi na ebumnuche nke isiokwu a bụ igosi gị na nri ketogenic bụ nhọrọ ọgwụgwọ kachasị zuru oke na nke neuroprotective anyị nwere. Iji gwa gị okwu nke ọma na ọ bụrụ na ihe ọ bụla nwere ohere ịkwụsị ma ọ bụ belata ọganihu nke ọrịa Alzheimer site na ọtụtụ usoro nkwado, ọ bụ, n'eziokwu, nri ketogenic.
N'ikpeazụ, e dere akụkọ a iji nwee olile anya mebie echiche na-ezighi ezi na ọgwụgwọ ndị dọkịta na-ahụ maka akwara gị nyere iwu na-anọchite anya naanị ụzọ maka ime ihe a kọwara n'ụzọ na-ezighi ezi dị ka amụma siri ike na nke na-enweghị mgbagha. Ejighị m n'aka na nke ahụ bụ mgbe a na-enye ihe ndị a dị n'okpuru ebe a kọwara na post a ohere itinye aka dị ike dị ka nri ketogenic. Ma ọ dịkarịa ala, n'ọtụtụ ọnọdụ, echere m na ọ ga-ekwe omume ịkwụsịlata ọganihu.
Anọla n'oche, na-echere ndị ọkachamara ahụike ka ha nweta ọsọ ọsọ nke nchọpụta sayensị mgbe ụbụrụ gị ma ọ bụ onye ị hụrụ n'anya na-aga n'ihu na neurodegenerate ruo n'ókè nke nlọghachi.
Ị nwere ike ịrụ ọrụ na onye na-eri nri ma ọ bụ ọkachamara n'ihe oriri na-edozi ahụ nke zụrụ ketogenic iji nyere ha aka (ma ọ bụ onwe gị). Ọ bụrụ na ị nwere nrịanrịa dị nro nke mbụ (MCI) ma ọ bụ Alzheimer na-esote ma nwee nkwado nke onye nlekọta, ị nwere ike ịchọta nkwado na rite uru na ya. mmemme ịntanetị m.
N'agbanyeghị ebe ị kpebiri ịga maka enyemaka, echela.
Abịara m ebe a ịgwa gị na ọ dịghị onye ga-anapụta gị ma ọ bụ onye ị hụrụ n'anya n'agba mgbaka. Omume nke itinye n'ọrụ nri ketogenic nwere ike ime, yana nkwado dị ukwuu n'ebe ahụ.
Ana m ezitere gị ịhụnanya na njem gị.
Ọ bụrụ na ị na-achọ ozi gbasara ketones exogenous ị nwere ike ịhụ akụkọ ndị a na-enye aka.
References
Achanta, LB, & Rae, CD (2017). β-Hydroxybutyrate n'ime ụbụrụ: Otu Molecule, ọtụtụ usoro. Nnyocha Neurochemical, 42(1), 35-49. https://doi.org/10.1007/s11064-016-2099-2
Almulla, AF, Supasitthumrong, T., Amrapala, A., Tunvirachaisakul, C., Jaleel, A.-KKA, Oxenkrug, G., Al-Hakeim, HK, & Maes, M. (2022). Ụzọ Tryptophan Catabolite ma ọ bụ Kynurenine na Ọrịa Alzheimer: Nyocha nhazi na Meta-Analysis. Akwụkwọ nke Ọrịa Alzheimer, 88(4), 1325-1339. https://doi.org/10.3233/JAD-220295
Altayyar, M., Nasser, JA, Thomopoulos, D., & Bruneau, M. (2022). Mmetụta Ketosis nke anụ ahụ na ụbụrụ ọgụgụ isi: Nyochaa akụkọ. Nri, 14(3), Nkeji edemede 3. https://doi.org/10.3390/nu14030513
Alves, F., Kalinowski, P., & Ayton, S. (2023). Mfu Mpịakọta Ụbụrụ Ọsọ nke Ngwọta Anti-β-Amyloid kpatara: Nleba Nleba anya na Meta-analysis. Nchọpụta ihe, 100(20), e2114 – e2124. https://doi.org/10.1212/WNL.0000000000207156
Ihe mgbaàmà Alzheimer: Mgbanwe ụbụrụ. (nd). Eweghachitere Mee 21, 2023, site na https://www.healthline.com/health-news/can-alzheimers-be-detected-30-years-before-it-appears
Ardanaz, CG, Ramírez, MJ, & Solas, M. (2022). Mgbanwe Ụbụrụ Metabolic na Ọrịa Alzheimer. Akwụkwọ bụ International Journal of Scholarships, 23(7), Nkeji edemede 7. https://doi.org/10.3390/ijms23073785
