Okwu Mmalite

Anọ m n'azụ na-ede akụkọ a. N'ikwu eziokwu, ahapụla m ide banyere iji nri ketogenic na nsogbu iri nri kpamkpam. Achọghị m ime ihe m chere na ọ ga-abụ azụ azụ sitere na mpaghara akparamaagwa ụlọ ọgwụ, nke nwere nkwenye siri ike na ụdị mmachi ọ bụla na nhọrọ nri ga-eduga n'ịbawanye mgbaàmà ma ọ bụ nwee ike ịmepụta nri. nsogbu naanị ya. 

Ma mgbe ahụ, ọ bịara m na ikekwe ndị mmadụ ga-eche na n'ihi na ha ahụghị nsogbu iri nri gụnyere na saịtị a, a gaghị ewere nri ketogenic dị ka nhọrọ ọgwụgwọ. Ma ọ bụ nke ahụ, n'ụzọ ụfọdụ, enweghi ihe akaebe zuru oke iji kwado ojiji ya.

Ma nke ahụ abụghị nnọọ otú ahụ ma ọlị.

Ya mere, n'isiokwu a, m ga-eme ka ndị na-agụ akwụkwọ ọ bụla nwere ike ịbịarute echiche ahụ n'amaghị ama. Mana ihe m na-agaghị eme bụ ịbanye na nkọwapụta nke nsogbu iri nri (BED) ma ọ bụ nye gị ụyọkọ ọnụ ọgụgụ gbasara oke ya. Enwere ọtụtụ posts blọgụ na-enye ọrụ ahụ. M ga-eche na ọ bụrụ na ịchọọ ma ọ bụ hụta akụkọ a, gị ma ọ bụ onye ị hụrụ n'anya achọpụtalarị ma ọ bụ chọpụta na ọ nwere ụdị nsogbu iri nri a. Na na ị nọ ebe a maka ikwu okwu ozugbo banyere ka nri ketogenic nwere ike isi rụọ ọrụ na mgbake yana, ọ bụrụ otu a, otu ọ nwere ike isi gbanwee ụfọdụ usoro ọrịa na-akpata ọrịa anyị na-ahụ na nsogbu a.

Ka ọ na-erule njedebe nke isiokwu a, ị ga-aghọta ihe kpatara na ọ bụghị naanị na a ga-ewere nri ketogenic dị ka ọgwụgwọ kwesịrị ekwesị maka nsogbu iri nri nke Binge (BED) mana ekwesịrị ịnye ya dịka akụkụ nke ọkọlọtọ nlekọta. A na m arịọ mgbaghara ma ọ bụrụ na nkwupụta ahụ enweghị uche ma tinye ụkpụrụ gị ugbu a gbasara otu ihe ndị a si arụ ọrụ n'ihe egwu.

Mana n'ezie, ọ bụ naanị sayensị.

Sayensị N'azụ BED na nri Ketogenic

Ụbụrụ Hypometabolism na BED

Neurons bụ sel metabolic na arụ ọrụ na-achọ ike na-aga n'ihu. Na steeti hypometabolism ụbụrụ, arụmọrụ nke nnabata glucose na ojiji nke neurons na-emebi, na-eduga na ụkọ ike. Ụbụrụ hypometabolism bụ ọnọdụ nke mbelata ọrụ metabolic na ụbụrụ, na ọtụtụ nsogbu na-achọpụta na nwere nke a dị ka ihe na-akpata pathological usoro.

Olee otú anyị si mara nke a? N'ihi na enwere ike ịchọpụta mbelata nke metabolism site na iji usoro onyonyo ahụike dị ka nyocha positron emission tomography (PET), nke na-egosipụta akụkụ ụbụrụ na-adịghị arụ ọrụ nke glucose. Ọrụ mbelata nke a na-ahụ na-agụnyekarị obere nnabata glucose na itinye ya n'ọrụ, nke dị oke mkpa maka ọrụ ụbụrụ. Enwere ike ịhụ ya n'agbanyeghị oke glucose ị na-enweta site na nri gị. Igwe a gbajiri agbaji. Ọ dị ka inwe ụgbọ ala na-agaghị ebido. Ọ baghị uru mmanụ ụgbọala ị na-agbanye n'ime ya, injin agaghị atụgharị wee mepụta ume. Ma ọ bụ ọ bụrụ na ị nwere ihu ọma ma ọ na-eme ya, ọ gaghị aga n'ihu na-agba ọsọ mgbe niile. Ọzọ, ọ baghị uru ole gas (glucose) dị na tank. Igwe (igwe) anaghị arụ ọrụ.

Ịghọta na ịchọpụta ụbụrụ hypometabolism bụ ihe na-elekwasị anya n'ọrịa dị iche iche nke neurodegenerative. Ma ọ naghị enweta nlebara anya zuru oke dị ka onye na-akpata ọrịa pathology na ọrịa uche. Mana enweghị nlebara anya anyị na ya na ndị mmadụ na-enwe mgbaàmà ahụike uche apụtaghị na ọ dịghị mkpa ma ọ bụ na ọ dịghị.

Yabụ, ọ ga-abụ na ọ gaghị eju gị anya mgbe m gwara gị na ndị nyocha na-ahụ mpaghara hypometabolism na ndị nwere nsogbu iri nri (BED).

