Oge echere ịgụ oge: 19 nkeji

Okwu Mmalite

Ọ bụrụ na ị na-agụ blọọgụ a, ọ nwere ike ịbụ n'ihi na ị na-enyo enyo ma ọ bụ nwee nchoputa nke mmerụ ahụ dị nro (MCI). Ụfọdụ ikpe nke nhụsianya dị nro (MCI) ga-akwụsị na-aga n'ihu ma ghara ịga n'ihu na-arụ ọrụ na-adịghị mma na ọkwa iji zute njirisi maka Dementia.

Mmetụta Mmetụta Na-adịghị Agbanwe

Kedu ihe bụ mmerụ ahụ dị nro (MCI)? Malite ebe a:

Mana imirikiti n'ime nsogbu nhụta dị nro (MCI) ga-etolite ghọọ mgbaka. Ma ọ bụrụgodi na ọganihu neurodegenerative gị kwụsịrị na Mild Cognitive impairment (MCI), mgbaàmà ndị ahụ na-emetụta ndụ gị na ọrụ gị. N'ụzọ dị mwute, ọ dịghị ọgwụgwọ stellar karịsịa maka ụdị nhụta izugbe nke a na-ahụ na nkà mmụta ọgwụ bụ isi, n'ezie, e nwere ọgwụgwọ na nchọpụta magburu onwe ya achọpụtara iji melite arụ ọrụ.

Ya mere, ma ịchọrọ ka ụbụrụ gị laghachi azụ site n'ịghọta mmalite n'ụdị ụbụrụ ụbụrụ na-emegharị ma ọ bụ nke na-adịghị ala ala na / ma ọ bụ mgbaàmà dị nro na-adịghị mma (MCI), ma ọ bụ na ị na-achọ ịkwụsị ọganihu neurodegenerative n'ime Alzheimer ma ọ bụ ụdị dementia ọzọ, nke a. bụ blọọgụ maka gị. Ị nwere ike na-agụ nke a blọọgụ post ọ bụghị n'ihi na ị na-ata ahụhụ site na mgbaàmà nke cognition ọdịda, ma na-eme nnyocha ka esi enyere onye ị hụrụ n'anya aka. Ma ọ bụrụ na nke ahụ bụ ikpe, nke a ka bụ blọọgụ maka gị.

Enwere ike inwe ọtụtụ ihe na-eme ka ọgụgụ isi daa. Ma ekwela ka nke ahụ rigbuo gị. Enwere ebe mbụ ị ga-amalite nke ga-eme ka mgbaàmà dịkwuo mma ma tọọ ntọala maka nyocha na nkwalite ọ bụla ọzọ a ga-eme. Enwere ọtụtụ ihe na-adaba n'ụbụrụ na mgbaama mgbaama. Na post a, anyị ga-atụle echiche abụọ gbasara ihe na-adịghị mma na ihe m chere na ọ bụ ihe akaebe na-akpali akpali. Mgbe ahụ, anyị ga-ekwu maka ezigbo nzọụkwụ mbụ iji malite ịza ya na mgbe ahụ ihe m na-ahụ na ọ dị irè n'ọrụ m dị ka onye ndụmọdụ ahụike uche nwere ikikere na-eji ụkpụrụ isi mgbaka na-arụ ọrụ na-arụ ọrụ na ndị ahịa m. Ọtụtụ n'ime ha na-ata ahụhụ site na mgbaama mgbaama, na-enweghị amata dị ka nsogbu ọnọdụ ọnọdụ, n'oge dị iche iche.