Bohnen, JLB, Albin, RL, & Bohnen, NI (2023). Ntinye aka Ketogenic na nhụsianya dị nro, ọrịa Alzheimer, na ọrịa Parkinson: nyocha usoro na nyocha dị oke egwu. Ala dị ala na Neurology, 14, 1123290. https://doi.org/10.3389/fneur.2023.1123290
Costantini, LC, Barr, LJ, Vogel, JL, & Henderson, ST (2008). Hypometabolism dị ka ebumnuche ọgwụgwọ na ọrịa Alzheimer. Ahụhụ BMC, 9(Nkwanye 2), S16. https://doi.org/10.1186/1471-2202-9-S2-S16
Croteau, E., Castellano, CA, Fortier, M., Bocti, C., Fulop, T., Paquet, N., & Cunnane, SC (2018). Ntụle akụkụ nke glucose ụbụrụ na metabolism ketone n'ime ndị okenye nwere ahụike nwere uche, adịghị ike nghọta dị nro na ọrịa Alzheimer n'oge. Ahụmahụ Gerontology, 107, 18-26. https://doi.org/10.1016/j.exger.2017.07.004
Cullingford, TE (2004). nri ketogenic; fatty acids, ndị na-anabata fatty acid na-arụ ọrụ na nsogbu akwara ozi. Prostaglandins, Leukotrienes na Ihe dị mkpa Acid Acids, 70(3), 253-264. https://doi.org/10.1016/j.plefa.2003.09.008
Cunnane, S., Nugent, S., Roy, M., Courchesne-Loyer, A., Croteau, E., Tremblay, S., Castellano, A., Pifferi, F., Bocti, C., Paquet, N ., Begdouri, H., Bentourkia, M., Turcotte, E., Allard, M., Barberger-Gateau, P., Fulop, T., & Rapoport, S. (2011). METABOLISM mmanụ ụbụrụ ụbụrụ, ịka nká na ọrịa ALZHEIMER. Nri (Burbank, Los Angeles County, Calif.), 27(1), 3-20. https://doi.org/10.1016/j.nut.2010.07.021
Dilliraj, LN, Schiuma, G., Lara, D., Strazzabosco, G., Clement, J., Giovannini, P., Trapella, C., Narducci, M., & Rizzo, R. (2022). Evolushọn nke Ketosis: Mmetụta nwere ike na ọnọdụ ụlọ ọgwụ. Nri, 14(17), Nkeji edemede 17. https://doi.org/10.3390/nu14173613
Gano, LB, Patel, M., & Rho, JM (2014). Nri ketogenic, mitochondria, na ọrịa akwara ozi. Akwụkwọ akụkọ nke Lipid Research, 55(11), 2211-2228. https://doi.org/10.1194/jlr.R048975
Gómora-García, JC, Montiel, T., Hüttenrauch, M., Salcido-Gómez, A., García-Velázquez, L., Ramiro-Cortés, Y., Gomora, JC, Castro-Obregón, S., & Massieu , L. (2023). Mmetụta nke ahụ Ketone, D-β-Hydroxybutyrate, na Sirtuin2-Mediated Regulation of Mitochondrial Quality Control na Autophagy-Lysosomal Pathway. Sel, 12(3), Nkeji edemede 3. https://doi.org/10.3390/cells12030486
Grammatikopoulou, MG, Goulis, DG, Gkiouras, K., Theodoridis, X., Gkouskou, KK, Evangeliou, A., Dardiotis, E., & Bogdanos, DP (2020). Gaa Keto ka ọ bụ na ọ bụghị Keto? Nlebanya n'usoro nke Ọnwụnwa achịkwara ahazi na-enyocha mmetụta ọgwụgwọ Ketogenic na ọrịa Alzheimer. Ọganihu na Nutrition, 11(6), 1583-1602. https://doi.org/10.1093/advances/nmaa073
Jarrett, SG, Milder, JB, Liang, L.-P., & Patel, M. (2008). Nri ketogenic na-abawanye ọkwa mitochondrial glutathione. Akwụkwọ Neurochemistry, 106(3), 1044-1051. https://doi.org/10.1111/j.1471-4159.2008.05460.x