A na-akọ hypoactivity na sekit frontostriatal na ọmụmụ fMRI anọ nke ndị ọrịa BN na ọnọdụ ọrịa siri ike.

Donnelly, B., Touyz, S., Hay, P., Burton, A., Russell, J., & Caterson, I. (2018). Neuroimaging na bulimia nervosa na nsogbu iri nri: nyocha nhazi. Akwụkwọ akụkọ nke nsogbu iri nri, 6(1), 1-24. https://doi.org/10.1186/s40337-018-0187-1

Ugbu a, achọrọ m ịkọrọ gị, n'ihi nghọta, na ihe ka ọtụtụ n'ime nchọpụta neuroimaging na-eleba anya na mpaghara nke obere ọrụ ma ọ bụ hypometabolism na-ele Bulimia Nervosa (BN) ma ọ bụghị na Binge Eating Disorders (BED) kpọmkwem. Na nyocha na nso nso a nke neuroimaging ọmụmụ, ha chọpụtara na ọ bụ naanị atọ n'ime ihe ọmụmụ iri atọ na abụọ ahụ ha nyochara tụnyere BN na BED.

Ma ọ bụ ezie na m maara na m kwuru na agaghị m abanye n'ime nchọpụta nchọpụta nke Binge Eating Disorder (BED), Achọghị m ka ị nweta echiche na n'ihi na a na-arụ ọrụ ahụ na ndị ọrịa Bulimia, na ọ dịghị mkpa. Wepụta oge iji lelee myirịta na-egbuke egbuke dị n'etiti ha abụọ, dị ka akọwapụtara na ya Akwụkwọ ntuziaka nchọpụta nchọpụta na ọnụ ọgụgụ (DSM-V).

Nhazi	Bulimia Nervosa (BN)	Nsogbu iribiga ihe ókè (BED)
Ihe omume iri oké nri	ugbu	ugbu
Omume nkwụghachi ụgwọ	Dị ugbu a (dịka ọmụmaatụ, vomiting na-ebute onwe ya, iji ọgwụ laxative eme ihe n'ụzọ na-ezighị ezi)	Adịghị
Ugboro nke omume	Opekempe otu ugboro n'izu maka ọnwa atọ	Opekempe otu ugboro n'izu maka ọnwa atọ
Nyocha onwe onye	Ụdị ahụ na ịdị arọ na-emetụta ya nke ọma	Ọ bụghị otu njiri mara nyocha
Nsogbu	Ihe mgbakasị ahụ akara gbasara iribiga oke ókè	Ọtụtụ mgbe metụtara oke iri nri n'onwe ya
Nleba anya nke nyocha	Iri oke nri na-esote omume nkwụghachi ụgwọ	Iri oke ibu na-enweghị omume akwụ ụgwọ
Mmetụta uche	Ọtụtụ mgbe na-emetụta ma iribiga oke ókè yana omume akwụ ụgwọ	Ọtụtụ mgbe metụtara oke iri nri n'onwe ya

Ihe na-ebute oke maka nyocha abụọ a.

A na-eme ụfọdụ ọmụmụ ihe onyonyo n'oge a na-arụ ọrụ, iji hụ mpaghara ụbụrụ na-arụ ọrụ ma ọ bụ na-adịghị arụ ọrụ ozugbo. N'oge ọrụ ọgụgụ isi ma ọ bụ arụ ọrụ, mpaghara hypometabolic nwere ike ọ gaghị egosipụta mmụba a na-atụ anya na ọrụ n'ihi na ọ na-ebelata ikike metabolic (ikike ime ike). Enweghị nzaghachi a ma ọ bụ mbelata ịgbalite nwere ike na-abụkarị nsonaazụ nke hypometabolism dị n'okpuru.

N'oge na-adịbeghị anya, anyị hụrụ ọdịiche ịgbalite ụbụrụ n'etiti ndị buru oke ibu nwere ma na-enweghị BED n'oge ọrụ njikwa ọgụgụ isi, yana ndị otu BED na-egosipụta ike dị ntakịrị na IFG, vmPFC, na insula (38).

Donnelly, B., Touyz, S., Hay, P., Burton, A., Russell, J., & Caterson, I. (2018). Neuroimaging na bulimia nervosa na nsogbu iri nri: nyocha nhazi. Akwụkwọ akụkọ nke nsogbu iri nri, 6(1), 1-24. https://doi.org/10.1186/s40337-018-0187-1

Ọmụmụ Neuroimaging nke lekwasịrị anya na nsogbu iri nri (BED) gosipụtara ọdịiche dị ukwuu na ọrụ ụbụrụ, na-ekpughe na ndị buru oke ibu nwere BED na-egosipụta ọrụ belatara na Ventromedial Prefrontal Cortex (vmPFC) mgbe ekpughere ya na akara nri ma e jiri ya tụnyere ndị na-enweghị BED. VmPFC dị mkpa maka ime mkpebi na nzaghachi mmetụta uche, na-atụ aro na BED na-emetụta ka ndị mmadụ si ahazi mkpali metụtara nri.

Nnyocha achọpụtala na n'oge ọrụ nchịkwa ọgụgụ isi, ndị buru oke ibu nwere BED gosipụtara mbelata ọrụ na Inferior Frontal Gyrus (IFG) na Insula. A na-echepụta ọrụ a belatara na IFG na Insula n'etiti ndị BED iji rụtụ aka n'iche dị iche iche na ikike ha nwere ịchịkwa ọgụgụ isi yana otu ha si aghọta steeti dị n'ime metụtara omume iri nri.