Echiche netwọkụ nke ọrịa Alzheimer

Echiche a nwere ụfọdụ ezigbo ihe akaebe iji kwado ya ma jiri data sitere na MRI arụ ọrụ. Ihe ha na-achọpụta bụ na e nwere nsogbu n’otú akụkụ ụbụrụ dị iche iche si agwa ibe ha okwu nakwa na ọ na-eme nnọọ n’oge usoro ọrịa ahụ. N'ezie, ndị mmadụ nwere ikike ịmalite ọrịa Alzheimer (dịka ọmụmaatụ, APOE-ε4 ndị na-ebu) nwere ike ịmalite ịhụ njikọ nke dysfunctional na-eme tupu mgbaàmà ọ bụla. Ọ na-amalite ịmalite n'azụ Netwọk ọnọdụ ndabara (DMN) na ozugbo ọ na-amalite njem na netwọk nlebara anya azụ (DAN) Ndị nchọpụta na-amalite ịhụ ihe mgbaàmà na-apụta nke mmerụ ahụ dị nro (MCI). Akụkụ ụbụrụ a na-eme kpọmkwem ihe aha ya ga-atụ aro. Ọ na-enye gị ohere ịṅa ntị. Ọ bụrụ na ịnweghị ike ịṅa ntị, ịgaghị anabata ozi nke ọma ma ebe nchekwa episodic na-emebi.

ep·i·sod·ic mem·o·ry - noun (Oxford Languages ​​via Google) ụdị ncheta ogologo oge nke gụnyere icheta nke ọma ahụmahụ ndị gara aga yana ihe gbara ya gburugburu n'ihe gbasara oge, ebe, mmetụta mmetụta, wdg.
"Nsonaazụ ndị ahụ na-egosi na ndị sonyere na-eji ebe nchekwa episodic na-echeta okwu ndị egosipụtara n'ọnọdụ niile."

ebe nchekwa maara nke ahụmahụ gara aga.
"Hippocampus na-etinye aka nke ukwuu n'ichepụta ihe ncheta" 

Ka ndị na-eme nchọpụta na-ekiri mbelata na ọganihu njikọta ọrụ, ha nwere ike ịhụ na ọbụna buru amụma mbelata arụmọrụ na ọrụ nlebara anya nke gụnyere ịmụrụ anya, na-atụgharị uche n'ihe chọrọ nlebara anya na ijide nlebara anya. Enwekwara mbelata ọrụ njikọta n'ime netwọkụ nke ọma ma na-agụnye akụkụ ụbụrụ dị mkpa nke cingulate ihu na ventral anterior insular cortices, nke na-agụnyekwa akụkụ dị mkpa nke nkwurịta okwu na amygdala, ventral striatum, brainstem, thalamus na hypothalamus. Ndị dị iche iche ga-enwe nsogbu njikọta n'akụkụ dị iche iche nke ụbụrụ, yabụ ị nwere ike ịhụ nsogbu na ikike mmadụ iji nyochaa ọrụ nke ya ma ọ bụ ihe mgbagwoju anya ka ọrịa na-aga n'ihu.

Ezughị oke ike ụbụrụ

Ọ bụrụ na ị na-enwe mgbaàmà ọrịa neurodegenerative (ụbụrụ ụbụrụ, MCI, dementia), ị na-enwe nsogbu metabolism ume glucose na ụbụrụ gị. Kedu ihe nke ahụ pụtara? Ọ pụtara na enwere akụkụ ụbụrụ gị na-anata obere glucose ma na-emepụta obere ume. O yikarịrị ka ọ na-eme na mpaghara lobe medial gị nke gụnyere hippocampus, cortex entorhinal, na cortex cingulate nke azụ anyị tụlere nke ahụ bụ akụkụ nke DMN azụ. Nke a bụ nsogbu n'ihi na ebe ndị a bụ ebe ndị nchọpụta maara na ọ na-etinye aka mgbe ncheta episodic na-emebi. Mana mbelata mmanụ ọkụ a n'akụkụ ụbụrụ ndị a bụ ihe karịrị naanị ọrụ ebe nchekwa. Ọ dị mkpa ịghọta na ụbụrụ na-ewe ike dị ukwuu iji chekwaa neurons ma ozugbo enwere ụkọ ike ụbụrụ ụbụrụ gị enweghị ike ịrụ ọrụ ndị bụ isi iji hụ na ahụike na arụ ọrụ nke sel:

  • akpụkpọ anụ akpụkpọ anụ
  • okike na ọrụ nke batrị cell (mitochondria)
  • na-echekwa nri dị mkpa iji mepụta neurotransmitters na enzymes
  • inwe ezigbo mkpụkọ siri ike nke ime ihe nwere ike igosipụta n'etiti neurons

Enwere m ike ịga n'ihu na ụzọ niile naanị enweghị ike zuru oke na ụbụrụ na-emepụta cascade neurodegenerative nke ya na ụgbọ oloko gbapụrụ agbapụ nke mbibi ọgụgụ isi.