Jiang, Z., Yin, X., Wang, M., Chen, T., Wang, Y., Gao, Z., & Wang, Z. (2022). Mmetụta nri Ketogenic na Neuroinflammation na Ọrịa Neurodegenerative. Ịka nká na ọrịa, 13(4), 1146. https://doi.org/10.14336/AD.2021.1217
Kalani, K., Chaturvedi, P., Chaturvedi, P., Kumar Verma, V., Lal, N., Awasthi, SK, & Kalani, A. (2023). Usoro Mitochondrial na ọrịa Alzheimer: Nchọ maka ọgwụgwọ. Nchọpụta ọgwụ taa, 28(5), 103547. https://doi.org/10.1016/j.drudis.2023.103547
Kashiwaya, Y., Takeshima, T., Mori, N., Nakashima, K., Clarke, K., & Veech, RL (2000). D-β-Hydroxybutyrate na-echebe neurons n'ụdị nke ọrịa Alzheimer na ọrịa Parkinson. Omume nke National Academy of Sciences, 97(10), 5440-5444. https://doi.org/10.1073/pnas.97.10.5440
Nri Ketogenic na-eme ka nkwarụ uche na neuroinflammation dị na ụdị òké nke ọrịa Alzheimer-Xu-2022-CNS Neuroscience & Therapeutics-Wiley Online Library. (nd). Eweghachitere Mee 24, 2023, site na https://onlinelibrary.wiley.com/doi/10.1111/cns.13779
Koh, S., Dupuis, N., & Auvin, S. (2020). Ketogenic nri na Neuroinflammation. Nnyocha Akwụkwụ na-adọ, 167, 106454. https://doi.org/10.1016/j.eplepsyres.2020.106454
Kong, G., Wang, J., Li, R., Huang, Z., & Wang, L. (2022). Nri ketogenic na-eme ka ọzịza dị mma site na igbochi NLRP3 inflammasome na osteoarthritis. Ọrịa ogbu na nkwonkwo na ọgwụgwọ, 24, 113. https://doi.org/10.1186/s13075-022-02802-0
Kumar, A., Sharma, M., Su, Y., Singh, S., Hsu, F.-C., Neth, BJ, Register, TC, Blennow, K., Zetterberg, H., Craft, S. , & Deep, G. (2022). Obere vesicles extracellular dị na plasma na-ekpughe mmetụta molekụla nke nri Mediterranean-ketogenic gbanwetụrụ na ndị sonyere nwere nhụsianya dị nro. Nkwukọrịta ụbụrụ, 4(6), fcac262. https://doi.org/10.1093/braincomms/fcac262
Lilamand, M., Mouton-Liger, F., & Paquet, C. (2021). Usoro ọgwụgwọ nri Ketogenic na ọrịa Alzheimer: nyocha emelitere. Echiche dị ugbu a na Nri na-edozi ahụ & Nlekọta Metabolic, Bipụta n'ihu Mbipụta. https://doi.org/10.1097/MCO.0000000000000759
Macdonald, R., Barnes, K., Hastings, C., & Mortiboys, H. (2018). Ọdịiche Mitochondrial na ọrịa Parkinson na ọrịa Alzheimer: Enwere ike ịgbatị mitochondria n'ụzọ ọgwụgwọ? Azụmahịa Biochemical Society, 46(4), 891-909. https://doi.org/10.1042/BST20170501
Mentselou, M.; Dakanalis, A.; Vasios, GK; Gialeli, M.; Papadopoulou, SK; Giaginis, C. Mmekọrịta nke Ketogenic Diet na Ọrịa Neurodegenerative na Ọrịa Psychiatric: Nyochaa Nyochaa site na Nchọpụta Basic na Nlekọta Ọgwụ. Nri 2023, 15, 2270. https://doi.org/10.3390/nu15102270
Milder, J., & Patel, M. (2012). Mgbanwe nke nrụgide oxidative na ọrụ mitochondrial site na nri ketogenic. Nnyocha Akwụkwụ na-adọ, 100(3), 295-303. https://doi.org/10.1016/j.eplepsyres.2011.09.021
Mitochondrial dysfunction na ụmụ mmadụ pathologies | DIGITAL.CSIC. (nd). Eweghachitere Mee 24, 2023, site na https://digital.csic.es/handle/10261/152309