Usoro akwara ndị a pụrụ iche dị na BED na-egosi mbelata ọrụ, ọkachasị na mpaghara ụbụrụ jikọtara ya na ime mkpebi, nhazi mmetụta uche, na njikwa ọgụgụ isi n'ihe gbasara iri nri.

Ọ bụ na ntinye aka nke na-eleba anya n'ụzọ dị irè mbelata mbelata nke hypometabolism na-akpata na ndị mmadụ a agaghị abụ ọgwụgwọ bara uru?

Abịara m ebe a ịgwa gị otu dị.

Nri ketogenic bụ ọgwụgwọ amaara maka ọnọdụ nwere akụkụ ụbụrụ hypometabolism. Ha na-enye mmanụ ọzọ n'ụdị ketones nke ụbụrụ na-agụ maka ume na-ebuli ngwa ngwa ma na-agafe igwe glucose gbajiri agbaji na-etinye aka na steeti hypometabolic. Ma anyị maara nke a ruo ogologo oge.

Ụbụrụ nwere ike ma na-adabere, opekata mpe n'akụkụ ya, na ihe ndị ọzọ, ọkachasị ahụ ketone.

Sokoloff, LOUIS (1973). Metabolism nke ahụ ketone site na ụbụrụ. Nyochaa ọgwụ kwa afọ, 24 (1), 271-280. https://doi.org/10.1146/annurev.me.24.020173.001415

Ozugbo n'ime neuron, ahụ ketone na-enweta mgbanwe mgbanwe biochemical nke na-eme ka a na-eji ya eme ihe site na eriri njem elektrọn iji mepụta ATP (ike). Ọbụghị naanị na ha na-arụ ọrụ dị ka isi iyi mmanụ, mana ha bụkwa isi iyi mmanụ ọkụ, nke nwere ike inyekwu ATP (ike) karịa ka a na-ahụ ya na ojiji glucose, na-eme ka ọ rụọ ọrụ nke ọma. Mmepụta ATP (ike) a sitere na metabolism ketone nwere ike inye aka igbochi hypometabolism nke njiri glucose na-adịghị mma kpatara.

Achọghị m ka ị chee na n'ihi na ọ nweghị Randomized Controlled Trials (RCT) ma (n'oge nke isiokwu a) na-eji ketogenic diets kpọmkwem maka Binge Eating Disorder (BED), anyị amaghị ma ghọta ụzọ nke. nri ketogenic nwere ike ịgwọ usoro ọrịa na-adịghị ala ala anyị na-ahụ ịnya ụgbọ ala ma ọ bụ na-akwado mgbaàmà.

Ahụ Ketone (KBs) bụ isi iyi ike maka ụbụrụ.

Morris, AAM (2005). Cerebral ketone metabolism. Akwụkwọ akụkọ nke ọrịa metabolic ketara eketa, 28 (2), 109-121.  https://doi.org/10.1007/s10545-005-5518-0

Achọrọ m ịkọwapụta na iji nwee njide onwe onye, ​​​​ịkwesịrị ịnwe lobe ihu na-arụ ọrụ iji chụpụ mgbochi omume. Akọrọla m gị na akwụkwọ nyocha dị nke na-egosi na ndị mmadụ na-arịa ọrịa binge nwere ebe dị n'ihu ihu ha na-adịghị arụ ọrụ nke ọma, ikekwe n'ihi usoro hypometabolic.

Ka anyị na-abanye na mmetụta nke nri ketogenic na neurotransmitters na site na nke ọzọ nke isiokwu a, achọrọ m ka ị buru nke ahụ n'uche.

Mana nke ahụ bụ naanị otu ụzọ nri ketogenic nwere ike isi nyere aka gbanwee ihe anyị na-ahụ na-eme na ụbụrụ ndị mmadụ nwere nsogbu iri nri (BED). Ka anyị gaa n'ihu hụ ụzọ ndị ọzọ ọ nwere ike isi bụrụ ọgwụgwọ.

Agbaghara Neurotransmitter na BED

Enwere ọtụtụ nkwụsịtụ na ọrụ neurotransmitter a na-ahụ na ndị mmadụ na-ezute njirisi maka ọrịa iri nri na-eri nri na plethora nke ọgwụ mgbaka na-eji iji gbanwee ha maka mbelata mgbaàmà.

Mana kedu ihe dị iche iche na ọrụ neurotransmitter anyị na-ahụ na nsogbu iri nri nke Binge (BED) nke dabara na mmetụta ndị a na-ahụ na nri ketogenic? Mgbe anyị na-ekwu maka ọrụ neurotransmitter, anyị na-ekwukarị maka ezughi oke ma ọ bụ nke ukwuu, mana n'ezie, anwansi ahụ dị gburugburu ka ndị neurotransmitters si arụ ọrụ.

Glutamate/GABA ọrụ

Ọrụ Glutamate dị mkpa na nsogbu iri nri (BED). Nke mere na ndị na-eme nchọpụta na-enyocha ndị na-anabata glutamate dị iche iche dị ka ndị nwere ike ịchọta ọgwụ maka ọgwụgwọ. Ndị na-anabata Glutamate na-ekere òkè n'otú ndị mmadụ si enweta mmetụta nke ụgwọ ọrụ na ịchịkwa àgwà iri nri. A na-eche na ọgwụ emepụtara iji gbanwee ndị na-anabata ya nwere ike inye aka jikwaa iribiga ihe ókè na iribiga nri ókè site n'ịgbanwe nzaghachi ụbụrụ na ụgwọ ọrụ metụtara nri.