Ugbu a, ezuru nke a okwu banyere ihe na-eme adịghị mma. Ka anyị malite mkparịta ụka otu esi edozi ya.

Tinye ketones

Ketone na-enye mmanụ ọzọ maka akụkụ ụbụrụ nke agụụ na-agụ. Cheta mkparịta ụka anyị gbasara akụkụ ụfọdụ nke ụbụrụ na-enweghị ike iji glucose mee mmanụ ọkụ? Ketones na-agafe usoro ndị ahụ na-ezighi ezi ma na-edozi metabolism ike. Ketones bụ ụmụ irighiri ihe na-egosi, ma nwee ọtụtụ ọrụ ndị ọzọ magburu onwe ya karịa dị ka mmanụ ọzọ.  

Ntinye aka Ketogenic bụ ugbu a atụmatụ neurotherapeutic na-ekwe nkwa iji weghachi ọrụ ọgụgụ isi na MCI na AD

Roy, M., Edde, M., Fortier, M., Croteau, E., Castellano, CA, St-Pierre, V., … & Descoteaux, M. (2022). Ntinye aka ketogenic na-eme ka arụ ọrụ netwọk nlebara anya azụ azụ yana njikọta n'ụdị nhụsianya dị nro. Neurobiology nke ịka nká. https://doi.org/10.1016/j.neurobiolaging.2022.04.005

Uru kacha pụta ìhè ketone na-enye bụ mmanụ maka mpaghara agụụ na-agụ nke ụbụrụ. Ma ha na-eme ọtụtụ ihe. Ketones dị mkpa n'ụzọ ahazi maka nlekọta mkpụrụ ndụ ụbụrụ yana ọgwụgwọ. Dịka ọmụmaatụ, ha na-ewu ụlọ maka sheaths myelin nke na-echebe irighiri akwara site na ọkụ eletrik nke ike ime ihe ma na-achọ nrụzi mgbe niile. N'ime ọrụ ha dị ka ahụ na-egosi, ha na-agbanye ụzọ mgbochi mkpali, ọ bụ ezie na m ga-arụ ụka na ọ bụrụ na ịdabere na mgbakwunye ketone exogenous naanị na-enweghị ịgbanwe nri mkpali, uru ndị a ga-abụ nke ọma maka onye na-arụ ọrụ iji gwọọ ụbụrụ ha. Ketones na-ebelata nrụgide oxidative ma melite njikọta n'etiti akụkụ ụbụrụ, ọbụlagodi n'ime ebe ihe ọcha dị omimi na ụbụrụ. Ha na-edozi mmepụta nke Brain-Derived Neurotrophic Factor (BDNF) nke na-enye aka na njikọ ahụ dị mma na nrụzi neuronal, ihe a na-arụkwa ọrụ dị mkpa na ebe nchekwa na hippocampus.

Ketones na-emeziwanye iguzosi ike n'ezi ihe nke mgbochi ụbụrụ ọbara-ụbụrụ, nke nwere ọrụ dị mkpa iji chebe ụbụrụ site na nsị ma ọ bụ ihe ndị ọzọ ga-eme ka usoro mkpali na-eme ka ụbụrụ dịkwuo elu. Ha na-edozi mmepụta nke glutathione, nke bụ usoro antioxidant nke anụ ahụ nke e mere iji nyere aka ịlụso nrụgide oxidative ọgụ (ee, karịsịa na ụbụrụ).

Ketones na-enye aka n'ọtụtụ ọkwa ọ bụghị naanị na-anapụta ọrụ ọgụgụ isi kamakwa iji gwọọ ụbụrụ na nwayọ ma ọ bụ ikekwe kwụsị, usoro neurodegenerative.