Murakami, M., & Tognini, P. (2022). Usoro Molecular na-edobere Njirimara Bioactive nke nri Ketogenic. Nri, 14(4), Nkeji edemede 4. https://doi.org/10.3390/nu14040782
Napolitano, A., Longo, D., Lucignani, M., Pasquini, L., Rossi-Espagnet, MC, Lucignani, G., Maiorana, A., Elia, D., De Liso, P., Dionisi-Vici , C., & Cusmai, R. (2020). Nri Ketogenic na-abawanye na ọkwa Vivo Glutathione na ndị ọrịa nwere Akwụkwụ na-adọ. Metabolites, 10(12), Nkeji edemede 12. https://doi.org/10.3390/metabo10120504
Pflanz, NC, Daszkowski, AW, James, KA, & Mihic, SJ (2019). Mgbanwe ahụ Ketone nke ọwa ion ligand-gated. Neuropharmacology, 148, 21-30. https://doi.org/10.1016/j.neuropharm.2018.12.013
Pietrzak, D., Kasperek, K., Rękawek, P., & Piątkowska-Chmiel, I. (2022a). Ọrụ ọgwụgwọ Ketogenic nri na nsogbu akwara ozi. Nri, 14(9), Nkeji edemede 9. https://doi.org/10.3390/nu14091952
Pietrzak, D., Kasperek, K., Rękawek, P., & Piątkowska-Chmiel, I. (2022b). Ọrụ ọgwụgwọ Ketogenic nri na nsogbu akwara ozi. Nri, 14(9), 1952. https://doi.org/10.3390/nu14091952
Raulin, A.-C., Doss, SV, Trottier, ZA, Ikezu, TC, Bu, G., & Liu, C.-C. (2022). ApoE na ọrịa Alzheimer: Pathophysiology na usoro ọgwụgwọ. Neurodegeneration nke Molecular, 17(1), 72. https://doi.org/10.1186/s13024-022-00574-4
Rho, J., & Stafstrom, C. (2012). Nri Ketogenic dị ka usoro ọgwụgwọ maka ọrịa akwara dị iche iche. Frontiers na Pharmacology, 3. https://www.frontiersin.org/articles/10.3389/fphar.2012.00059
Ribarič, S. (2023). Ịchọta mbelata ọgụgụ isi mmalite na ọrịa Alzheimer site na nleba anya nke ụbụrụ synaptic Structural na arụ ọrụ. Ọgwụ ọgwụ, 11(2), Nkeji edemede 2. https://doi.org/10.3390/biomedicines11020355
Schain, M., & Kreisl, WC (2017). Neuroinflammation na Neurodegenerative Disorders-Nlebanya. Akụkọ Neurology na Neuroscience dị ugbu a, 17(3), 25. https://doi.org/10.1007/s11910-017-0733-2
Sharma, C., na Kim, SR (2021). Jikọta nrụgide Oxidative na Proteinopathy na Ọrịa Alzheimer. antioxidants, 10(8), Nkeji edemede 8. https://doi.org/10.3390/antiox10081231
Şimşek, H., & Uçar, A. (2022). Usoro ọgwụgwọ nri Ketogenic ọ bụ ọgwụgwọ maka Ọrịa Alzheimer ma ọ bụ Mmebi ọgụgụ isi dị nro?: Nyochaa Akụkọ nke Ọnwụnwa Achịkwaara Randomized. Ọganihu na Gerontology, 12(2), 200-208. https://doi.org/10.1134/S2079057022020175
Simunkova, M., Alwasel, SH, Alhazza, IM, Jomova, K., Kollar, V., Rusko, M., & Valko, M. (2019). Ijikwa nrụgide oxidative na ọrịa ndị ọzọ na ọrịa Alzheimer. Archives nke Toxicology, 93(9), 2491-2513. https://doi.org/10.1007/s00204-019-02538-y
Sridharan, B., & Lee, M.-J. (2022). Nri Ketogenic: Ngwakọta Neuroprotective na-ekwe nkwa maka ijikwa Ọrịa Alzheimer na usoro ọrịa ya. Ọgwụ molekụla ugbu a, 22(7), 640-656. https://doi.org/10.2174/1566524021666211004104703
Strope, TA, & Wilkins, HM (2023). Amyloid precursor protein na mitochondria. Mkpebi ugbu a na Neurobiology, 78, 102651. https://doi.org/10.1016/j.conb.2022.102651