… Mgbanwe na-adịghị mma nke mGluR5 na-ebelatakwa iribiga ihe ókè, ụdị nsogbu iri ihe na-adịkarị. Ngụkọta nsonaazụ anyị rụtụrụ aka na mGluR5 dị ka ebumnuche enwere ike ịgwọ oke ibu yana nsogbu ndị metụtara ya.

Oliveira, TP, Gonçalves, BD, Oliveira, BS, De Oliveira, ACP, Reis, HJ, Ferreira, CN, … & Vieira, LB (2021). Mgbanwe na-adịghị mma nke metabotropic glutamate Receptor ụdị 5 dị ka atụmatụ ọgwụgwọ nwere ike na oke ibu na omume iri nri. N'ihu Neuroscience, 15, 631311. https://doi.org/10.3389/fnins.2021.631311

Nchọpụta ọzọ dị ịrịba ama bụ na mgbe mgbe, mgbe mmepe nke nsogbu nrụgide post-traumatic (PTSD), nsogbu iri nri dị iche iche, gụnyere nsogbu iribiga nri ókè, nwere ike ịmalite. Ụfọdụ nnyocha lekwasịrị anya na mgbanwe mgbanwe na glutamatergic neurotransmission achọtara na ọnọdụ ndị a. A na-eche na oke mkpali nke glutamate na-eduga na excitotoxicity, nke na-ebute oke hypothalamic-pituitary-adrenal axis, na trauma ma ọ bụ oke nrụgide na-akpata mgbanwe na ọrụ glutamate nwere ike ịkpalite mmalite nke PTSD na nsogbu iri nri na-esote.

Ịgbanwe ọrụ glutamatergic nwere ike bụrụ ụzọ dị mkpa n'ịgwọ ndị nwere nsogbu ndị a. 

Nyochaa ugbu a na-atụ aro na ọrụ glutamate gbanwere site na trauma ma ọ bụ oke nrụgide nwere ike ịkwado PTSD na mmalite nsogbu iri nri na-esote, na mgbanwe glutamatergic nwere ike ịbụ ọgwụgwọ bụ isi ...

Murray, SL, & Holton, KF (2021). Nsogbu nrụgide post-traumatic nwere ike ịtọ usoro neurobiological maka nsogbu iri nri: ilekwasị anya na dysfunction glutamatergic. Agụụ, 167, 105599. https://doi.org/10.1016/j.appet.2021.105599

Ọ bụ ezie na a na-ewere glutamate dị ka neurotransmitter na-akpali akpali, y-amino-butyric acid (GABA) bụ ihe mgbochi. A na-eji ọgwụ na-agbanwe GABA maka ọrịa akwụkwụ na ọgwụgwọ mmanya na nsogbu iji ihe eme ihe. Mana ejirila otu ọgwụ ndị a na ọgwụgwọ ọrịa iri nri nke Binge (BED).

Iji mee ka ọ dị mfe ma kọwaa ya n'ozuzu, ọ dịghị ka ọ dị "zuru ezu" GABA, ma ọ bụ ọrụ GABA iji gbochie mmetụta na-akpali akpali nke a na-ahụ na mmepụta glutamate dị elu nke akpọtụrụla. A na-ahụ GABA ka ọ na-etinye mmetụta na ụgwọ ọrụ na omume inye nri metụtara iribiga ihe ókè. N'ụzọ bụ isi, iji mee ka obi dajụọ ya.

N'ezie, ịgbalite VTA [ventral tegmental area] GABAergic neurons na-egbochi neurons dopaminergic ma na-egbochi ngwa ngwa sucrose ngwọta n'ime anụmanụ ndị amachibidoro nri.

Yang, B. (2021). Mgbe ịkwụsị iri nri: breeki inyeaka na oriri nri sitere na nucleus accumbens. Akwụkwọ Neuroscience, 41(9), 1847-1849.  https://doi.org/10.1523/JNEUROSCI.1666-20.2020

Dysfunction na neurotransmitter GABA na-emetụta ya nke ọma na ọgwụ ndị a na-eji eme ihe mgbe a bịara na nsogbu iri nri (BED), ndị nchọpụta na-ahụ ọrụ GABA na-emetụta, n'agbanyeghị na ọ bụghị ike dị ka a na-ahụ ya na dopamine.

O nwere ike iju gị anya ịmata na a na-eji ọgwụ ADHD eme ihe na ọnụ ọgụgụ a, n'otu akụkụ n'ihi mmetụta nke ọgwụ ndị ahụ na dopamine.

Ọgwụ ndị na-eme ka noradrenergic na dopaminergic neurotransmission na / ma ọ bụ dị irè na ADHD bụ ebe kachasị mma maka ọgwụgwọ ọhụrụ maka BED

Feng, B., Harms, J., Chen, E., Gao, P., Xu, P., & He, Y. (2023). Ihe nchoputa ugbu a na ihe ga-eme n'ọdịnihu nke nsogbu iri nri. Akwụkwọ akụkọ mba ụwa nke nyocha gburugburu ebe obibi na ahụike ọha, 20 (14), 6325. https://doi.org/10.3390/ijerph20146325

Dopamine na Serotonin

N'ọnọdụ ndị e ji iri oke nri mara, dị ka a na-ahụ na nsogbu iri nri nke Binge (BED), enwere ọgba aghara na netwọkụ ụbụrụ nke dị mkpa maka mkpali, ịchọta ihe ụtọ, ime mkpebi, na njide onwe onye. N'okporo ụzọ mesolimbic, ọgba aghara a gụnyere glutamate na dopamine.