Usoro ọgwụgwọ Ketogenic

Ka ị na-eme nyocha gị maka otu esi emeziwanye ọrụ ọgụgụ isi, ị ga-ezute ọmụmụ gbasara ketones na ụzọ dị iche iche enwere ike isi nye ketones. Enwere ketone dịpụrụ adịpụ nke mmadụ nwere ike ịṅụ ma ọ bụ tinye na nri n'ụdị mmanụ MCT, dịka ọmụmaatụ. Ma ọ bụ enwere ketone nke a na-eme site na mmadụ na-agbaji abụba erimeri ma ọ bụ abụba anụ ahụ ya n'ime ahụ ketone. Na e nwere N'ezie Nchikota nke abụọ. Ọtụtụ ọmụmụ na-ele anya na mmanụ MCT. Mmanụ MCT bụ mmanụ dị mma maka ụbụrụ, ana m akwado ya nke ukwuu. Ma ọ nwere ike ịkpata ọtụtụ nsogbu mgbari nri na ya mere a ga-eji nwayọọ nwayọọ na-arụ ọrụ ya na dose. Otú ọ dị, n'ihi na ọ nwere ihe ndọghachi azụ digestive dị iche iche (afọ ọsịsa) maka ọtụtụ ndị mmadụ, ọ nwere ike isi ike ma ọ bụ mgbe ụfọdụ ọ gaghị ekwe omume ịrụ ọrụ ruo n'ókè nke na-ebelata mgbaàmà.

Site n'ụzọ dị irè, ọ bụrụ na ị rịọ onye ọ bụla ka ọ were mmanụ MCT, ha ga-agwa gị ọbụna otu tablespoon (15mL) nwere ike ịkpata nsogbu. N'otu nnyocha m lere anya na ndị sonyere ga-amalite na 50mL (ihe dịka 3 TBSP) wee rụọ ọrụ ruo 250mL (ihe dịka 17 TBSP). A ghaghị ịrụ ọrụ ndị na-eso ya ruo nnukwu dose dị otú ahụ n'elu ọnwa 6, na ụdị ihe akaebe nke ọmụmụ (n'oge m na-ede blọgụ a) akọwapụtaghị ugboro ole ndị sonyere na-achọ ka ha were onwe ha. (Lee Roy, et al., 2022 na ntụaka).

Ihe kpatara na ị were ọtụtụ mmanụ MCT abụghị azịza ya

Ọnọdụ nguzogide insulin gị dịkwa mkpa na ọganihu ọrịa neurodegenerative. Ọ dị mma iji mmanụ MCT mụbaa mmanụ ụbụrụ gị nke ga-enyere aka inye ketones ime ihe niile na-agwọ ụbụrụ gị. Mana ilekwasị anya na naanị ịba ụba ketone adịghị ekwupụta na ụbụrụ na-agba na glucose abụghị ụbụrụ obi ụtọ. Ọ bụrụ na ị nwetala nguzogide insulin, ị ga-achọ ịgbanwe nri gị nke ukwuu iji meziwanye ma ọ bụ gbanwee ọnọdụ ọrịa a.

Kpọmkwem, ebe ndị mmadụ na-ebu ọnụ glucose na-ebu ọnụ egosighi mbelata ọgụgụ isi, ha nwere atrophy mpaghara na hippocampus na obere parietal cortex, yana mmụba amyloid na cortex precuneus.

Honea, RA, John, CS, Green, ZD, Kueck, PJ, Taylor, MK, Lepping, RJ, … & Morris, JK (2022). Mmekọrịta nke glucose na-ebu ọnụ na akara ngosi ọrịa Alzheimer ogologo oge. Alzheimer's & Dementia: Nchọgharị Ntụgharị na Ntugharị Ahụike8(1), e12239. https://doi.org/10.1002/trc2.12239