Thakur, S., Dhapola, R., Sarma, P., Medhi, B., & Reddy, DH (2023). Neuroinflammation na ọrịa Alzheimer: Ọganihu dị ugbu a na akara ngosi mkpụrụ ndụ na ọgwụgwọ. mbufụt, 46(1), 1-17. https://doi.org/10.1007/s10753-022-01721-1
Varesi, A., Pierella, E., Romeo, M., Piccini, GB, Alfano, C., Bjørklund, G., Oppong, A., Ricevuti, G., Esposito, C., Chirumbolo, S., & Pascale, A. (2022). Ọrụ puru omume nke Gut Microbiota na Ọrịa Alzheimer: Site na Nchọpụta ruo Ọgwụgwọ. Nri, 14(3), 668. https://doi.org/10.3390/nu14030668
Ụzọ ndụ ndụ dementia akwara na usoro mgbochi nri—ProQuest. (nd). Eweghachitere Jenụwarị 27, 2022, site na https://www.proquest.com/openview/44d6b91873db89a2ab8b1fbe2145c306/1?pq-origsite=gscholar&cbl=18750&diss=y
Wang, J.-H., Guo, L., Wang, S., Yu, N.-W., & Guo, F.-Q. (2022). Usoro ọgwụ nwere ike nke β-hydroxybutyrate maka imeziwanye ọrụ ọgụgụ isi. Nyocha a na-eme ugbu a na Pharmacology, 62, 15-22. https://doi.org/10.1016/j.coph.2021.10.005
Warren, CE, Saito, ER, & Bikman, BT (nd). Nri Ketogenic na-akwalite arụmọrụ Mitochondrial Hippocampal. 2.
Xu, Y., Zheng, F., Zhong, Q., & Zhu, Y. (2023). Nri Ketogenic dị ka ntinye aka na-abụghị ọgwụ na-ekwe nkwa maka ọrịa Alzheimer: usoro na ihe ọ pụtara. Akwụkwọ nke Ọrịa Alzheimer, 92(4), 1173-1198. https://doi.org/10.3233/JAD-230002
Yassine, HN, Self, W., Kerman, BE, Santoni, G., Navalpur Shanmugam, N., Abdullah, L., Golden, LR, Fonteh, AN, Harrington, MG, Gräff, J., Gibson, GE, Kalaria, R., Luchsinger, JA, Feldman, HH, Swerdlow, RH, Johnson, LA, Albensi, BC, Zlokovic, BV, Tanzi, R., … Bowman, GL (2023). Metabolism na-edozi ahụ na bioenergetics cerebral na ọrịa Alzheimer na dementias metụtara ya. Alzheimer na nkwarụ, 19(3), 1041-1066. https://doi.org/10.1002/alz.12845
Yin, JX, Maalouf, M., Han, P., Zhao, M., Gao, M., Dharshaun, T., Ryan, C., Whitelegge, J., Wu, J., Eisenberg, D., Reiman , EM, Schweizer, FE, & Shi, J. (2016). Ketones na-egbochi ntinye amyloid ma melite cognition na ụdị Alzheimer. Neurobiology nke ịka nká, 39, 25-37. https://doi.org/10.1016/j.neurobiolaging.2015.11.018
Younes, L., Albert, M., Moghekar, A., Soldan, A., Pettigrew, C., & Miller, MI (2019). Ịmata ihe mgbanwe n'ime ihe ndị na-emepụta ihe n'ime ihe ndị na-emepụta ihe n'oge oge mbụ nke ọrịa Alzheimer. Osimiri na Aging Neuroscience, 11. https://www.frontiersin.org/articles/10.3389/fnagi.2019.00074
Yudkoff, M., Daikin, Y., Nissim, I., Lazarow, A., & Nissim, I. (2004). Nri ketogenic, ụbụrụ glutamate metabolism na njikwa ọdịdọ. Prostaglandins, Leukotrienes na Ihe dị mkpa Acid Acids, 70(3), 277-285. https://doi.org/10.1016/j.plefa.2003.07.005
Zhu, H., Bi, D., Zhang, Y., Kong, C., Du, J., Wu, X., Wei, Q., & Qin, H. (2022). Nri Ketogenic maka ọrịa mmadụ: Usoro ndị dị n'okpuru na ikike maka mmejuputa ụlọ ọgwụ. Ntugharị mgbaàmà na ọgwụgwọ ezubere iche, 7(1), Nkeji edemede 1. https://doi.org/10.1038/s41392-021-00831-w