Mgbe a na-enyocha BED n'ìhè nke echiche iri nri na-akpali akpali / nke na-amanye, yana ụkpụrụ ya nke ụbụrụ na-enye ụgwọ ọrụ usoro echiche, dopaminergic neurotransmission yiri ka ọ bụ ụzọ neuropathway na-adọrọ mmasị.

Levitan, MN, Papelbaum, M., Carta, MG, Appolinario, JC, & Nardi, AE (2021). Nsogbu iri nri nke ukwuu: Nnyocha nyocha nke afọ 5 na ọgwụ nnwale. Akwụkwọ akụkọ nyocha ọgwụ, 33-47. https://doi.org/10.2147/JEP.S255376

A na-eji nsogbu iri nri nke ukwuu ma ọ bụ ọnọdụ hyperdopaminergic, yana ọrụ dopamine na-abawanye, ma ọ bụ ọnọdụ hypodopaminergic, nke ọrụ dopamine belatara akara.

D1 na D2 dopamine anabata, nke dị na striatum na prefrontal cortex, na-ahazi ọrụ dị oke mkpa dị ka agụụ nri, ime mkpebi, na ọrụ ndị isi. Mgbanwe na nnweta ha na mmekọrịta ha na-emetụta oke omume iri nri.

Mkpụrụ ndụ ihe nketa polymorphisms, karịsịa na D2, D3, na D4 mkpụrụ ndụ ihe nketa nnabata, na-enye aka na mgbanwe nke onye ọ bụla na ọrụ nnata. Ndịiche mkpụrụ ndụ ihe nketa ndị a nwere ike imetụta ka usoro dopaminergic nke mmadụ si anabata ihe gbasara gburugburu ebe obibi na omume, na-emetụta ike ha na omume iri nri.

Ewezuga mkpụrụ ndụ ihe nketa, ọrụ nnabata dopamine na-emetụta nke ukwuu site na ndụ na ihe gburugburu ebe obibi. Dịka ọmụmaatụ, iri shuga dị elu ma ọ bụ nri nwere oke abụba nwere ike gbanwee nnweta dopamine, dị ka mgbanwe neuroadaptive a na-ahụ na nsogbu iji ihe eme ihe. Na mgbakwunye, neuroplasticity nke ụbụrụ na-enye ndị na-anabata ndị a ohere ime mgbanwe na nzaghachi omume iri nri na-adịghị ala ala, nwere ike ibelata nzaghachi dopamine ka oge na-aga.

Dopamine neurotransmitter na-etinye aka na agụụ nri, ime mkpebi, ịrụ ọrụ onye isi, na àgwà enweghị mmasị; ihe niile na-enye aka na mmepe na mmezi nke iri nri.

Blanco-Gandia, MC, Montagud-Romero, S., & Rodríguez-Arias, M. (2021). Iri oke ibu na ihe riri ahụ psychostimulant. Akwụkwọ akụkọ ụwa nke Psychiatry, 11(9), 517. http://dx.doi.org/10.5498/wjp.v11.i9.517

Nchegbu na ọnọdụ mmetụta uche na-ekerekwa òkè dị ukwuu n'ịgbanwe ọrụ nnata dopamine. Nchegbu na-adịghị ala ala nwere ike gbanwee ụzọ mgbaàmà dopamine, na-emetụta njupụta na uche nke ndị na-anabata ya ma si otú a na-emetụta usoro iri nri.

Ọgwụgwọ ọgwụ maka BED mgbe ụfọdụ na-agụnye ndị na-emechi ihe nchịkwa serotonin (SSRIs), nke na-abawanye oge nke serotonin dị adị na synapse nke neuron. Nke a na-ezube ịbawanye nnweta serotonin maka ojiji na ụbụrụ. N'ime mmepe nke BED, enwere nleba anya nke ụbụrụ serotonin na-adịghị mma, ihe bụ isi na-achịkwa ọnọdụ ọnọdụ na omume iri nri.

N'ime mmepe nke BED na ụmụ mmadụ, a hụla nrịbama ụbụrụ serotonin (5-HT). 

Feng, B., Harms, J., Chen, E., Gao, P., Xu, P., & He, Y. (2023). Ihe nchoputa ugbu a na ihe ga-eme n'ọdịnihu nke nsogbu iri nri. Akwụkwọ akụkọ mba ụwa nke nyocha gburugburu ebe obibi na ahụike ọha, 20 (14), 6325. https://doi.org/10.3390/ijerph20146325

Sistemụ serotonergic, tinyere aka n'ịkwalite akara satiety na nhazi ọnọdụ, na-egosi mperi na BED, ọkachasị n'ime ụmụ nwanyị nwere oke ibu. Nke a na-eduga n'ajụjụ na-akpali akpali: nri ketogenic ọ nwere ike imetụta serotonin na ndị ọzọ neurotransmitters na BED? Nchọpụta na-apụta na-atụ aka na njikọ dị mma. Ọgwụ ndị a na-eji maka nchoputa a gụnyere Tricyclic Antidepressants (TCAs), Serotonin 5-HT2C Receptor Agonists, na Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs).