Ọzọkwa, ka ị na-eme agadi, o yikarịrị ka ị mepụtala insulin na-eguzogide na-abawanye, yana imeziwanye mmetụta insulin gị nwere ike inye aka gbochie ọrịa ịka nká. Ndị nwere oke insulin na-eguzogide ọgwụ nọ n'ihe ize ndụ dị ukwuu nke ọtụtụ usoro ọrịa, ma ọ bụ n'ụzọ kpatara ya ma ọ bụ na ọ dịkarịa ala n'ụzọ dị ukwuu na mkpakọrịta na nke a na-enyo enyo. Kedu ụfọdụ n'ime ọrịa ndị a chọpụtara na ha nwere mgbọrọgwụ na nguzogide insulin a na-agwọghị? Ma ọ bụ ma ọ dịghị ihe ọzọ, mkpakọrịta dị elu? Ha gụnyere ndị a:

  • Ọrịa obi - ọbara mgbali elu, Atherosclerosis, Cardiomyopathy, hyperlipidemia profaịlụ
  • Neurological - Ọrịa Alzheimer, Ọrịa Parkinson, Vascular Dementia, isi ọwụwa Migraine, Neuropathy.
  • Ọrịa cancer - ara, Prostate, na Colorectal
  • Musculoskeletal - Sarcopenia, Osteoporosis, Osteoarthritis
  • Digestive - Gout, Reflux Esophagitis (GERD), Nsogbu na-agafe stool (Gastroparesis)
  • Ọrịa imeju - hyperlipidemia (nke na-egosi nsogbu na imeju, ọ bụghị usoro obi), ọrịa imeju na-adịghị egbu egbu,
  • Gallbladder na Ọrịa Akụrụ - Nkume Gallstone, Akụrụ, Akụrụ Adịghị

Usoro ọrịa ndị a ga-ezuru ike gị na ịdịmma ndụ gị dị ka ihe mgbaàmà enweghị ọgwụgwọ na ọrịa Alzheimer ma ọ bụ mgbaka ọzọ ga-esi. Ma e wezụga eziokwu ahụ, usoro ọrịa ndị a na-adịghị ala ala na-emetụtakwa ụbụrụ gị na-apụtaghị ìhè.

Naanị inye ụbụrụ isi ihe ọzọ mmanụ ọkụ abụghị ihe enyemaka zuru oke maka nhụta nhụta dị nro ma ọ bụ ọrịa Alzheimer n'oge. Ọ bụghị ma ọ bụrụ na anyị na-eche banyere ahụ dum na ọdịnihu gị àgwà ndụ. Dịka ọmụmaatụ, ọ bụrụ na ị na-enye onwe gị ọtụtụ mmanụ MCT, ma nwee ahụ iru ala na ụbụrụ gị, mana agbanwela nri gị iji nyere aka gbanwee nkwụsị insulin (nke nri ketogenic na-eme), mgbe ahụ ka atherosclerosis na-aga n'ihu, ị ga-amalite inwe ọrịa obi.

Ka ọrịa obi gị na-aga n'ihu, ị ga-amalite inwe nsogbu na ikuku oxygen na nri na-ebunye n'ụbụrụ gị na akụkụ ahụ gị ndị ọzọ. Na nke ahụ bụ naanị otu n'ime ọtụtụ usoro na-emebi ọrịa obi nke nwere ike imetụta ahụ ike nke ụbụrụ. Usoro obi na-ada ada ga-emetụta ụbụrụ gị n'ezie. Achọghị m ịma ole mmanụ MCT ị na-ewere.