Yabụ, nri ketogenic ọ ga-enwe mmetụta na ndị a na neurotransmitters ndị ọzọ metụtara n'ịgwọ ọrịa iri nri Binge (BED)?

Ọ dị ka ọ siri ike ịbụ ikpe.

Na ndabere nke ihe akaebe a, ahụ ketone nwere ike ịhazi nzuzo nke neurotransmitters dị ka GABA, glutamate, serotonin, dopamine, na ụbụrụ neurotrophic nke sitere na ụbụrụ na-etinye aka na pathology neurologic.

Chung, JY, Kim, OY, & Song, J. (2022). Ọrụ nke ahụ ketone na dementia na-akpata ọrịa shuga: sirtuins, nguzogide insulin, plastik synapti, arụ ọrụ mitochondrial, na neurotransmitter. Nlebanya nri, 80(4), 774-785. https://doi.org/10.1093/nutrit/nuab118

Nri ketogenic amarala mmetụta na mgbanwe mgbanwe neurotransmitter nke ga-atụ aro na ọ na-enye nsonaazụ ọgwụgwọ maka ndị na-ahụ maka neurotransmitters hụrụ dị ka ihe dị mkpa na okike na mmezi nke omume iri nri.

Ma gịnị banyere usoro ndị ọzọ dị n'okpuru anyị na-ahụ na ha na-etinye aka na nsogbu a? A na-ahụkwa neuroinflammation na nrụgide oxidative na nsogbu a, dị ka ọtụtụ ndị a na-enyocha ma dee banyere ya na blọọgụ a?

Azịza ya bụ ee.

Neuroinflammation na Nchegbu Oxidative na BED

Neuroinflammation nwere ike ime n'ihi ihe dị iche iche. O nwere ike ịbụ n'ihi na neurons na-agbasi mbọ ike maka ike, adịghị ike nke micronutrients na-egbochi ọrụ neuronal nkịtị na nlekọta ụlọ, ma ọ bụ ikpughe na ihe ndị gafere ihe mgbochi ụbụrụ ọbara nke na-ekwesịghị ịdị. Ma ọ bụ, ụbụrụ na-awụsa na ọkwa glucose (sugar) ọ nweghị ike iji n'ihi nguzogide insulin nke ụbụrụ.

Ụbụrụ Leaky na nri ketogenic

Ọ na-emekwa mgbe usoro ahụ ji alụso ọrịa ọgụ na-arụ ọrụ n'ihi nje virus ma ọ bụ nje nje. N'agbanyeghị ihe kpatara ya, usoro ahụ ji alụso ọrịa ọgụ nke ụbụrụ na-arụ ọrụ mgbe nhụjuanya a mere. Na n'ozuzu, nke ahụ dị mma. Ọ na-ahapụ cytokines proinflammatory iji nyere aka mee ka ihe laghachi azụ. Neuroinflammation bụ nzaghachi neuroimmunological nkịtị na-echebe gị. Ma n'ọtụtụ ọnọdụ ahụike uche ndị a tụlere na blọgụ a, neuroinflammation na-aghọ onye na-anya ụgbọ ala na-adịghị ala ala nke mgbaàmà. 

Ya mere ọzọ, ọ bụghị ihe ijuanya na achọpụtara neuroinflammation dị ka usoro na-akpata ọrịa na-akpata nsogbu iri nri, gụnyere ọrịa iri nri (BED). Ọkwa dị elu nke cytokines proinflammatory dị ka Tumor Necrosis Factor Alpha (TNFα), Interleukin 1 Beta (IL1ß), na Interleukin 6 (IL6) bụ ihe na-egosi usoro neuroinflammatory. Cytokines ndị a dị mkpa na usoro mkpali, na ọnụnọ ha dị elu na nsogbu iri nri na-egosi na ha na-ekere òkè nke neuroinflammation na pathology nke ọnọdụ ndị a.

N'ihe gbasara ED, a kọwo ọkwa dị elu nke plasma nke cytokines proinflammatory (TNFα, IL1ß na IL6) yana ndị ọzọ na-eme mkpesa na oxido-nitrosative mediators (COX2, TBARS).

Ruiz-Guerrero, F., Del Barrio, AG, de la Torre-Luque, A., Ayad-Ahmed, W., Beato-Fernandez, L., Montes, FP, … & Díaz-Marsá, M. (2023) . Nchegbu oxidative na ụzọ mkpali na nsogbu iri nri nke ụmụ nwanyị na nsogbu mmadụ nwere oke nwere nhụsianya mmetụta uche dị ka ihe jikọtara ya na mkpali na trauma. Psychoneuroendocrinology, 158, 106383. https://doi.org/10.1016/j.psyneuen.2023.106383

Maka ndị nwere BED na oke oke ibu, ịdị adị nke ọrịa na-adịghị ala ala, nke dị ala na-edekọ nke ọma, na-ejikọta ọkụ na ụdị anụmanụ na ọrụ ụbụrụ nke na-emetụta omume mmetụta uche na ebe nchekwa.

Cytokines pro-inflammatory na-etinye aka na nchịkwa iri nri site n'ime ihe hypothalamus ma na-eche na ọ ga-emetụta nguzozi nke orexigenic (agụụ-akpali akpali) na anorexigenic (na-egbochi agụụ) neurons n'ime hypothalamus, nwere ike imetụta agụụ na nhazi satiety.

Ihe akaebe dị ugbu a na-egosi mmekọrịta nwere ike ime n'etiti ihe nrịbama ọkụ/ọgwụ mgbochi yana omume iri nri metụtara oke ibu.

Meng, Y., & Kautz, A. (2022). Nlebanya ihe akaebe nke njikọ nke ihe nrịbama mgbochi na mkpasu iwe nwere omume iri ihe metụtara oke ibu. Frontiers na Immunology, 13, 902114. https://doi.org/10.3389/fimmu.2022.902114

Mgbe neuroinflammation na-adịghị ala ala, usoro antioxidant nke anụ ahụ nke a na-eji ehichapụ mmebi nke neuroinflammation na-akpata nwere ike ghara ezuru. Nke a bụ mgbe nrụgide oxidative na-eme. Okwu a na-ezo aka n'ụbụrụ enweghị ike ijigide ọkwa mmebi a na-eme. 

Ọ bụrụ na ị ka amachaghị banyere ọdịiche dị n'etiti neuroinflammation na nrụgide oxidative, ị nwere ike ịnụ ụtọ isiokwu a n'okpuru.

Ọ bụrụ na ụbụrụ gị bụ obodo: Ịghọta Nchegbu Oxidative na Neuroinflammation

Site na ike nke nyocha ahụ na-akwado na ma neuroinflammation na nrụgide oxidative dị na ndị mmadụ na-eri nri, yana na Binge Eating Disorder (BED) kpọmkwem, ọ na-eduga na ajụjụ ebumpụta ụwa nke ma nri ketogenic nwere ike inwe mmetụta ọgwụgwọ bara uru na ihe ndị a.

Ka m were isi na-ada ee zaa ajụjụ gị.

βOHB bụ onye na-egbochi histone deacetylases nke na-ebute mmụba nke mkpụrụ ndụ ihe nketa na-etinye aka na nchebe megide nrụgide oxidative ...

Achanta, LB, & Rae, CD (2017). β-Hydroxybutyrate na ụbụrụ: otu molekul, ọtụtụ usoro. Nnyocha neurochemical, 42, 35-49. https://doi.org/10.1007/s11064-016-2099-2

Ngwaahịa fatty acid nke KD na-emekwa ka ihe ntụgharị ederede rụọ ọrụ maka protein na-akwalite neuroprotection site n'ịhazi ngosipụta nke pro-mitochondrial antioxidant na akara mgbochi mkpali.

Nri ketogenic na-emetụta usoro nrụgide oxidative na ụbụrụ, na akụkụ site na ịgbalite ụzọ NRF2. NRF2 (Nuclear Factor Erythroid 2-Related Factor 2) bụ isi ihe ederede nke na-achịkwa nzaghachi cellular na nrụgide oxidative site na ịmalite nsụgharị nke ọtụtụ mkpụrụ ndụ ihe nketa na-ahụ maka nchebe antioxidant na detoxification.

Kedu ihe kpatara o ji dị mkpa, kedu ihe kpatara anyị ga-eji lebara nke a anya maka ahụike ụbụrụ yana dịka usoro ọgwụgwọ na ọrịa dịka Binge Eating Disorder (BED) na ọtụtụ ndị ọzọ?

N'ihi na ọ na-eduga n'ịbawanye mmepụta nke ụmụ irighiri ihe antioxidant dị oke mkpa dị ka glutathione, yana enzymes ndị ọzọ dị mkpa na-etinye aka na-egbochi ikuku oxygen na ụdị nitrogen. Mgbanwe ụmụ irighiri ihe ndị a na-enye aka nke ukwuu na mbelata nrụgide oxidative n'ime ụbụrụ. N'ịkwalite site na nri ketogenic, nzaghachi NRF2-mediated antioxidant nzaghachi bụ ihe na-agbanwe egwuregwu n'ihi na ọ na-enyere aka chebe mkpụrụ ndụ akwara site na mmebi oxidative.

Nri ketogenic na-agbanwekwa PPARgamma (Peroxisome Proliferator-Activated Receptor Gamma). PPARgamma bụ ihe nnabata nuklia dị mkpa nke na-arụ ọrụ dị oke mkpa n'ịchịkwa metabolism lipid, glucose homeostasis, na nguzozi ike. Karịa naanị ịhazi ọrụ metabolic, PPARgamma na-enyere aka ịchịkwa ọtụtụ mkpụrụ ndụ ihe nketa jikọtara ya na nzaghachi mgbochi mkpali na antioxidant. Mgbe ọ na-arụ ọrụ, ọ na-eduga na nsụgharị nke mkpụrụ ndụ ihe nketa na-eme ka metabolism cellular dịkwuo elu, belata mbufụt, ma melite ọrụ mitochondrial. Nke a bụ usoro dị mkpa nke ime ihe na-enye uru ọgwụgwọ.

Mmechi: Ịkekọrịta Nhọrọ dabere na ihe akaebe

Nsogbu iri nri nke binge (BED) bụ ihe ịma aka juru ebe niile, na-emetụta ihe dịka 0.9% nke ndị mmadụ n'oge ndụ ha niile. Ọ bụ nsogbu iri nri na-emekarị, na-esonyere ya na ụbara psychopathology na nsogbu ndị metụtara oke ibu.