mmechi

M na-ahụ nsonaazụ ụlọ ọgwụ ka mma mgbe anyị mejuputa nri ketogenic maka ọgwụgwọ adịghị ike nke ọgụgụ isi, ma ọ dị ntakịrị karịa ụbụrụ ụbụrụ na-agba ọsọ nke ọtụtụ mmadụ na-enweta, nke a chọpụtara n'ụzọ nkịtị Mild Cognitive Impairment (MCI), ma ọ bụ ọbụna mmalite mgbaka. A na-eji mmanụ MCT na ihe mgbakwunye ketone ndị ọzọ na-ewulite n'elu ntọala ketogenic nke ụbụrụ ụbụrụ nke na-eme na mmachi carbohydrate ọgwụgwọ. Mmanụ MCT bụ nkwalite. Ọ bụghị ntinye aka na-azọpụta ụbụrụ gị. Mmanụ MCT n'onwe ya bụ enyemaka enyemaka maka usoro neurodegenerative. Na-enweghị mbelata nke carbohydrates na-agwọ hyperglycemia na insulin resistance, ị naghị ekwu nke ọma usoro neurodegenerative ga-aga n'ihu na-eme na ndabere. Ma ndị a na-eme ozugbo na ụbụrụ (nke m na-ekwe nkwa na ha bụ) ma ọ bụ site na usoro ọrịa na-adịghị ala ala nke abụọ, dị ka ndị anyị gụrụlarị banyere ya.

Anaghị m agwa gị mkpirisi nke mmanụ MCT n'ịgwọ usoro neurodegenerative iji mee ka ị nwee obi nkoropụ. Amaara m na enwere ike ịgbanwe nri gị iji belata, kwụsị ma ọ bụ ọbụna gbanwee usoro ọrịa gị siri ike, ma ị nwere ike ị gaghị ejide n'aka ihe nke ahụ ga-adị ka ya. Ị nwere ike ịhụ posts blọọgụ ndị a na-enyere aka.

M na-ede nke a n'ihi na ọ bụrụ na gị ma ọ bụ onye ị hụrụ n'anya na-ata ahụhụ site na mgbaàmà uche, achọghị m ka ị were mmanụ MCT, ghara ịhụ ọganihu, wee hapụ ikwere na ketones nwere ike inyere gị aka. Mmanụ MCT naanị abụghị otu ọkwa ntinye aka na nri ketogenic emebere nke ọma, ọ bụghịkwa otu ntinye aka ị ga-enweta ma ọ bụrụ na ị jikọtara ha abụọ. Enwere m ọtụtụ ndị ahịa na-enwe mmetụta ọ bụla na-enweghị ihe ọ bụla mgbe ha na-agbakwunye mmanụ MCT mana ha chere na ụbụrụ ha na-agwọ ma melite ọrụ site na iji nri ketogenic.

Ya mere, ọ bụrụ na mmanụ MCT anaghị ebelata mgbaàmà gị, biko egbula olileanya.

Inye ketones, ma site na nri ketogenic edoziri nke ọma ma ọ bụ na mmụba MCT bụ nzọụkwụ mbụ n'ịgbapụta ọrụ ọgụgụ isi. Nzọụkwụ nke abụọ nwere ike ịbụ nyocha nke nutrigenomic iji hụ na oriri micronutrient zuru oke, na nyocha ọzọ iji wepụ ihe ndị ọzọ na usoro ọrịa ahụ, a na-ejikarị nyocha ọgwụ na-arụ ọrụ. Mana nke mbụ, anyị ga-anapụta ike ụbụrụ.

Ketones na-eme nke ahụ.

Ma ihe ọ bụla i kpebiri, egbula oge. Oge bụ ihe kacha mkpa n'ịgwọ ọrịa neurodegenerative.

Ọ bụrụ na ị bụ nwanyị na-arịa ọrịa mgbaama nke uche, n'ụdị ụbụrụ ụbụrụ, ihe isi ike ilekwasị anya ma ọ bụ icheta ihe, ma ọ bụ ịṅa ntị. biko debanye aha maka nyocha mmemme m. M na-eke mmemme iji nyere aka weta usoro ọgwụgwọ na mgbanwe ndị a nye ụmụ nwanyị n'ụzọ na-alụ di na nwunye na-edozi ahụ na-arụ ọrụ mgbaka na nkwado otu na nkuzi iji hụ na ịga nke ọma.

Ị nwere ike ịmụtakwu banyere ya ebe a:

Ọ bụrụ n’ịchọrọ ịdebanye aha maka ndepụta nzipu ozi ka ị mụta maka mmemme, nkuzi na ohere mmụta na-abịa, ị nwere ike ime ya ebe a:

N'ihi na ị nwere ikike ịmara ụzọ niile ị ga-esi nweta mma.


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