Atụmatụ ugbu a adịghị arụ ọrụ nke ọma maka onye ọ bụla. N'agbanyeghị nke ahụ, nri ketogenic na-ekwu kpọmkwem banyere neurobiological na metabolism nke nwere ike inye aka na-ebute nsogbu iri nri (BED). Hypometabolism, neurotransmitter adịghị mma, neuroinflammation, nrụgide oxidative - nri ketogenic egosila ikike ijikwa ndị a, yana ọtụtụ ndị ọzọ.

Dabere na ihe akaebe sayensị gosipụtara… Usoro mmụta mmekọrịta a kwesịrị ijikọ usoro ọgwụgwọ ndụ ahaziri ahazi yana atụmatụ nri ahụike siri ike, PA, na mmemme omume, dịka otu ndị ọkachamara na-ahụ maka multidisciplinary si kwuo

Feng, B., Harms, J., Chen, E., Gao, P., Xu, P., & He, Y. (2023). Ihe nchoputa ugbu a na ihe ga-eme n'ọdịnihu nke nsogbu iri nri. International Journal of Environmental Research na Ahụike Ọha, 20(14), 6325. https://doi.org/10.3390/ijerph20146325

Mgbe nyocha nyocha nke ndị ọgbọ na-akwado maka atụmatụ ọgwụgwọ ndụ ahaziri ahazi nke gụnyere nri, mmega ahụ, na mmemme omume, o doro anya ebe nri ketogenic dabara. Ọ bụghị ihe ọzọ mana nhọrọ dị mkpa, nke ihe akaebe sayensị kwadoro, ka etinyere ya na ọkọlọtọ nlekọta maka BED.

N'iburu n'ọba ụba nke BED na eziokwu na ọgwụgwọ ugbu a anaghị arụ ọrụ maka onye ọ bụla, nri ketogenic na-enye olileanya. Ọ bụ ụzọ kwụ ọtọ, dabere na ihe akaebe nke nwere ike imere ọtụtụ ndị ezigbo mgbanwe. Ndị ọkachamara ahụike na akparamaagwa kwesịrị ịtụle ya nke ọma dị ka akụkụ nke usoro ọgwụgwọ multidisciplinary maka BED.

Ajụjụ m ga-abụ, ọ bụrụ na ndị ahụ bụ ndụmọdụ ọgwụgwọ ndị e depụtara na akwụkwọ, gịnị kpatara na enweghị ike ịgụnye nri ketogenic? Ọ bụrụ na gị ma ọ bụ onye ị hụrụ n'anya na-arịa ọrịa Binge Eating Disorder (BED), echere m na ị nwere ike ịme ikpe maka nke ahụ site na ihe ọmụma ọhụrụ gị sitere na edemede a. Dọkịta gị nwere ike ịgakwuru onye na-ahụ maka nri ma ọ bụ onye na-ahụ maka nri nri, ma ị nwere ike ịrịọ ka a zụọ ha na nri ketogenic ma were ohere nke ọzụzụ ahụ n'ihe ndị ọzọ metụtara ndụ dị mkpa chọpụtara na ọ na-enyere aka na mgbake.

Ma ugbu a ị ghọtara otú nri ketogenic si emetụta ụfọdụ usoro ndu ndị na-akpata nsogbu ahụ, ị ​​​​nwere ike ịnọ ebe ka mma ịme ụdị mkpebi ahụ dị mkpa n'onwe gị. Ọ bụ olileanya m na ị nọ n'ọnọdụ ka mma ịkwado onwe gị na dọkịta gị na ụlọ ọrụ ịnshọransị iji nweta nri nri ketogenic dị ka ọgwụgwọ karịa ka ọ dị mgbe ị malitere.

Ọ bụrụ na ị na-achọ ịgbakwunye onye na-ahụ maka ihe ọmụma ketogenic na otu ọgwụgwọ gị ma ọ bụ otu maka onye ị hụrụ n'anya, m ga-amalite na Health Mental Health Keto Training and Resource Page.

Akụrụngwa ahụike uche maka nri Ketogenic

Nnyocha na usoro ndị dị n'okpuru siri ike. Ma, achọghị m ka ị chee na isiokwu a bụ naanị usoro iwu. Akwụkwọ nyocha dị n'ezie na-eji nri ketogenic dị ka ọgwụgwọ maka nsogbu iri nri (BED). Ọ dịkwa m ụtọ inye gị mmalite nke ihe ha hụrụ n'isiokwu a n'okpuru.

Nlebanya dị nkenke nke nyocha banyere nri ketogenic dị ka ọgwụgwọ maka nsogbu iri nri (BED)

References

Achanta, LB, & Rae, CD (2017). β-Hydroxybutyrate n'ime ụbụrụ: Otu Molecule, ọtụtụ usoro. Nnyocha Neurochemical, 42(1), 35-49. https://doi.org/10.1007/s11064-016-2099-2

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Chung, JY, Kim, OY, & Song, J. (2022). Ọrụ nke ahụ ketone na dementia na-akpata ọrịa shuga: Sirtuins, nguzogide insulin, plasticity synapti, mitochondrial dysfunction, na neurotransmitter. Nutrition Nyocha, 80(4), 774-785. https://doi.org/10.1093/nutrit/nuab118

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